Non-invasive systems and methods for the determination of cardiac injury using a characterizing portion of a voxel histogram
First Claim
Patent Images
1. A non-invasive method of evaluating actual and/or potential cardiac injury in a patient, comprising:
- electronically determining, for a plurality of regions of interest in a medical image of a heart, respective locations of voxels in three-dimensional space and an associated respective measure of intensity for each of the voxels;
electronically identifying whether high intensity voxels from the determining step are clustered or distributed in the regions of interest;
evaluating whether there is a likelihood the heart has a global injury using the measures of intensity and spatial coordinate data of the high intensity voxels based on data from the identifying step to determine whether the patient has a change in tissue composition and/or function that is in a substantially randomly distributed pattern and/or in a pattern that is not detectable at a resolution of image slices associated with the medical image; and
providing output of the determined likelihood to a display associated with a clinician workstation.
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Abstract
Methods, systems and circuits predict cardiotoxicity induced cardiac injury prior to an irreversible state by electronically generating at least one histogram of mean intensities of voxels/pixels in an MRI image of a left ventricle myocardium and electronically determining a likelihood of cardiac injury due to cardiotoxicity based on data from the at least one histogram.
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Citations
60 Claims
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1. A non-invasive method of evaluating actual and/or potential cardiac injury in a patient, comprising:
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electronically determining, for a plurality of regions of interest in a medical image of a heart, respective locations of voxels in three-dimensional space and an associated respective measure of intensity for each of the voxels; electronically identifying whether high intensity voxels from the determining step are clustered or distributed in the regions of interest; evaluating whether there is a likelihood the heart has a global injury using the measures of intensity and spatial coordinate data of the high intensity voxels based on data from the identifying step to determine whether the patient has a change in tissue composition and/or function that is in a substantially randomly distributed pattern and/or in a pattern that is not detectable at a resolution of image slices associated with the medical image; and providing output of the determined likelihood to a display associated with a clinician workstation. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11)
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12. A non-invasive method of evaluating actual and/or potential cardiac injury in a patient, comprising:
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electronically determining, for a plurality of regions of interest in a medical image of a heart, a location of voxels in three-dimensional space and an associated respective measure of intensity for each of the voxels; electronically generating a plurality of histograms of voxel intensity, one for each region of interest corresponding to a CMR image slice of cardiovascular tissue of the patient, the histogram having a characterizing predictive portion; and electronically evaluating whether there is a likelihood of present or future cardiac injury based on data from the generating step, wherein the evaluating step comprises evaluating the characterizing predictive portion of the histogram. - View Dependent Claims (13, 14, 15, 16, 17)
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18. A non-invasive method of evaluating actual and/or potential cardiac injury in a patient, comprising:
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electronically determining, for a plurality of regions of interest in a medical image of a heart, a location of voxels in three-dimensional space and an associated respective measure of intensity for each of the voxels; electronically evaluating whether there is a likelihood of present or future cardiac injury based on data from the determining step; obtaining at least one cardiovascular magnetic resonance 3-D (CMR) image to generate voxel data used in the determining and evaluating steps; and administering a chemotherapeutic agent before obtaining the at least one CMR image that is used to generate the voxel data, wherein the evaluating step is carried out to predict the likelihood of an undesired decrease in left ventricular ejection fraction (LVEF) based on a patients cardiotoxicity reaction to the administered chemotherapeutic agent. - View Dependent Claims (19)
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20. A non-invasive method of evaluating actual and/or potential cardiac injury in a patient, comprising:
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electronically determining, for a plurality of regions of interest in a medical image of a heart, a location of voxels in three-dimensional space and an associated respective measure of intensity for each of the voxels; electronically evaluating whether there is a likelihood of present or future cardiac injury based on data from the determining step; obtaining at least one cardiovascular magnetic resonance (CMR) image for the determining step medical image; electronically generating a plurality of histograms of voxel mean intensity using voxel data from the determining step, one for each region of interest, the histograms having a tail characterizing portion; and wherein the evaluating step comprises automatically monitoring the patient'"'"'s cardiotoxicity response to chemotherapy using the characterizing portion of the histogram. - View Dependent Claims (21)
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22. A non-invasive method of evaluating actual and/or potential cardiac injury in a patient, comprising:
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obtaining at least one CMR image that includes a left ventricle myocardium; electronically determining, for a plurality of regions of interest in the CMR image, a location of voxels in three-dimensional space and an associated respective measure of intensity for each of the voxels, wherein the determining step includes electronically interrogating at least substantially all voxels within a contiguous series of short axis slice positions spanning an apex to a base in the at least one CMR image and identifying the intensity and x, y and z coordinate of each voxel in three-dimensional space; electronically generating a non-invasive biopsy image of the patient that can identify locations of voxels of similar intensities within the left ventricle using data from the determining step; and evaluating whether there is a likelihood of present or future cardiac injury based on data from the determining step.
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23. A non-invasive method of evaluating actual and/or potential cardiac injury in a patient, comprising:
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obtaining at least one CMR image that includes a right ventricle myocardium; electronically determining, for a plurality of regions of interest in the CMR image, a location of voxels in three-dimensional space and an associated respective measure of intensity for each of the voxels, wherein the determining step includes electronically interrogating at least substantially all voxels within a contiguous series of short axis slice positions spanning an apex to a base in the at least one CMR image and identifying the intensity and x, y and z coordinate of each voxel in three-dimensional space; electronically generating a non-invasive biopsy image of the patient that can identify locations of voxels of similar intensities within the right ventricle using data from the determining step; and evaluating whether there is a likelihood of present or future cardiac injury based on data from the determining step.
