Reinforced absorbable multilayered fabric for use in tissue repair and regeneration

• US 7,749,204 B2
• Filed: 10/17/2005
• Issued: 07/06/2010
• Est. Priority Date: 10/20/2004
• Status: Active Grant

• Current Assignee: Ethicon Incorporated (Johnson & Johnson)
• Original Assignee: Ethicon Incorporated (Johnson & Johnson)
• Inventors: Pendharkar, Sanyog Manohar, Do, Hiep, Shetty, Dhanuraj S., Dhanaraj, Sridevi
• Primary Examiner(s): Stephens; Jacqueline F.
• Application Number:
  US11/252,176
• Publication Number:
  US 20060084930A1
• Time in Patent Office: 1,723 Days
• Field of Search: 604/305, 604/307
• US Class Current: 604/305
• CPC Class Codes: A61F 13/00 Bandages or dressings radioactive dressings A61N5/1029; Absorbent pads
• CPC Class Codes: A61F 2/0063 Implantable repair or support meshes, e.g. hernia meshes
• CPC Class Codes: A61F 2013/00604 Multilayer
• CPC Class Codes: A61F 2013/00927 with biological activity, e.g. enzymes for debriding wounds or others, collagen or growth factors
• CPC Class Codes: A61L 15/26 Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof A61L15/225 takes precedence
• CPC Class Codes: A61L 15/28 Polysaccharides or their derivatives A61L15/225 takes precedence
• CPC Class Codes: A61L 2430/06 for cartilage reconstruction, e.g. meniscus
• CPC Class Codes: A61L 2430/10 for reconstruction of tendons or ligaments
• CPC Class Codes: A61L 2430/24 for joint reconstruction
• CPC Class Codes: A61L 27/18 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
• CPC Class Codes: A61L 27/20 Polysaccharides
• CPC Class Codes: A61L 27/48 with macromolecular fillers
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body
• CPC Class Codes: A61L 31/042 Polysaccharides
• CPC Class Codes: A61L 31/06 obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds A61L31/041 takes precedence
• CPC Class Codes: A61P 17/02 for treating wounds, ulcers, burns, scars, keloids, or the like
• CPC Class Codes: B32B 2250/02 2 layers
• CPC Class Codes: B32B 2250/20 All layers being fibrous or filamentary
• CPC Class Codes: B32B 2262/0276 Polyester fibres
• CPC Class Codes: B32B 2262/04 Cellulosic plastic fibres, e.g. rayon
• CPC Class Codes: B32B 2262/06 : Vegetal fibres
• CPC Class Codes: B32B 2307/726 : Permeability to liquids, absorption
• CPC Class Codes: B32B 2459/00 : Nets, e.g. camouflage nets
• CPC Class Codes: B32B 2535/00 : Medical equipment, e.g. bandage, prostheses, catheter medical patches B32B2556/00
• CPC Class Codes: B32B 5/022 : Non-woven fabric
• CPC Class Codes: B32B 5/024 : Woven fabric
• CPC Class Codes: B32B 5/026 : Knitted fabric
• CPC Class Codes: B32B 5/06 : characterised by a fibrous or filamentary layer mechanically connected, e.g. by needling to another layer, e.g. of fibres, of paper
• CPC Class Codes: B32B 5/10 : characterised by a fibrous or filamentary layer reinforced with filaments
• CPC Class Codes: B32B 5/26 : another layer next to it also being fibrous or filamentary relative arrangement of fibres or filaments of different layers B32B5/12
• CPC Class Codes: B32B 9/04 : comprising such particular substance as the main or only constituent of a layer, which is next to another layer of the same or of a different material next to a glass layer B32B17/06; layered products with at least two ceramic layers composed mainly of ceramic B32B18/00
• CPC Class Codes: C08L 1/00 : Compositions of cellulose, modified cellulose or cellulose derivatives
• CPC Class Codes: C08L 1/04 : Oxycellulose; Hydrocellulose , e.g. microcrystalline cellulose
• CPC Class Codes: C08L 1/24 : Viscose
• CPC Class Codes: C08L 67/04 : Polyesters derived from hydroxycarboxylic acids, e.g. lactones C08L67/06 takes precedence
• CPC Class Codes: D04H 1/435 : Polyesters
• CPC Class Codes: D04H 1/4374 : using different kinds of webs, e.g. by layering webs
• CPC Class Codes: Y10T 442/3707 : Woven fabric including a nonwoven fabric layer other than paper
• CPC Class Codes: Y10T 442/494 : Including a nonwoven fabric layer other than paper

