System and method of obtaining images and spectra of intracavity structures using 3.0 Tesla magnetic resonance systems

• US 7,747,310 B2
• Filed: 03/13/2003
• Issued: 06/29/2010
• Est. Priority Date: 05/16/2002
• Status: Active Grant

• Current Assignee: DxTx Medical Inc.
• Original Assignee: Medrad Incorporated (Bayer AG)
• Inventors: Rhinehart, Edward J., Misic, George J.
• Primary Examiner(s): Winakur; Eric F
• Assistant Examiner(s): Gupta; Vani
• Application Number:
  US10/483,945
• Publication Number:
  US 20040236209A1
• Time in Patent Office: 2,665 Days
• Field of Search: 600/423, 600/410, 600/421, 600/433, 600/435, 600/424, 600/407, 324/300, 324/306, 324/307, 324/309, 324/314, 324/318, 324/320, 324/322
• US Class Current: 600/423
• CPC Class Codes: A61B 5/055 involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
• CPC Class Codes: G01R 33/285 Invasive instruments, e.g. catheters or biopsy needles, specially adapted for tracking, guiding or visualization by NMR
• CPC Class Codes: G01R 33/34084 implantable coils or coils being geometrically adaptable to the sample, e.g. flexible coils or coils comprising mutually movable parts
• CPC Class Codes: G01R 33/3628 Tuning/matching of the transmit/receive coil

Abstract

An MR system features an intracavity probe and associated interface device. The probe includes a shaft, a balloon at one end thereof, and a coil loop within the balloon. The loop has two drive capacitors and a tuning capacitor, all of which in series. A junction node between the drive capacitors serves as a ground for electrically balancing the loop. Diametrically opposite the node, the tuning capacitor enables the loop to resonate at the operating frequency of the MR system. The interface allows the MR system to couple the loop to a port of the MR system during a receive cycle thereof and decouple it from the port during a transmit cycle thereof. With its balloon inserted and inflated within a cavity of a patient, the probe allows the MR system to generate images and/or spectra of the region of interest using the MR signals received by the loop.

Claims

1. An intracavity probe for use with a magnetic resonance (MR) system for obtaining images or spectra of a region of interest within a cavity of a patient, said intracavity probe comprising:

(a) a coil loop for receiving MR signals from said region of interest, said coil loop having a plurality of capacitors therein, said plurality of capacitors including (i) a first drive capacitor and a second drive capacitor of approximately equal value serially connected within said coil loop and at a junction node thereof forming a virtual ground for electrically balancing and impedance matching said coil loop and (ii) a tuning capacitor serially connected within said coil loop diametrically opposite said junction node of said drive capacitors and having a value selected to resonate said coil loop at an operating frequency of said MR system; and

(b) an output cable for connecting said coil loop to an interface device for said intracavity probe, said output cable at one end thereof being connected across one of said drive capacitors and at an other end thereof having a plug for connection to said interface device, said output cable having an electrical length of n(λ

/2)+S_L wherein n is an integer, λ

is a wavelength of said operating frequency of said MR system, and S_L is a supplemental length whose reactance is of a same magnitude as a reactance of one of said drive capacitors.

2. The intracavity probe of claim 1 further comprising:

(a) a flexible shaft having a tip at a distal end thereof, said tip being substantially more flexible than a remainder of said flexible shaft;

(b) an inner balloon connected to said distal end of said flexible shaft and enclosing said tip thereof;

(c) a non-stretchable material for securing said coil loop to an anterior surface of said inner balloon; and

(d) an outer balloon connected to said distal end of said shaft enclosing both said inner balloon and said coil loop secured thereto, said outer balloon for use in positioning said inner balloon within said cavity of said patient;

such that said non-stretchable material affects inflation of said inner balloon within said outer balloon to enable said coil loop therein to be positioned approximate said region of interest for optimal reception of said MR signals therefrom.

3. The intracavity probe of claim 2 wherein said non-stretchable material focuses inflation of said inner balloon to force a posterior surface of said outer balloon against a wall of said cavity then forcing an anterior surface of said outer balloon against a correspondingly-shaped interior contour of said cavity thereby bringing said coil loop approximate said region of interest for optimal reception of said MR signals therefrom.

