Method, system and software application for electrochemical analysis

• US 7,747,402 B2
• Filed: 02/11/2005
• Issued: 06/29/2010
• Est. Priority Date: 02/11/2005
• Status: Active Grant

• Current Assignee: Dionex Corporation (Thermo Fisher Scientific Incorporated)
• Original Assignee: Dionex Corporation (Thermo Fisher Scientific Incorporated)
• Inventors: Fan, Der-Min, Yeung, Henry Hon-Kit, Gragg, Damon R., Baron, Ronald Steven, White, Raymond Gordon, Modic, Walter Douglas
• Primary Examiner(s): Charioui; Mohamed
• Application Number:
  US11/056,839
• Publication Number:
  US 20060180478A1
• Time in Patent Office: 1,964 Days
• Field of Search: 702/23, 702/27, 702/30, 702/64, 702/66, 702/67, 702/179, 205/775, 205/118, 600/365
• US Class Current: 702/67
• CPC Class Codes: G01N 27/404 Cells with anode, cathode and cell electrolyte on the same side of a permeable membrane which separates them from the sample fluid , e.g. Clark-type oxygen sensors
• CPC Class Codes: G01N 27/49 Systems involving the determination of the current at a single specific value, or small range of values, of applied voltage for producing selective measurement of one or more particular ionic species

Abstract

Electrochemical analysis is performed by applying one or more time-sequenced voltage waveforms in a solution and measuring the resulting current in the solution. Raw data representative of the measured current parameters may be integrated based on one or more integration time intervals, and the raw data may be displayed in one or more three dimensional plots. The integrated data and the raw data may also be displayed in one or more two-dimensional plots. The raw data is stored for three dimensional displays and the integrated data is stored for two dimensional displays. Baseline correction is performed on the raw data and the baseline corrected data is displayed in one or more three dimensional plots and in one or more two dimensional plots. The raw data is stored at a rate between 100 Hz and 10 KHz.

Claims

1. A computer-implemented method for analyzing and displaying data comprising:

at a computer,

first, receiving raw data from electrochemical analysis performed by a separate test device by applying one or more voltage waveforms on analyte(s), wherein the raw data is representative of current parameters measured in the analyte(s);

second, storing the received raw data;

third, receiving one or more user-selected processing parameters;

fourth, processing the raw data based on the one or more user-selected processing parameters to produce processed data, wherein the raw data that is processed includes portions of the raw data received prior to the selection by the user of the processing parameters; and

fifth, providing a response based on the processed data.

2. The method of claim 1, further comprising:

at the computer,

receiving a user-defined adjustment to at least one of the user-selected processing parameters;

processing the raw data based on the user-defined adjustment; and

providing an adjusted response based on the processing.

3. The method of claim 2, wherein the one or more user-selected processing parameters include one or more integration time intervals, and wherein processing the raw data includes integrating the raw data based on the one or more integration time intervals to generate integrated data.

4. The method of claim 3, further comprising performing arithmetic operations on the integrated data.

5. The method of claim 3, wherein providing a response based on the processing includes:

displaying a magnitude of the integrated data as a function of time in a two-dimensional plot.

6. The computer-implemented method of claim 1, further comprising:

displaying the raw data in a first plot as a function of time; and

wherein receiving one or more user-selected processing parameters comprises receiving a user'"'"'s selection of a portion of the first plot.

7. The computer-implemented method of claim 6, wherein providing a response comprises displaying processed data in a second plot while simultaneously displaying the first plot.

8. The method of claim 1, further comprising performing baseline correction of the raw data, and displaying the baseline corrected data in a three dimensional display.

9. The method of claim 1, wherein one or more processing parameters include one or more arithmetic operations, and wherein processing the raw data includes performing the one or more arithmetic operations on the raw data.

10. The method of claim 1, further comprising:

displaying the raw data in at least one three-dimensional plot as a function of a time interval of the electrochemical analysis and a duration of the application of the one or more voltage waveforms.

11. The method of claim 1, further comprising:

displaying the raw data of a first waveform of the one or more voltage waveforms in at least one two-dimensional plot as a function of a duration of the application of the first waveform.

12. A computer readable storage medium having one or more programs configured for execution by a computer, the one or more programs comprising instructions for:

first, receiving raw data from electrochemical analysis performed by a separate test device by applying one or more voltage waveforms on analyte(s), wherein the raw data is representative of current parameters measured in the analyte(s);

second, storing the received raw data;

third, receiving one or more user-selected processing parameters;

fourth, processing the raw data based on the one or more user-selected processing parameters to produce processed data, wherein the raw data that is processed includes portions of the raw data received prior to the selection by the user of the processing parameters; and

fifth, generating a response based on the processed data.

13. The computer readable medium of claim 12, further including instructions for:

receiving a user-defined adjustment to at least one of the user-selected processing parameters;

processing the raw data based on the user-defined adjustment; and

generating an adjusted response based on the processing of the raw data.

