Short duration pre-pulsing to reduce stimulation-evoked side-effects
First Claim
1. A method of providing therapy to a patient, comprising placing at least one electrode in contact with tissue of a patient;
- conveying a sub-threshold, hyperpolarizing, conditioning pre-pulse from the at least one electrode that renders a first region of the tissue less excitable to stimulation; and
conveying a depolarizing stimulation pulse from the at least one electrode to stimulate a second different region of the tissue, wherein the duration of the conditioning pre-pulse is equal to or shorter than the stimulation pulse.
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Accused Products
Abstract
A method and neurostimulation system of providing therapy to a patient is provided. At least one electrode is placed in contact with tissue of a patient. A sub-threshold, hyperpolarizing, conditioning pre-pulse (e.g., an anodic pulse) is conveyed from the electrode(s) to render a first region of the tissue (e.g., dorsal root fibers) less excitable to stimulation, and a depolarizing stimulation pulse (e.g., a cathodic pulse) is conveyed from the electrode(s) to stimulate a second different region of the tissue (e.g., dorsal column fibers). The conditioning pre-pulse has a relatively short duration (e.g., less than 200 μs).
208 Citations
25 Claims
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1. A method of providing therapy to a patient, comprising placing at least one electrode in contact with tissue of a patient;
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conveying a sub-threshold, hyperpolarizing, conditioning pre-pulse from the at least one electrode that renders a first region of the tissue less excitable to stimulation; and conveying a depolarizing stimulation pulse from the at least one electrode to stimulate a second different region of the tissue, wherein the duration of the conditioning pre-pulse is equal to or shorter than the stimulation pulse. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A method of providing therapy to a patient, comprising:
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placing at least one electrode in contact with spinal nerve tissue of a patient; conveying a sub-threshold, hyperpolarizing, conditioning pre-pulse from the at least one electrode to the tissue, wherein the conditioning pre-pulse has a duration less than 200 μ
s; andconveying a depolarizing stimulation pulse from the at least one electrode to the tissue, wherein the duration of the conditioning pre-pulse is equal to or shorter than the stimulation pulse. - View Dependent Claims (16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
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Specification