Soluble ErbB3 and treatment of cancer
First Claim
1. A method for regulating heregulin activity, said method comprising administering an effective amount of an sErbB3 agent to a subject in need thereof, wherein the sErbB3 agent is a p85-sErbB3 or p45-sErbB3 polypeptide, and wherein the effective amount downregulates heregulin activity.
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Accused Products
Abstract
Regulation of sErbB3 isoforms in methods of regulating heregulin activity or ErbB receptor activities is disclosed. Cancer therapeutics and methods of therapeutically treating cancer comprising sErbB3 are also disclosed. Detection of sErbB3 in biological samples for risk assessment and prevention, screening, diagnosis, prognosis, theragnosis, evaluation of responsiveness to treatment, and/or monitoring of disease progression, recurrence, or metastasis of a cancer is disclosed as well. In examples, sErbB3 nucleic acid sequences, polypeptides, molecular probes, and antibodies are useful agents for regulation, expression, detection, and cancer therapeutics related to sErbB3.
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Citations
2 Claims
- 1. A method for regulating heregulin activity, said method comprising administering an effective amount of an sErbB3 agent to a subject in need thereof, wherein the sErbB3 agent is a p85-sErbB3 or p45-sErbB3 polypeptide, and wherein the effective amount downregulates heregulin activity.
Specification