Gastro-electric stimulation for increasing the acidity of gastric secretions or increasing the amounts thereof
First Claim
1. A method for at least one of increasing the acidity of gastric acid secretion in a stomach of a human patient and increasing an amount of the gastric acid secretion produced in the human patient'"'"'s stomach, comprising:
- providing a hermetically sealed implantable electrical pulse generator configured to provide at least one electrical stimulation pulse regime effective to at least one of decrease the pH of gastric acid secretion and increase the amount of the gastric acid secretion produced in the human patient'"'"'s stomach;
providing at least a first implantable medical electrical lead configured for implantation adjacent, around or in a selected electrode stimulation site, the electrode stimulation site comprising at least one of a stomach, a plexus on an anterior superior and/or anterior inferior pancreaticoduodenal arteries, a plexus on a inferior pancreaticoduodenal artery, a plexus on a jejunal artery, a superior mesenteric artery and plexus, a plexus on a gastroepiploic arteries, a celiac ganglia and plexus, a splenic artery and plexus, a left lesser thoracic splanchic nerve, a left greater thoracic splanchic nerve, a principal anterior gastric branch of an anterior vagal trunk, a left gastric artery and plexus, a celiac branch of the anterior vagal trunk, a hepatic branch of the anterior vagal trunk, a right and/or left inferior phrenic arteries and plexus, an anterior posterior layers of a lesser omenium, a branch from a hepatic plexus to a cardia via the lesser omenium, the right greater thoracic splanchic nerve, a vagal branch from the hepatic plexus to a pylorus, and a right gastric artery and plexus, and the first lead comprising proximal and distal ends and at least one electrode;
implanting the first lead in tissue of the human patient adjacent, around or in the selected electrode stimulation site;
operably connecting the proximal end of the at least first lead to the implantable pulse generator;
implanting the implantable pulse generator within the human patient; and
delivering electrical stimulation pulses from the implantable pulse generator to the selected electrode stimulation site through the at least first lead and electrode, wherein the human patient suffers from at least one of gastric hypoacidity and inadequate gastric acid production and the pulses are provided in accordance with the electrical stimulation pulse regime to at least one of increase the acidity of the gastric acid secretion and increase the amount of the gastric acid secretion produced by the human patient'"'"'s stomach.
1 Assignment
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Accused Products
Abstract
A gastro-electric stimulation system includes an INS for producing an electrical stimulation signal, at least one medical electrical lead, and at least two electrical contacts. The medical electrical lead has a proximal end and a distal end, the proximal end being connected to the INS and the distal end being adapted for placement in or near a patient'"'"'s stomach or appropriate nerve or nerve portion. The electrodes are disposed near the distal end of the medical electrical lead, and the electrodes are electrically connected through the medical electrical lead to the INS to receive the electrical stimulation signal and convey such signal to the selected electrode implant position. The electrical stimulation signal is provided in an amount and manner adapted to decrease the pH of the gastric acid in the patient'"'"'s stomach and/or to increase the amount of gastric acid produced thereby.
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Citations
50 Claims
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1. A method for at least one of increasing the acidity of gastric acid secretion in a stomach of a human patient and increasing an amount of the gastric acid secretion produced in the human patient'"'"'s stomach, comprising:
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providing a hermetically sealed implantable electrical pulse generator configured to provide at least one electrical stimulation pulse regime effective to at least one of decrease the pH of gastric acid secretion and increase the amount of the gastric acid secretion produced in the human patient'"'"'s stomach; providing at least a first implantable medical electrical lead configured for implantation adjacent, around or in a selected electrode stimulation site, the electrode stimulation site comprising at least one of a stomach, a plexus on an anterior superior and/or anterior inferior pancreaticoduodenal arteries, a plexus on a inferior pancreaticoduodenal artery, a plexus on a jejunal artery, a superior mesenteric artery and plexus, a plexus on a gastroepiploic arteries, a celiac ganglia and plexus, a splenic artery and plexus, a left lesser thoracic splanchic nerve, a left greater thoracic splanchic nerve, a principal anterior gastric branch of an anterior vagal trunk, a left gastric artery and plexus, a celiac branch of the anterior vagal trunk, a hepatic branch of the anterior vagal trunk, a right and/or left inferior phrenic arteries and plexus, an anterior posterior layers of a lesser omenium, a branch from a hepatic plexus to a cardia via the lesser omenium, the right greater thoracic splanchic nerve, a vagal branch from the hepatic plexus to a pylorus, and a right gastric artery and plexus, and the first lead comprising proximal and distal ends and at least one electrode; implanting the first lead in tissue of the human patient adjacent, around or in the selected electrode stimulation site; operably connecting the proximal end of the at least first lead to the implantable pulse generator; implanting the implantable pulse generator within the human patient; and delivering electrical stimulation pulses from the implantable pulse generator to the selected electrode stimulation site through the at least first lead and electrode, wherein the human patient suffers from at least one of gastric hypoacidity and inadequate gastric acid production and the pulses are provided in accordance with the electrical stimulation pulse regime to at least one of increase the acidity of the gastric acid secretion and increase the amount of the gastric acid secretion produced by the human patient'"'"'s stomach. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26)
