Copper chelators for treating ocular inflammation

• US 7,754,765 B2
• Filed: 05/30/2003
• Issued: 07/13/2010
• Est. Priority Date: 12/01/2000
• Status: Expired due to Fees

• Current Assignee: Li Ning
• Original Assignee: Radical Vision Therapeutics Inc.
• Inventors: Wang, Xuefeng, Matsubara, Joanne A., Cui, Jing Z.
• Primary Examiner(s): Fay; Zohreh A
• Application Number:
  US10/452,804
• Publication Number:
  US 20030232799A1
• Time in Patent Office: 2,601 Days
• Field of Search: 514/554, 514/674, 514/912
• US Class Current: 514/554
• CPC Class Codes: A61F 2009/00863 Retina
• CPC Class Codes: A61F 9/00821 for coagulation
• CPC Class Codes: A61K 31/132 having two or more amino groups, e.g. spermidine, putrescine

Abstract

In various aspects, the invention provides methods for treating ocular inflammation using copper chelating compounds, such as compounds other than D-penicillamine. In some embodiments, such compounds may be polyamines, such as triethylenetetramine or tetraethylenepentamine. For example, the present invention provides methods for treating inflammation secondary to ocular laser therapy.

Claims

1. A method for treating ocular inflammation in an animal in need of such treatment comprising systemically administering to the animal an effective amount of a polyamine copper chelator having from 4 to 6 amine groups.

2. The method according to claim 1, wherein the animal is a mammal.

3. The method according to claim 1, wherein the animal is a human.

4. The method according to claim 3, wherein the ocular inflammation results from laser eye therapy.

5. The method according to claim 3, wherein the ocular inflammation results from trauma.

6. The method according to claim 3, wherein the ocular inflammation results from exposure to ultraviolet light.

7. The method according to claim 3, wherein the ocular inflammation results from exposure to chemical stimuli.

8. The method according to claim 3, wherein the ocular inflammation results from exposure to a toxin.

9. The method according to claim 3, wherein the ocular inflammation results from a condition selected from the group consisting of allergic conjunctivitis, Reiter'"'"'s disease, scleritis, iridocyclitis, uveitis, Vogt-Koyanagi syndrome, photophthalmia, nongranulomatous inflammation of the uveal tract, granulomatous inflammation of the uveal tract, necrosis of neoplasms, foreign particles lodged in the eye, retinal light toxicity and retinal edema from light exposure.

10. The method according to claim 4, wherein the copper chelator is triethylenetetramine.

11. The method according to claim 5, wherein the copper chelator is triethylenetetramine.

12. The method according to claim 6, wherein the copper chelator is triethylenetetramine.

13. The method according to claim 7, wherein the copper chelator is triethylenetetramine.

14. The method according to claim 8, wherein the copper chelator is triethylenetetramine.

15. The method according to claim 9, wherein the copper chelator is triethylenetetramine.

16. The method according to claim 4, wherein the copper chelator is tetraethylenepentamine.

17. The method according to claim 5, wherein the copper chelator is tetraethylenepentamine.

18. The method according to claim 6, wherein the copper chelator is tetraethylenepentamine.

19. The method according to claim 7, wherein the copper chelator is tetraethylenepentamine.

20. The method according to claim 8, wherein the copper chelator is tetraethylenepentamine.

21. The method according to claim 9, wherein the copper chelator is tetraethylenepentamine.

22. The method according to claim 3, wherein the systemically administering is oral.

23. The method according to claim 3, wherein the systemically administering is parenterally.

24. The method according to claim 3, wherein the polyamine copper chelator having at least 4 amine groups does not have more than 5 amine groups.

25. The method according to claim 24, wherein the ocular inflammation results from at least one of the group consisting of:

laser eye therapy, trauma, exposure to ultraviolet light, exposure to chemical stimuli, and exposure to a toxin.

26. The method according to claim 24, wherein the ocular inflammation results from a condition selected from the group consisting of allergic conjunctivitis, Reiter'"'"'s disease, scleritis, iridocyclitis, uveitis, Vogt-Koyanagi syndrome, photophthalmia, nongranulomatous inflammation of the uveal tract;

granulomatous inflammation of the uveal tract, necrosis of neoplasms, foreign particles lodged in the eye, retinal light toxicity and retinal edema from light exposure.

27. The method according to claim 24, wherein the systemically administering is selected from the group consisting of:

oral and parenterally.