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Epitope-captured antibody display

  • US 7,741,062 B2
  • Filed: 04/07/2009
  • Issued: 06/22/2010
  • Est. Priority Date: 04/17/2001
  • Status: Expired due to Fees
First Claim
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1. An array of polypeptides, comprising(a) a support;

  • and(b) a plurality of replicable genetic package/antibody reagents (package/antibody reagents) immobilized at different locations on the support;

    wherein;

    each of the replicable genetic package/antibody reagents comprises;

    (i) a replicable genetic package having a heterologous nucleic acid segment that encodes a polypeptide displayed on the replicable genetic package; and

    (ii) a captured antibody bound to the displayed polypeptide, wherein the captured antibody has a plurality of binding sites with at least one first binding site having specific binding affinity for the displayed polypeptide and at least one second binding site which is unbound; and

    the replicable genetic package of each package/antibody reagent is immobilized on the support.

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