System for determination of an analyte in a bodily fluid sample that includes an electroluminescent component

• US 7,740,801 B2
• Filed: 10/31/2006
• Issued: 06/22/2010
• Est. Priority Date: 10/31/2006
• Status: Expired due to Fees

• Current Assignee: Cilag Gmbh International (Johnson & Johnson)
• Original Assignee: LifeScan Scotland Limited (Johnson & Johnson)
• Inventors: Mills, Leanne, Saini, Selwayan, Blythe, Stephen Patrick, Cardosi, Marco Fabio
• Primary Examiner(s): Griffin; Walter D
• Assistant Examiner(s): Ramdhanie; Bobby
• Application Number:
  US11/591,138
• Publication Number:
  US 20080101985A1
• Time in Patent Office: 1,330 Days
• Field of Search: 422/52
• US Class Current: 422/52
• CPC Class Codes: G01N 2021/6439 with indicators, stains, dyes, tags, labels, marks
• CPC Class Codes: G01N 21/69 specially adapted for fluids , e.g. molten metal
• CPC Class Codes: G01N 21/76 Chemiluminescence; Bioluminescence

Abstract

A system for the determination of an analyte in a bodily fluid sample includes an analytical test strip and an analytical meter. The analytical test strip has a substrate layer, an electroluminescent component (either an electroluminescent module and/or an electroluminescent lamp) disposed on the substrate layer, and a sample chamber configured for receiving a bodily fluid sample disposed above the substrate layer. Moreover, the analytical meter is configured for insertion of the analytical test strip therein and subsequent determination of the analyte.

Claims

1. A system for the determination of an analyte in a bodily fluid sample, the system comprising:

an analytical test strip that includes;

a substrate layer;

an electroluminescent component disposed on the substrate layer, the electroluminescent component including;

a rear electrode layer;

an electrically-insulating layer disposed over the rear electrode layer;

a phosphor layer disposed over the electrically insulating layer;

a front electrode layer, at least a portion of which is translucent, disposed over the phosphor layer; and

an encapsulant layer; and

a sample chamber configured for receiving a bodily fluid sample disposed above the substrate layer; and

an analytical meter configured for insertion of the analytical test strip therein and subsequent determination of an analyte in the bodily fluid sample.

2. The system of claim 1 wherein the electroluminescent component is an electroluminescent module and wherein the analytical test strip also includes a fluorophore-containing photometric enzymatic reagent disposed within the sample chamber, and a photodetector disposed above the substrate layer, wherein the electroluminescent module is in optical communication with the sample chamber, and wherein the electroluminescent module is configured to emit light that facilitates a fluorescent chemical reaction sequence between the fluorophore-containing photometric enzymatic reagent and the analyte.

3. The system of claim 2 wherein the photodetector includes a photo-resistor electrode formed from one of cadmium sulphide and cadmium selenide.

4. The system of claim 2 wherein the fluorophore-containing photometric enzymatic reagent includes glucose oxidase, horseradish peroxidase, Amplex Red reagent and any combinations thereof.

5. The system of claim 2 wherein the fluorescent chemical reaction sequence produces resorufin such that fluorescence of the resorufin emits photons proportional to the concentration of analyte in the bodily fluid sample.

6. The system of claim 2 wherein the electroluminescent module is an electroluminescent lamp, and

wherein the electroluminescent lamp is configured to emit light, the light being visible to a user of the analytical test strip and providing the user with spatial awareness of the analytical test strip.

7. The system of claim 1 wherein the analytical test strip and analytical meter are configured for the determination of glucose in a whole blood sample.

8. The system of claim 1 wherein the electroluminescent component further includes a wavelength modulation layer configured to shift the wavelength of light emitted by the phosphor layer, the wavelength modulation layer embedded or dispersed within the encapsulant layer.

9. The system of claim 8 wherein the wavelength modulation layer includes fluorescein.

10. The system of claim 8 wherein the wavelength modulation layer includes rhodamine.

11. The system of claim 8 wherein the wavelength modulation layer shifts the wavelength of light emitted by the phosphor layer via a Stoke'"'"'s shift.