Fluid delivery device with autocalibration

• US 7,753,874 B2
• Filed: 12/29/2008
• Issued: 07/13/2010
• Est. Priority Date: 10/09/2002
• Status: Expired due to Term

• Current Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories)
• Original Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories)
• Inventors: Rush, Benjamin
• Primary Examiner(s): Lucchesi; Nicholas D
• Assistant Examiner(s): BERDICHEVSKY, AARTI
• Application Number:
  US12/345,603
• Publication Number:
  US 20090177160A1
• Time in Patent Office: 561 Days
• Field of Search: 604/65, 604/121, 604/122, 604/134, 604/151, 604/152, 604/67
• US Class Current: 604/67
• CPC Class Codes: A61M 2205/0288 Electro-rheological or magneto-rheological materials
• CPC Class Codes: A61M 2205/3317 Electromagnetic, inductive or dielectric measuring means
• CPC Class Codes: A61M 2205/702 automatically during use
• CPC Class Codes: A61M 5/14216 Reciprocating piston type
• CPC Class Codes: A61M 5/14244 adapted to be carried by the patient, e.g. portable on the body
• CPC Class Codes: F04B 2205/09 Flow through the pump
• CPC Class Codes: F04B 43/043 Micropumps
• CPC Class Codes: F04B 49/065 and making use of computers
• CPC Class Codes: F04B 51/00 Testing machines, pumps, or pumping installations
• CPC Class Codes: F05C 2251/08 Shape memory
• CPC Class Codes: G01F 1/708 Measuring the time taken to traverse a fixed distance
• CPC Class Codes: G01F 11/029 provided with electric controlling means G01F11/022 and G01F11/024 take precedence
• CPC Class Codes: G01F 25/0084 for measuring volume
• CPC Class Codes: G01F 25/10 of flowmeters
• CPC Class Codes: G05D 7/0694 by action on throttling means or flow sources of very small size, e.g. microfluidics microvalves F16K99/0001; microstructural devices per se B81B

Abstract

A micro fluid delivery device is particularly useful in medical applications. The device may be worn or carried by the user and may deliver drugs or other medicaments to the user or patient. The device has a control system that accepts input from the user and controls all aspects of operation of the device. The control system measures the output of the pump and adjusts the output of the pump to achieve the desired dosage rate and size. This eliminates differences from pump to pump that result from inevitable variations in the manufacturing of such small scale affordable devices.

Claims

1. A method of delivering a dosage of liquid with a piston actuated pump, the piston having a stroke length, the method comprising:

measuring a flow rate of the pump;

determining a flow characteristic of the liquid substantially simultaneously with measuring the flow rate of the pump, wherein the flow characteristic of the liquid corresponds to a rate of an electrochemical reaction of a component of the liquid;

determining a desired dosage;

determining a number of strokes corresponding to the desired dosage, wherein the determined number of strokes is based, at least in part, on the measured flow rate and the determined flow characteristic of the liquid; and

delivering the desired dosage by moving the piston the corresponding number of strokes.

2. The method of claim 1, wherein measuring the flow rate comprises detecting a constituent in a liquid with one or more electrodes.

3. The method of claim 1, wherein the liquid is insulin.

4. The method of claim 1, wherein determining a desired dosage includes automatically determining a desired dosage.

5. The method of claim 1, wherein determining a desired dosage includes receiving user input corresponding to the desired dosage.

6. The method of claim 1, wherein moving the piston comprises altering the shape of a shape memory actuator by applying a potential to the actuator.

7. The method of claim 6, further comprising altering the potential based upon feedback from a signal from one or more sensors indicative of the position of the piston.

8. The method of claim 1, wherein measuring the flow rate comprises:

actuating the pump;

noting when liquid moved by the pump passes a first sensor; and

noting when liquid moved by the pump passes a second sensor.

9. The method of claim 8, wherein a volume of a portion of the pump between the first and second sensor is known and measuring the flow rate further comprises calculating the number of times the piston is actuated in order to produce the known volume.

10. A method of delivering a liquid, the method comprising:

measuring a flow rate of the liquid by determining when the liquid passes a first sensor having a plurality of electrodes and second sensor having a plurality of electrodes;

determining a flow characteristic of the liquid substantially simultaneously with measuring the flow rate of the liquid;

receiving a desired dosage amount;

determining a number of strokes of a piston required to give the desired amount, wherein the determined number of strokes is based, at least in part, on the measured flow rate and the determined flow characteristic; and

moving the piston the determined number of strokes to deliver the liquid.

11. The method of claim 10, wherein the liquid is insulin.

12. The method of claim 10, wherein the flow characteristic of the liquid corresponds to a voltage of a reaction rate associated with a component of the liquid.

13. The method of claim 10, wherein moving the piston comprises altering the shape of a shape memory actuator by applying a potential to the actuator.

14. The method of claim 10, wherein the plurality of electrodes of the first sensor and the plurality of electrodes of the second sensor are configured to detect an interruption in a flow stream of the liquid.

15. A device for delivering a dosage of liquid, the device comprising:

a piston actuated pump, wherein the piston has a stroke length;

a first sensor and a second sensor for measuring a flow rate of the liquid;

a third sensor for determining a flow characteristic of the liquid;

a shape memory element configured to move the piston from a first point in a stroke length to a second point in a stroke length; and

a processor configured to;

determine a desired dosage;

determine a number of strokes corresponding to the desired dosage, wherein the determined number of strokes is based, at least in part on the measured flow rate and the determined flow characteristic; and

actuate the shape memory element to move the piston the determined number of strokes.

16. The device of claim 15, further comprising a linear feedback switch, wherein the linear feedback switch monitors the piston when the piston is actuated for the determined number of strokes.

17. The device of claim 15, wherein each of the first sensor and the second sensor have a plurality of electrodes.

18. The device of claim 17, wherein the plurality of electrodes of the first sensor and the second sensor are configured to detect an interruption in a dosage of liquid.

19. The device of claim 15, wherein the flow characteristic of the liquid corresponds to a voltage of a reaction rate associated with a component of the liquid.

20. The device of claim 19, wherein actuating the shape memory element comprises modifying the temperature of the shape memory element.