4. The intracavity probe of claim 2 wherein said outer balloon has an anterior surface for conformably fitting to a correspondingly-shaped interior contour of said cavity.

5. The intracavity probe of claim 4 wherein said outer balloon has a posterior surface, opposite said anterior surface thereof, comprising at least a pair of undulating folds.

6. The intracavity probe of claim 5 further comprising a means for controlling inflation of said inner balloon, said inflation control means being connected to said flexible shaft through which a gas can be conveyed to inflate and deflate said inner balloon.

7. The intracavity probe of claim 6 wherein said inflation control means includes a stop cock for controlling passage of said gas therethrough and release of said gas therefrom.

8. The intracavity probe of claim 6 wherein said flexible shaft includes:

(a) a first lumen for interconnecting said inflation control means and said inner balloon; and

(b) a second lumen through which said output cable is routed from said coil loop to be made available for connection to said interface device for said intracavity probe.

9. The intracavity probe of claim 8 wherein said inflation control means comprises a compressible inflator cuff and a tube therewith connected to said first lumen of said flexible shaft to deliver said gas to said inner balloon upon compression of said inflator cuff.

10. The intracavity probe of claim 5 wherein said non-stretchable material focuses inflation of said inner balloon to force said undulating folds of said outer balloon posteriorly against a wall of said cavity then forcing said anterior surface of said outer balloon anteriorly against said correspondingly-shaped interior contour of said cavity thereby bringing said coil loop approximate said region of interest for optimal reception of said MR signals therefrom.

11. The intracavity probe of claim 10 wherein said anterior surface of said outer balloon is saddle-shaped and said correspondingly-shaped interior contour of said cavity is a rectal prostatic bulge of said patient.

12. The intracavity probe of claim 2 wherein said flexible shaft includes a scale printed on an outer surface thereof.

13. The intracavity probe of claim 2 wherein said inner and said outer balloons each comprise a non-paramagnetic, flame retardant, biocompatible medical grade material having low dielectric loss characteristics.

14. The intracavity probe of claim 2 further comprising an anti-migration disc attachable to said flexible shaft for preventing unwanted movement of said intracavity probe relative to said cavity of said patient.

15. The intracavity probe of claim 14 wherein said anti-migration means is a disc having a semi-spherical shape, said disc defining a slot for allowing said disc to be snapped onto said flexible shaft.

16. The intracavity probe of claim 2 further comprising a dilator element slidably mounted on said flexible shaft for dilating an orifice leading to said cavity to allow easy positioning of said intracavity probe within said cavity.

17. The intracavity probe of claim 2 wherein said outer balloon further comprises lateral indentations therein on which said coil loop at least partially rests when said outer balloon is uninflated.

18. The intracavity probe of claim 1 further comprising:

(a) a flexible shaft;

(b) an inflatable balloon connected to a distal end of said flexible shaft, said inflatable balloon having (i) an anterior surface conformable to a correspondingly-shaped interior contour of said cavity and (ii) a posterior surface comprising at least a pair of undulating folds; and

(c) said coil loop secured within said inflatable balloon approximate an underside of said anterior surface thereof;

such that when said inflatable balloon is inserted into said cavity and inflated said undulating folds thereof press against a wall of said cavity generally opposite said region of interest thus forcing said anterior surface of said inflatable balloon against said correspondingly-shaped interior contour of said cavity thereby bringing said coil loop approximate said region of interest for optimal reception of said MR signals therefrom.

19. The intracavity probe of claim 1 wherein said first and said second drive capacitors each have a value in a range of approximately 62 pF to 82 pF and said tuning capacitor has a value in a range of approximately 12 pF to 15 pF.

20. The intracavity probe of claim 1 wherein said interface device includes a PIN diode capable of being biased by said MR system so that said coil loop via said output cable can be (i) coupled to a signal processing port of said MR system during a receive cycle of said MR system and (ii) decoupled from said signal processing port during a transmit cycle of said MR system.

21. The intracavity probe of claim 20 wherein forward biasing of said PIN diode causes resonance of an inductance of said output cable and a capacitance of one of said drive capacitors to open circuit effectively said coil loop and thereby decouple said intracavity probe from said signal processing port of said MR system during said transmit cycle.