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Devices and methods for interstitial injection of biologic agents into tissue

  • US 7,744,562 B2
  • Filed: 10/10/2006
  • Issued: 06/29/2010
  • Est. Priority Date: 01/14/2003
  • Status: Active Grant
First Claim
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1. A device for injecting a medical agent into tissue, the device comprising:

  • an elongate shaft comprising a length, a longitudinal axis, a proximal region and a distal region, wherein the distal region comprises a distal region longitudinal axis;

    a plurality of hollow needles having a sharp distal end, at least one discharge port, a length, and a needle axis along the needle length, wherein the needles are operably coupled to the elongate shaft distal region such that needle axes are substantially perpendicular to the elongate shaft distal region;

    a needle driver coupled to the elongate shaft configured to drive the needles substantially perpendicular to the distal region longitudinal axis and into the tissue; and

    a discharger configured to discharge the agent from the needle discharge ports, wherein the needle driver comprises a first body having the needles fixedly attached thereto and a second body having the needles slidably disposed therethrough, wherein the first body comprises a first side and a second side and wherein the second body comprises a first side and a second side, wherein the first sides are opposite relative to the second sides, and wherein each of the first sides and each of the second sides comprise a distal arm linkage and a proximal arm linkage, wherein the distal and proximal arm linkages comprise a first linkage arm pivotally coupled to the first body and a second linkage arm pivotally coupled to both the second body and to the first linkage arm about a linkage joint, such that urging the distal linkage joints and proximal linkage joints farther apart urges the first and second bodies closer together and urging the distal and proximal linkage joints closer together urges the first and second bodies farther apart, wherein the proximal linkage joints are secured to the elongate shaft, the device further comprising a first elongate member slidably coupled to the elongate shaft and having a first elongate member distal region secured to the distal linkage joint, such that distally sliding the first elongate member relative to the elongate shaft urges the distal and proximal linkage joints further apart and the needles along their needle axes out of the second body, and such that proximally retracting the first elongate member relative to the elongate shaft urges the distal and proximal linkage joints closer together and urges the needles into the second body.

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