Electrical stimulation treatment of bronchial constriction

• US 7,747,324 B2
• Filed: 11/01/2006
• Issued: 06/29/2010
• Est. Priority Date: 11/10/2005
• Status: Active Grant

• Current Assignee: electroCore, Inc.
• Original Assignee: Electrocore, Llc
• Inventors: Errico, Joseph P., Mendez, Steven, Pastena, James R., Ross, Arthur, Hu, Hecheng
• Primary Examiner(s): Schaetzle; Kennedy J
• Assistant Examiner(s): SARCIONE, JESSICA LYNN
• Application Number:
  US11/591,340
• Publication Number:
  US 20070106339A1
• Time in Patent Office: 1,336 Days
• Field of Search: 607/42
• US Class Current: 607/42
• CPC Class Codes: A61N 1/3601 of respiratory organs
• CPC Class Codes: A61N 1/3611 Respiration control stimulating respiratory organs A61N1/3601
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362

Abstract

Methods and devices for treating bronchial constriction related to asthma and anaphylaxis wherein the treatment includes providing an electrical impulse to a selected region of the vagus nerve and/or the lungs of a patient suffering from bronchial constriction.

Claims

1. A method of treating bronchial constriction associated with asthma or anaphylaxis comprising applying at least one electrical impulse to a selected region of a vagus nerve of a mammal in need of relief of bronchial smooth muscle constriction whereby a magnitude of constriction of the smooth muscle is reduced, wherein the electrical impulse has a frequency of 15 Hz to 35 Hz inclusive.

2. The method set forth in claim 1 wherein the selected region comprises an anterior pulmonary plexus.

3. The method set forth in claim 1 wherein the selected region comprises a posterior pulmonary plexus.

4. The method set forth in claim 1 wherein the selected region comprises a region of the vagus nerve proximal to a cardiac branch of the vagus nerve.

5. The method set forth in claim 1 wherein the selected region comprises a region of the vagus nerve proximal to a pulmonary branch of the vagus nerve.

6. A method of treating bronchial constriction associated with anaphylactic shock or asthma, comprising applying at least one electrical impulse to one or more selected regions of a vagus nerve of a mammal in need of relief of bronchial constriction, wherein the electrical impulse has a frequency of between 15 Hz to 35 Hz inclusive.

7. The method of claim 6, further comprising:

implanting one or more electrodes to the one or more selected regions of the vagus nerve; and

applying one or more electrical stimulation signals to the one or more electrodes to produce the at least one electrical impulse,

wherein the one or more electrical stimulation signals are of an amplitude of between 0.2 to 20 volts.

8. The method of claim 6, wherein the one or more electrical stimulation signals are of an amplitude of between 0.75 to 1.25 volts inclusive.

9. The method of claim 6, wherein the one or more electrical stimulation signals are one or more of a full or partial sinusoid, square wave, rectangular wave, triangle wave.

10. The method of claim 6, wherein the one or more electrical stimulation signals have a pulsed on-time of between 50 to 500 microseconds inclusive.

11. The method of claim 6, wherein the one or more electrical stimulation signals have a frequency of 25 Hz, and a pulsed on-time of 200-400 microseconds inclusive.

12. The method of claim 6, wherein the one or more electrical stimulation signals have a frequency of 25 Hz, and a pulsed on-time of between 100 to 400 microseconds inclusive.

13. The method of claim 12, wherein the pulsed on-time is one of:

400 microseconds, 200 microseconds, and 100 microseconds.