Laminated drug-polymer coated stent with dipped and cured layers
First Claim
1. A drug-polymer coated stent, comprising:
- a stent framework;
a laminated drug-polymer coating disposed on the stent framework, the laminated drug-polymer coating including a plurality of thin drug-polymer layers, wherein the thin drug-polymer layers include a first therapeutic agent and a cured first polymer, andat least one thin barrier layer positioned between a first thin drug-polymer layer and a second thin drug-polymer layer, wherein the at least one thin barrier layer includes a cured second polymer, wherein the cured second polymer excludes drug interaction between the first thin drug-polymer layer and the second thin drug-polymer layer adjacent the at least one barrier layer.
1 Assignment
0 Petitions
Accused Products
Abstract
The present invention provides a method of applying a drug-polymer coating on a stent. A stent framework is dipped into a first polymeric solution including a first polymer, a first therapeutic agent, and a first solvent. The polymeric solution is dried and the first polymer is cured to form a thin drug-polymer layer on the stent framework. The steps of dipping the stent framework into the first polymeric solution, drying the first polymeric solution, and curing the first polymer are repeated until a target drug-polymer coating thickness is disposed on the stent framework. A drug-polymer coated stent including a stent framework and a laminated drug-polymer coated stent, a system for treating a vascular condition, and a method of treating a vascular condition are also disclosed.
-
Citations
23 Claims
-
1. A drug-polymer coated stent, comprising:
-
a stent framework; a laminated drug-polymer coating disposed on the stent framework, the laminated drug-polymer coating including a plurality of thin drug-polymer layers, wherein the thin drug-polymer layers include a first therapeutic agent and a cured first polymer, and at least one thin barrier layer positioned between a first thin drug-polymer layer and a second thin drug-polymer layer, wherein the at least one thin barrier layer includes a cured second polymer, wherein the cured second polymer excludes drug interaction between the first thin drug-polymer layer and the second thin drug-polymer layer adjacent the at least one barrier layer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
-
-
10. A system for treating a vascular condition, comprising:
-
a catheter; and a coated stent coupled to the catheter, the coated stent including a stent framework and a laminated drug-polymer coating disposed on the stent framework, the laminated drug-polymer coating including a plurality of thin drug-polymer layers and at least one thin barrier layer positioned between a first thin drug-polymer layer and a second thin drug-polymer layer , wherein the thin drug-polymer layers include a first therapeutic agent and a cured first polymer and wherein the at least one thin barrier layer includes a cured second polymer, wherein the cured second polymer excludes drug interaction between the first thin drug-polymer layer and the second thin drug-polymer layer adjacent the at least one barrier layer. - View Dependent Claims (11, 12, 13, 14, 15, 16, 17, 18, 19)
-
-
20. A method of treating a vascular condition, comprising:
inserting a drug-polymer coated stent within a vessel of a body, the drug-polymer coated stent including a laminated drug-polymer coating having a plurality of thin drug-polymer layers and at least one thin barrier layer positioned between a first thin drug-polymer layer and a second thin drug-polymer layer one, wherein the thin drug-polymer layers include a first therapeutic agent and a cured first polymer and wherein the at least one thin barrier layer includes a cured second polymer, wherein the cured second polymer excludes drug interaction between the first thin drug-polymer layer and the second thin drug-polymer layer adjacent the at least one barrier layer; and eluting at least one therapeutic agent from the laminated drug-polymer coating into the body, wherein the first polymer is cured with one of thermal activation, electrical activation, or ionizing irradiation. - View Dependent Claims (21, 22, 23)
Specification