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Cross-linking of low and high molecular weight polysaccharides preparation of injectable monophase hydrogels and polysaccharides and hydrogels thus obtained

  • US 7,741,476 B2
  • Filed: 04/08/2004
  • Issued: 06/22/2010
  • Est. Priority Date: 04/10/2003
  • Status: Active Grant
First Claim
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1. Process of preparing a cross-linked polymer comprising 1) forming a mixture of a first hyaluronic acid salt product having a first molecular weight and a second hyaluronic acid salt product having a second molecular weight greater than the first molecular weight, wherein the first hyaluronic acid salt product and the second hyaluronic acid salt product are two separate pre-existing products prior to the forming step;

  • and

         2) cross-linking the mixture of step

         1) in an aqueous solvent in the presence of an effective and non-excessive amount of at least one cross-linking agent, such that the degree of cross-linking, defined by the ratio;

    100×

    (total number of reactive groups in said cross-linking agent/total number of disaccharide units in the first hyaluronic acid salt and second hyaluronic acid salt), is theoretically between 0.5 and 70%.

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