Mutant IL-10
First Claim
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1. An isolated mutant IL-10 polypeptide, wherein the polypeptide comprises the amino acid sequence of SEQ ID NO:
- 2 or SEQ ID NO;
3 with a substitution of serine for phenylalanine at position 129 of SEQ ID NO;
2 or SEQ ID NO;
3.
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Accused Products
Abstract
IL-10 sequence variants are disclosed that retain the therapeutically desirable anti-inflammatory properties of wild-type IL-10 but do not retain the hemoatopoeitic cell regulatory and cell proliferative activities. The mutant IL-10 polypeptides of the invention are used in methods of treating diseases involving inflammatory response, including neuropathic pain and other neurological disorders.
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Citations
4 Claims
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1. An isolated mutant IL-10 polypeptide, wherein the polypeptide comprises the amino acid sequence of SEQ ID NO:
- 2 or SEQ ID NO;
3 with a substitution of serine for phenylalanine at position 129 of SEQ ID NO;
2 or SEQ ID NO;
3. - View Dependent Claims (2)
- 2 or SEQ ID NO;
- 3. An isolated mutant IL-10 polypeptide, wherein the polypeptide comprises the amino acid sequence of SEQ ID NO:
Specification