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24. A non-invasive method of evaluating actual and/or potential cardiac injury in a patient, comprising:
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obtaining at least one CMR image; electronically interrogating at least substantially all voxels within a contiguous series of short axis slice positions spanning an apex to a base in the at least one CMR image and identifying an intensity and x, y and z coordinate of each voxel in three-dimensional space; and electronically generating a non-invasive biopsy image of the patient'"'"'s heart that can identify locations of voxels of similar intensities within the heart for use in evaluating whether there is a likelihood of present or future cardiac injury based on data from the interrogating step. - View Dependent Claims (25)
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26. A non-invasive method of evaluating actual and/or potential cardiac injury in a patient, comprising:
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obtaining at least one Magnetic Resonance Imaging (MRI) image and/or X-ray Computed Tomography image of a heart of a patient; electronically determining, for a plurality of regions of interest in the obtained image of the heart, a location of voxels in three-dimensional space and an associated respective measure of intensity for each of the voxels; electronically extracting and storing x, y, and z coordinates of voxel intensity data of each voxel in a myocardium region of the at least one image; electronically adjusting voxel intensity data for background noise in the myocardium region; generating histograms of the regions of interest based on the determining step using data from the extracting and storing step; and electronically evaluating whether there is a likelihood of present or future cardiac injury based on data from the generating histogram step.
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27. A method of predicting cardiac injury prior to an irreversible dysfunctional state, comprising:
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electronically extracting and storing x, y, and z coordinates of voxel intensity data of voxels in multiple slices of an MRI image of a left ventricle myocardium; electronically generating at least one histogram of mean intensities of voxels/pixels using the extracted and stored voxel data; electronically determining a likelihood of cardiac injury due to cardiotoxicity based on data from the at least one histogram; and providing output of the determined likelihood to a display associated with a clinician workstation. - View Dependent Claims (28, 29, 30, 31)
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32. A signal processor circuit comprising:
a signal processor configured to determine a likelihood of cardiac injury of a patient'"'"'s heart due to cardiotoxicity using histograms of mean intensity of voxels from multiple different slices of an MRI or X-ray CT image of cardiac tissue, wherein the histograms represent percentage versus mean intensity of voxels within a region of interest, and wherein the signal processor is configured to evaluate whether the patient has a global cardiac injury using measures of mean intensity and associated spatial coordinate data of the voxels to thereby determine whether the patient has a change in tissue composition and/or function that is in a substantially randomly distributed pattern and/or in a pattern that is not detectable at a resolution of the image slices. - View Dependent Claims (33, 34, 35, 36, 37)
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38. A non-invasive system for evaluating cardiotoxicity, comprising:
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a signal processor in communication with a physician workstation configured to generate at least one histogram of intensity voxels of at least one image of cardiac tissue of a patient and determine the likelihood of cardiac injury due to cardiotoxicity using a characterizing portion, distribution pattern or lineshape of the at least one histogram, wherein the intensity voxels are associated with an MRI or X-ray CT image of cardiac tissue, and wherein the histogram represents percentage versus a measure of intensity of voxels within a region of interest, and wherein the signal processor is configured to evaluate whether the cardiac tissue has a global injury using measures of intensity and spatial coordinate data of the voxels to thereby determine whether the patient has a change in tissue composition and/or function that is in a substantially randomly distributed pattern and/or in a pattern that is not detectable at a resolution of image slices associated with the image of cardiac tissue. - View Dependent Claims (39, 40, 41, 42, 43)
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44. A computer program product for evaluating cardiac injury a patient'"'"'s heart, comprising:
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a computer readable medium having computer readable program code embodied therein, the computer readable program code comprising; computer readable program code configured to determine a likelihood of cardiac injury associated with cardiotoxicity using a characterizing portion of at least one histogram of a measure of intensity of voxels in at least one cardiac image obtained after administration of a contrast agent to the patient, wherein the computer readable program code is configured to evaluate whether the cardiac injury is a global injury using the voxel measures of intensity and associated spatial coordinate data to thereby determine whether the patient has a change in tissue composition and/or function that is in a substantially randomly distributed pattern and/or in a pattern that is not detectable at a resolution of image slices associated with the at least one cardiac image. - View Dependent Claims (45, 46, 47, 48, 49)
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50. A system for non-invasively predicting cardiac injury due to cardiotoxicity prior to an irreversible state of cardiac injury associated with clinical dysfunction:
a signal processor circuit in communication with a display at a physician workstation, the signal processor configured to electronically generate at least one histogram of mean intensity of voxels/pixels in an MRI or CT image and electronically determine a likelihood of cardiac global injury of a patient due to cardiotoxicity based on data from the at least one histogram using measures of intensity and spatial coordinate data to thereby determine whether the patient has a change in tissue composition and/or function that is in a substantially randomly distributed pattern and/or in a pattern that is not detectable at a resolution of image slices associated with the MRI or CT image. - View Dependent Claims (51, 52, 53, 54, 55, 56)
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57. A system for non-invasively predicting injury to an organ due to toxicity:
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a clinician workstation with a display; and a signal processor circuit in communication with the display, the signal processor configured to;
(a) identify measures of intensity of voxels of a target organ and correlate associated x, y and z coordinates of the voxels in three-dimensional space using multiple image slices of at least one imaging modality; and
(b) evaluate whether the target organ has a global injury using the measures of intensity and spatial coordinate data to thereby determine whether the patient has a change in tissue composition and/or function that is in a substantially randomly distributed pattern and/or in a pattern that is not detectable at a resolution of the image slices. - View Dependent Claims (58, 59, 60)
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Specification