Curcumin-Resveratrol hybrid molecule

• US 7,745,670 B2
• Filed: 12/24/2008
• Issued: 06/29/2010
• Est. Priority Date: 06/27/2008
• Status: Expired due to Fees

• Current Assignee: DePuy Synthes Products LLC (Johnson & Johnson)
• Original Assignee: Codman & Shurtleff Incorporated (Johnson & Johnson)
• Inventors: DiMauro, Thomas M.
• Primary Examiner(s): Witherspoon; Sikarl A
• Application Number:
  US12/343,750
• Publication Number:
  US 20090326275A1
• Time in Patent Office: 552 Days
• Field of Search: 568/717, 568/718
• US Class Current: 568/717
• CPC Class Codes: A61P 25/28 for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
• CPC Class Codes: C07C 229/12 to carbon atoms of acyclic carbon skeletons
• CPC Class Codes: C07C 229/34 the carbon skeleton containing six-membered aromatic rings
• CPC Class Codes: C07C 229/36 with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
• CPC Class Codes: C07C 271/54 to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
• CPC Class Codes: C07C 39/21 with at least one hydroxy group on a non-condensed ring

Abstract

Novel molecules based upon hybridization of curcumin and hydroxystilbenes, such as resveratrol. It is believed that these novel molecules will have special application in treating Alzheimer'"'"'s Disease.

Claims

1. 1-hydroxyl 3,5-bis(4′

-hydroxyl styryl)benzene.

2. 1,3-dihydroxyl 4,6-bis(4′

-hydroxyl styryl)benzene.

3. 1-hydroxyl 3,5-bis(3′

,4′

-dihydroxyl styryl)benzene.