Polymer compositions with bioactive agent, medical articles, and methods
First Claim
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1. A polymer composition comprising:
- a continuous hydrophobic phase comprising a mixture comprising;
a hydrophobic liquid comprising mineral oil; and
a hydrophobic thermoplastic elastomeric polymer;
absorbent hydrophilic microparticles dispersed within the hydrophobic liquid, wherein the hydrophilic microparticles comprise a crosslinked carboxylic acid-containing organic polymer; and
a bioactive agent having a particle size less than one micron dispersed in the hydrophilic microparticles, wherein the bioactive agent is selected from the group consisting of a metal oxide of silver, a metal oxide of copper, a metal oxide of zinc, and combinations thereof;
wherein the polymer composition is nonadherent and contains less than 1 wt % water based on the total weight of the composition.
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Abstract
A polymer composition that includes a hydrophilic polymer, an optional secondary organic polymer, and a bioactive agent distributed therein, wherein the bioactive agent is selected from the group consisting of a silver compound, a copper compound, a zinc compound, and combinations thereof.
159 Citations
23 Claims
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1. A polymer composition comprising:
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a continuous hydrophobic phase comprising a mixture comprising; a hydrophobic liquid comprising mineral oil; and a hydrophobic thermoplastic elastomeric polymer; absorbent hydrophilic microparticles dispersed within the hydrophobic liquid, wherein the hydrophilic microparticles comprise a crosslinked carboxylic acid-containing organic polymer; and a bioactive agent having a particle size less than one micron dispersed in the hydrophilic microparticles, wherein the bioactive agent is selected from the group consisting of a metal oxide of silver, a metal oxide of copper, a metal oxide of zinc, and combinations thereof; wherein the polymer composition is nonadherent and contains less than 1 wt % water based on the total weight of the composition. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A polymer composition comprising:
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a continuous hydrophobic phase comprising a mixture comprising; mineral oil; and a hydrophobic thermoplastic elastomeric polymer selected from the group consisting of styrene-isoprene-styrene (SIS), styrene-butadiene-styrene (SBS), styrene-ethylene-propylene-styrene (SEPS), styrene-ethylene-butylene-styrene (SEBS), and combinations thereof; absorbent hydrophilic microparticles dispersed within the mineral oil, wherein the hydrophilic microparticles comprise a crosslinked carboxylic acid-containing organic polymer; and a bioactive agent having a particle size less than one micron dispersed in the hydrophilic microparticles, wherein the bioactive agent is selected from the group consisting of a metal oxide of silver, a metal oxide of copper, a metal oxide of zinc, and combinations thereof; wherein the polymer composition is nonadherent and contains less than 1 wt % water based on the total weight of the composition. - View Dependent Claims (19, 20, 21)
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22. A polymer composition comprising:
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a continuous hydrophobic phase comprising a mixture comprising; mineral oil; and a hydrophobic thermoplastic elastomeric polymer selected from the group consisting of styrene-isoprene-styrene (SIS), styrene-butadiene-styrene (SBS), styrene-ethylene-propylene-styrene (SEPS), styrene-ethylene-butylene-styrene (SEBS), and combinations thereof; absorbent hydrophilic microparticles dispersed within the mineral oil, wherein the hydrophilic microparticles comprise a crosslinked a copolymer of sodium acrylate and acrylic acid; and silver oxide having a particle size less than one micron dispersed in the hydrophilic microparticles; wherein the polymer composition is nonadherent and contains less than 1 wt % water based on the total weight of the composition. - View Dependent Claims (23)
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Specification