Abstract

The present invention is directed to a method of using a multilayered fabric comprising a first absorbable nonwoven fabric and a second absorbable woven or knitted fabric in tissue repair and regeneration.

Claims

1. A method of tissue repair and regeneration, said method comprising:

preparing a repair site for implantation, providing a reinforced absorbable multilayered fabric, said fabric comprising;

a first absorbable nonwoven fabric comprising staple having a length from about 1.5 to 2 inches, and a second absorbable woven or knitted fabric, and disposing said fabric at said site.

2. The method of claim 1, where said reinforced absorbable multilayered fabric is attached to said site of repair with suture, tack, or biocompatible glue.

3. The method of claim 1, where said first absorbable nonwoven fabric of said multilayered fabric comprises fibers comprised of aliphatic polyester polymers or copolymers of one or more monomers selected from the group consisting of lactic acid, lactide (including L-, D-, meso and D, L mixtures), glycolic acid, glycolide, .epsilon.-caprolactone, p-dioxanone, and trimethylene carbonate.

4. The method of claim 3, where said first absorbable nonwoven fabric comprises glycolide/lactide copolymer.

5. The method of claim 3, where said second absorbable woven or knitted fabric of said multilayered fabric comprises oxidized polysaccharides.

6. The method of claim 5, where said second absorbable woven or knitted fabric comprises oxidized cellulose.

7. The method of claim 5, where said second absorbable woven or knitted fabric comprises oxidized regenerated cellulose.

8. The method of claim 1, where said first absorbable nonwoven fabric comprises glycolide/lactide copolymer, and said second absorbable woven or knitted fabric comprises oxidized regenerated cellulose.

9. The method of claim 1, where said staple is crimped.

10. The method of claim 1, where said staple is derived from fiber of about 1 to 4 denier per filament.

11. The method of claim 10, where said first absorbable nonwoven fabric has a basis weight of about 0.01 to 0.2 g/in.sup.2;

and said second absorbable woven or knitted fabric has a basis weight of about 0.001 to 0.2 g/in.sup.2.

12. The method of claim 1, where said reinforced absorbable multilayered fabric further comprises a bioactive agent selected from the group consisting of integrin binding sequence, ligands, bone morphogenic proteins, epidermal growth factor, IGF-I, IGF-II, TGF-.beta. I-Ill, growth differentiation factor, parathyroid hormone, vascular endothelial growth factor, hyaluronic acid, glycoprotein, lipoprotein, bFGF, TGF-beta superfamily factors, BMP-2, BMP-4, BMP-6, BMP-12, sonic hedgehog, GDF5, GDF6, GDF8, PDGF, recombinant human growth and differentiation factor 5, tenascin-C, fibronectin, thromboelastin, thrombin-derived peptides, heparin-binding domains, demineralized bone matrix, platelet rich plasma, bone marrow aspirate, and bone fragments.

13. The method of claim 1, where said reinforced absorbable multilayered fabric further comprises cells selected from the group consisting of bone marrow cells, stromal cells, stem cells, embryonic stem cells, chondrocytes, osteoblasts, osteocytes, osteoclasts, fibroblasts, pluripotent cells, chondrocyte progenitors, endothelial cells, macrophages, leukocytes, 5 adipocytes, monocytes, plasma cells, mast cells, umbilical cord cells, postpartum derived cells, mesenchymal stem cells, epithelial cells, myoblasts, and precursor cells derived from adipose tissue.