Hyper-fractionation of transmission history for medical diagnostic software
First Claim
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1. A method of assisting in the diagnosis of a patient in need thereof, said method comprising the steps of:
- (a) providing, in a physical computing device, a set of candidate diseases and associated initial parameters representing estimated probabilities of said candidate diseases;
(b) receiving, in said computing device, a patient transmission history for said patient being diagnosed, said patient transmission history comprising information about the presence or absence of disease in one or more family members or others nearby;
(c) fractionating said patient transmission history into a plurality of forms of transmission, using said computing device, wherein said fractionating comprises determining whether there is evidence for each of said plurality of forms of transmission being present or absent in said patient transmission history, and wherein at least one of said plurality of forms of transmission is a genetic form of transmission;
(d) using said computing device to iteratively modify said initial parameters representing estimated probabilities of said candidate diseases, using the information obtained from said fractionating of said patient transmission history into each of said plurality of forms of transmission, to obtain modified parameters representing modified estimated probabilities of said candidate diseases; and
(e) outputting a list capable of being displayed, said list comprising one or more of said candidate diseases having highest said modified estimated probabilities.
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Abstract
The difficulties in incorporating transmission history into medical diagnostic software are non-obvious. These are addressed here with systems and methods for hyper-fractionation of transmission history in a way that allows the full power of this information to be used in medical diagnostic software.
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Citations
37 Claims
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1. A method of assisting in the diagnosis of a patient in need thereof, said method comprising the steps of:
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(a) providing, in a physical computing device, a set of candidate diseases and associated initial parameters representing estimated probabilities of said candidate diseases; (b) receiving, in said computing device, a patient transmission history for said patient being diagnosed, said patient transmission history comprising information about the presence or absence of disease in one or more family members or others nearby; (c) fractionating said patient transmission history into a plurality of forms of transmission, using said computing device, wherein said fractionating comprises determining whether there is evidence for each of said plurality of forms of transmission being present or absent in said patient transmission history, and wherein at least one of said plurality of forms of transmission is a genetic form of transmission; (d) using said computing device to iteratively modify said initial parameters representing estimated probabilities of said candidate diseases, using the information obtained from said fractionating of said patient transmission history into each of said plurality of forms of transmission, to obtain modified parameters representing modified estimated probabilities of said candidate diseases; and (e) outputting a list capable of being displayed, said list comprising one or more of said candidate diseases having highest said modified estimated probabilities. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34)
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35. A computer readable medium having stored thereon instructions for directing a physical computing device to implement a method of assisting in the diagnosis of a patient in need thereof, the instructions comprising the steps of:
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(a) providing, in said computing device, a set of candidate diseases and associated initial parameters representing estimated probabilities of said candidate diseases; (b) receiving, in said computing device, a patient transmission history for said patient being diagnosed, said patient transmission history comprising information about the presence or absence of disease in one or more family members or others nearby; (c) fractionating said patient transmission history into a plurality of forms of transmission, using said computing device, wherein said fractionating comprises determining whether there is evidence for each of said plurality of forms of transmission being present or absent in said patient transmission history, and wherein at least one of said plurality of forms of transmission is a genetic form of transmission; (d) using said computing device to iteratively modify said initial parameters representing estimated probabilities of said candidate diseases, using the information obtained from said fractionating of said patient transmission history into each of said plurality of forms of transmission, to obtain modified parameters representing modified estimated probabilities of said candidate diseases; and (e) outputting a list capable of being displayed, said list comprising one or more of said candidate diseases having highest said modified estimated probabilities. - View Dependent Claims (36)
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37. A physical computing device for assisting in the diagnosis of a patient in need thereof, said computing device comprising:
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(a) a set of candidate diseases and associated initial parameters representing estimated probabilities of said candidate diseases; (b) means for receiving a patient transmission history for said patient being diagnosed, said patient transmission history comprising information about the presence or absence of disease in one or more family members or others nearby; (c) means for fractionating said patient transmission history into a plurality of forms of transmission, wherein said fractionating comprises determining whether there is evidence for each of said plurality of forms of transmission being present or absent in said patient transmission history, and wherein at least one of said plurality of forms of transmission is a genetic form of transmission; (d) means for iteratively modifying said initial parameters representing estimated probabilities of said candidate diseases, using the information obtained from said fractionating of said patient transmission history into each of said plurality of forms of transmission, to obtain modified parameters representing modified estimated probabilities of said candidate diseases; and (e) means for outputting a list capable of being displayed, said list comprising one or more of said candidate diseases having highest said modified estimated probabilities.
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Specification