Antibodies that bind to the C35 polypeptide
First Claim
1. An antibody or antigen binding fragment thereof comprising a heavy chain variable domain and a light chain variable domain, wherein said heavy chain variable domain comprises the same three CDRs encoded by a polynucleotide having the sequence of SEQ ID NO:
- 151; and
wherein said light chain variable domain comprises the same three CDRs encoded by a polynucleotide having the sequence of SEQ ID NO;
150, and wherein said antibody or antigen binding fragment thereof specifically binds C35.
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Abstract
The present invention relates to a novel human gene that is differentially expressed in human carcinoma. More specifically, the present invention relates to a polynucleotide encoding a novel human polypeptide named C35 that is overexpressed in human breast and bladder carcinoma. This invention also relates to C35 polypeptide, in particular C35 peptide epitopes and C35 peptide epitope analogs, as well as vectors, host cells, antibodies directed to C35 polypeptides, and the recombinant methods for producing the same. The present invention further relates to diagnostic methods for detecting carcinomas, including human breast carcinomas. The present invention further relates to the formulation and use of the C35 gene and polypeptides, in particular C35 peptide epitopes and C35 peptide epitope analogs, in immunogenic compositions or vaccines, to induce antibody or cell-mediated immunity against target cells, such as tumor cells, that express the C35 gene. The invention further relates to screening methods for identifying agonists and antagonists of C35 activity.
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Citations
29 Claims
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1. An antibody or antigen binding fragment thereof comprising a heavy chain variable domain and a light chain variable domain, wherein said heavy chain variable domain comprises the same three CDRs encoded by a polynucleotide having the sequence of SEQ ID NO:
- 151; and
wherein said light chain variable domain comprises the same three CDRs encoded by a polynucleotide having the sequence of SEQ ID NO;
150, and wherein said antibody or antigen binding fragment thereof specifically binds C35. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
- 151; and
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10. A method of producing an antibody or antigen binding fragment thereof that specifically binds C35 comprising:
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(a) culturing a host cell, wherein said host cell comprises an expression vector, wherein said expression vector comprises a polynucleotide encoding an antibody or antigen binding fragment thereof comprising a heavy chain variable domain and a light chain variable domain, wherein said heavy chain variable domain comprises the same three CDRs encoded by SEQ ID NO;
151, wherein said light chain variable domain comprises the same three CDRs encoded by SEQ ID NO;
150, and wherein said antibody or antigen binding fragment thereof specifically binds C35; and(b) recovering said antibody or antigen binding fragment thereof from said host cell. - View Dependent Claims (11, 12, 13, 14)
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Specification