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27. A method comprising:
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generating electrical stimulation having one or more parameters selected to produce at least one of increased acidity of gastric acid secretion in a stomach of a human patient and an increased amount of the gastric acid secretion in the stomach of the human patient; and delivering the electrical stimulation to a portion of the human patient via an implantable electrical lead, the portion of the human patient comprising at least one of the stomach, a plexus on an anterior superior and/or anterior inferior pancreaticoduodenal arteries, a plexus on a inferior pancreaticoduodenal artery, a plexus on a jejunal artery, a superior mesenteric artery and plexus, a plexus on a gastroepiploic arteries, a celiac ganglia and plexus, a splenic artery and plexus, a left lesser thoracic splanchic nerve, a left greater thoracic splanchic nerve, a principal anterior gastric branch of an anterior vagal trunk, a left gastric artery and plexus, a celiac branch of the anterior vagal trunk, a hepatic branch of the anterior vagal trunk, a right and/or left inferior phrenic arteries and plexus, an anterior posterior layers of a lesser omenium, a branch from a hepatic plexus to a cardia via the lesser omenium, the right greater thoracic splanchic nerve, a vagal branch from the hepatic plexus to a pylorus, and a right gastric artery and plexus vagal branch from the hepatic plexus to a pylorus, and a right gastric artery and plexus, wherein the human patient suffers from at least one of gastric hypoacidity and inadequate gastric acid production. - View Dependent Claims (28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48)
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49. A method comprising:
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generating, via an electrical stimulator implanted in a human patient, electrical stimulation selected to produce increased acidity of gastric acid secretion in a stomach of the human patient and an increased amount of the gastric acid secretion in the stomach of the human patient; delivering the electrical stimulation from the implanted electrical stimulator to a portion of the human patient via one or more implantable electrical leads, the portion of the human patient comprising at least one of a stomach, a plexus on an anterior superior and/or anterior inferior pancreaticoduodenal arteries, a plexus on a inferior pancreaticoduodenal artery, a plexus on a jejunal artery, a superior mesenteric artery and plexus, a plexus on a gastroepiploic arteries, a celiac ganglia and plexus, a splenic artery and plexus, a left lesser thoracic splanchic nerve, a left greater thoracic splanchic nerve, a principal anterior gastric branch of an anterior vagal trunk, a left gastric artery and plexus, a celiac branch of the anterior vagal trunk, a hepatic branch of the anterior vagal trunk, a right and/or left inferior phrenic arteries and plexus, an anterior posterior layers of a lesser omenium, a branch from a hepatic plexus to a cardia via the lesser omenium, the right greater thoracic splanchic nerve, a vagal branch from the hepatic plexus to a pylorus, and a right gastric artery and plexus; and controlling the electrical stimulation delivered by the implanted electrical stimulator based at least in part on a sensed physical condition of the human patient, wherein the human patient suffers from at least one of gastric hypoacidity and inadequate gastric acid production.
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50. A method comprising:
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generating, via an electrical stimulator implanted in a human patient, electrical stimulation selected to produce increased acidity of gastric acid secretion in a stomach of the human patient and an increased amount of the gastric acid secretion in the stomach of the human patient; and delivering the electrical stimulation from the implanted electrical stimulator to a portion of the human patient via one or more implantable electrical leads, the portion of the human patient comprising at least one of the stomach, a plexus on an anterior superior and/or anterior inferior pancreaticoduodenal arteries, a plexus on a inferior pancreaticoduodenal artery, a plexus on a jejunal artery, a superior mesenteric artery and plexus, a plexus on a gastroepiploic arteries, a celiac ganglia and plexus, a splenic artery and plexus, a left lesser thoracic splanchic nerve, a left greater thoracic splanchic nerve, a left gastric artery and plexus, a right and/or left inferior phrenic arteries and plexus, an anterior posterior layers of a lesser omenium, a branch from a hepatic plexus to a cardia via the lesser omenium, the right greater thoracic splanchic nerve, and a right gastric artery and plexus, wherein the human patient suffers from at least one of gastric hypoacidity and inadequate gastric acid production.
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Specification