Arrays formed of encoded beads having ligands attached
First Claim
1. An ordered planar array comprising several different particle types with different ligands attached to different particle types, said particles up to 10 microns in diameter, wherein different particle types are randomly distributed throughout the array, and said particles are encoded with a characteristic that permits identification of the ligand or ligands attached thereto and permits distinguishing the individual particles including distinguishing different particles from each other, and wherein said particles'"'"' positions are immobilized on said substrate such that said particles form planar hexagonal crystalline configurations.
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Abstract
A method and apparatus for the manipulation of colloidal particles and biomolecules at the interface between an insulating electrode such as silicon oxide and an electrolyte solution. Light-controlled electrokinetic assembly of particles near surfaces relies on the combination of three functional elements: the AC electric field-induced assembly of planar aggregates; the patterning of the electrolyte/silicon oxide/silicon interface to exert spatial control over the assembly process; and the real-time control of the assembly process via external illumination. The present invention provides a set of fundamental operations enabling interactive control over the creation and placement of planar arrays of several types of particles and biomolecules and the manipulation of array shape and size. The present invention enables sample preparation and handling for diagnostic assays and biochemical analysis in an array format, and the functional integration of these operations. In addition, the present invention provides a procedure for the creation of material surfaces with desired properties and for the fabrication of surface-mounted optical components.
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Citations
20 Claims
- 1. An ordered planar array comprising several different particle types with different ligands attached to different particle types, said particles up to 10 microns in diameter, wherein different particle types are randomly distributed throughout the array, and said particles are encoded with a characteristic that permits identification of the ligand or ligands attached thereto and permits distinguishing the individual particles including distinguishing different particles from each other, and wherein said particles'"'"' positions are immobilized on said substrate such that said particles form planar hexagonal crystalline configurations.
Specification