Method for preparing peritoneal dialysate

• US 7,745,613 B2
• Filed: 09/22/2006
• Issued: 06/29/2010
• Est. Priority Date: 08/24/1998
• Status: Expired due to Term

• Current Assignee: Kiyoshi Kurokawa, Tokai University Educational System, Toshio Miyata
• Original Assignee: Kiyoshi Kurokawa, Tokai University Educational System, Toshio Miyata
• Inventors: Miyata, Toshio
• Primary Examiner(s): Lewis; Patrick T
• Application Number:
  US11/534,375
• Publication Number:
  US 20070020341A1
• Time in Patent Office: 1,376 Days
• Field of Search: None
• US Class Current: 536/26.4
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/155 Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
• CPC Class Codes: A61K 31/203 Retinoic acids ; Salts thereof
• CPC Class Codes: A61K 31/4965 Non-condensed pyrazines
• CPC Class Codes: A61K 33/00 Medicinal preparations containing inorganic active ingredients
• CPC Class Codes: A61M 1/287 Dialysates therefor
• CPC Class Codes: A61P 13/12 of the kidneys
• CPC Class Codes: A61P 43/00 Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
• CPC Class Codes: A61P 7/08 Plasma substitutes; Perfusion solutions; Dialytics or haemodialytics; Drugs for electrolytic or acid-base disorders, e.g. hypovolemic shock artificial tears A61P27/04

Abstract

Carbonyl compounds generated and accumulated in the peritoneal dialysate can be inactivated or eliminated by a carbonyl compound-trapping agent such as aminoguanidine. Carbonyl compounds generated during sterilization and storage of the peritoneal dialysate can be eliminated by pre-contacting with the trapping agent. Further, it is possible to eliminate carbonyl compounds transferred from the blood to the peritoneal cavity of the patient during peritoneal dialysis treatment, by adding the trapping agent to the peritoneal dialysate or by circulating the fluid through a carbonyl compound-trapping cartridge. Intraperitoneal protein modification by carbonyl compounds is inhibited by the present invention, thereby sufficiently reducing peritoneal disorders associated with peritoneal dialysis treatment.

Claims

1. An agent for improving intraperitoneal carbonyl-stress state during peritoneal dialysis, comprising pyridoxines or salts thereof as an active ingredient wherein the pyridoxines or salts thereof are immobilized on an insoluble carrier.

2. The agent of claim 1, wherein the pyridoxines is pyridoxamine.

3. A cartridge, comprising:

pyridoxines or salts thereof immobilized on the wall.

7. The cartridge of claim 3, wherein the pyridoxines is pyridoxamine.

4. A method for preparing a peritoneal dialysate, comprising:

passing a peritoneal dialysate through a cartridge, wherein the cartridge is filled with pyridoxines or salts thereof immobilized on an insoluble carrier; and

allowing carbonyl compounds in the peritoneal dialysate to be trapped by the pyridoxines or salts thereof thereby reducing carbonyl concentration in the peritoneal dialysate.

8. The method for preparing a peritoneal dialysate having a reduced carbonyl compound content of claim 4, wherein the pyridoxines is pyridoxamine.

5. A method for preparing a peritoneal dialysate having a reduced carbonyl compound content, the method comprising:

(a) contacting the peritoneal dialysate with pyridoxines or salts thereof which is immobilized on an insoluble carrier, and

(b) separating the peritoneal dialysate from the pyridoxines or salts thereof.

9. The method for preparing a peritoneal dialysate having a reduced carbonyl compound content of claim 5, wherein the pyridoxines is pyridoxamine.

6. A peritoneal dialysate present in a dual compartment container wherein a first compartment contains a reducing sugar and a second compartment contains pyridoxines or salts thereof.

10. The peritoneal dialysate of a claim 6, wherein the pyridoxines is pyridoxamine.