14. The computer readable medium of claim 13, wherein the one or more processing parameters include one or more integration time intervals, and wherein processing the raw data includes integrating the raw data based on the one or more integration time intervals to generate integrated data.

15. The computer readable medium of claim 14, further comprising instructions for performing arithmetic operations on the integrated data.

16. The computer readable medium of claim 14, further comprising instructions for receiving a user-defined adjustment to the one or more integration time intervals, and in response, modifying the one or more integration time intervals.

17. The computer readable medium of claim 14, further comprising instructions for re-integrating the raw data with different integration parameters to provide the adjusted response.

18. The computer readable medium of claim 14, wherein instructions for providing a response based on the processing include:

instructions for displaying a magnitude of the integrated data as a function of time in a two-dimensional plot.

19. The computer readable storage medium of claim 12, further comprising:

instructions for displaying the raw data in a first plot as a function of time; and

wherein instructions for receiving one or more user-selected processing parameters comprises instructions for receiving a user'"'"'s selection of a portion of the first plot.

20. The computer readable storage medium of claim 19, further comprising:

instructions for providing a response comprises instructions for displaying processed data in a second plot while simultaneously displaying the first plot.

21. The computer readable medium of claim 12, further comprising instructions for performing baseline correction of the raw data, and for displaying the baseline corrected data in three dimensional plots and two dimensional plots.

22. The computer readable medium of claim 12, wherein one or more processing parameters include one or more arithmetic operations, and wherein processing the raw data includes performing the one or more arithmetic operations on the raw data.

23. The computer readable medium of claim 12, further including instructions for:

displaying the raw data in at least one three-dimensional plot as a function of a time interval of the electrochemical analysis and a duration of the application of the one or more voltage waveforms.

24. The computer readable medium of claim 12, further including instructions for:

displaying the raw data of a first waveform of the one or more voltage waveforms in at least one two-dimensional plot as a function of a duration of the application of the first waveform.

25. A system comprising:

a processor circuit configured to generate at least one digital voltage waveform;

a first converter circuit configured to receive the digital voltage waveform and responsively to generate an analog voltage waveform;

at least one first electrode configured to receive the analog voltage waveform and responsively to apply the analog voltage waveform to analyte(s) and to measure the resulting current signal in the analyte(s);

a second converter circuit configured to receive the measured current signal and responsively to generate raw data representative of the measured current signal;

a computer having an associated computer-readable storage medium to store one or more programs configured for execution by a computer, the one or more programs comprising instructions for;

first, receiving the raw data;

second, storing the received raw data;

third, receiving one or more user-selected processing parameters;

fourth, processing the raw data based on the one or more user-selected processing parameters to produce processed data, wherein the raw data that is processed includes portions of the raw data received prior to the selection by the user of the processing parameters; and

fifth, providing a response based on the processed data.

26. The system of claim 25, further including instructions for:

receiving a user-defined adjustment to at least one of the user-selected processing parameters;

processing the raw data based on the user-defined adjustment; and

providing an adjusted response based on the processing.

27. The system of claim 26, wherein the one or more user selected processing parameters include one or more integration time intervals, and wherein processing the raw data includes integrating the raw data based on the one or more integration time intervals to generate integrated data.

28. The system of claim 27, wherein instructions for providing a response based on the processing include:

instructions for displaying the integrated data and the raw data in at least one two-dimensional plot.

29. The system of claim 27, wherein instructions for providing a response based on the processing include:

instructions for displaying a magnitude of the integrated data as a function of time in a two-dimensional plot.

30. The system of claim 26, further comprising:

a user interface operable to receive the one or more user-selected processing parameters and the user-defined adjustment.

31. The system claim 26, further comprising instructions for:

performing baseline correction of the raw data, and displaying the baseline corrected data in a three dimensional display.

32. The system claim 25, further comprising:

instructions for displaying the raw data in a first plot as a function of time; and

wherein instructions for receiving one or more user-selected processing parameters comprises instructions for receiving a user'"'"'s selection of a portion of the first plot.

33. The system of claim 32, further comprising:

instructions for providing a response comprises instructions for displaying processed data in a second plot while simultaneously displaying the first plot.

34. The system of claim 25, further comprising a summing circuit coupled to the first converter circuit and adapted to receive the reference voltage and the analog voltage waveform and responsive to generate a resultant voltage waveform, and wherein the resultant voltage waveform is applied to the analytes.

35. The system of claim 25, wherein one or more user selected processing parameters include one or more arithmetic operations, and wherein processing the raw data includes performing the one or more arithmetic operations on the raw data.

36. The system of claim 25, further including instructions for:

displaying the raw data in at least one three-dimensional plot as a function of a time interval of the electrochemical analysis and a duration of the application of the one or more voltage waveforms.

37. The system of claim 25, further including instructions for:

displaying the raw data of a first waveform of the one or more voltage waveforms in at least one two-dimensional plot as a function of a duration of the application of the first waveform.