Antibody drug conjugate metabolites

• US 7,750,116 B1
• Filed: 02/20/2007
• Issued: 07/06/2010
• Est. Priority Date: 02/18/2006
• Status: Active Grant

• Current Assignee: Seagen Inc. (Pfizer Inc.)
• Original Assignee: Seattle Genetics Incorporated (Pfizer Inc.)
• Inventors: Doronina, Svetlana O., Alley, Stephen C.
• Primary Examiner(s): HUFF, SHEELA JITENDRA
• Application Number:
  US11/677,029
• Time in Patent Office: 1,232 Days
• Field of Search: None
• US Class Current: 530/330
• CPC Class Codes: A61K 47/6809 Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
• CPC Class Codes: A61K 47/6811 the drug being a protein or peptide, e.g. transferrin or bleomycin
• CPC Class Codes: A61P 35/00 Antineoplastic agents
• CPC Class Codes: C07K 5/06052 Val-amino acid

Abstract

Methods of treating a refractory or drug resistant cancer, cell proliferative disorder and tumor cells are provided. Also provided are antibody drug conjugate metabolites.

Claims

1. A purified compound having the formula: