Methods of forming a needle and hub assembly for automatic injectors

• US 7,757,370 B2
• Filed: 04/29/2009
• Issued: 07/20/2010
• Est. Priority Date: 10/10/2000
• Status: Expired due to Fees

• Current Assignee: Meridian Medical Technologies Incorporated
• Original Assignee: Meridian Medical Technologies Incorporated
• Inventors: Griffiths, Steven M.
• Primary Examiner(s): Omgba; Essama
• Application Number:
  US12/431,850
• Publication Number:
  US 20090205744A1
• Time in Patent Office: 447 Days
• Field of Search: 604/240, 604/241, 604/242, 604/243, 294/34, 295/250.1, 297/77, 264/251, 264/254, 264/255
• US Class Current: 29/525.01
• CPC Class Codes: A61M 2005/206 With automatic needle insertion
• CPC Class Codes: A61M 2005/2462 by displacing occluding plugs
• CPC Class Codes: A61M 2005/3132 having flow passages for injection agents at the distal end of the barrel to bypass a sealing stopper after its displacement to this end due to internal pressure increase
• CPC Class Codes: A61M 5/20 Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically A61M5/142 , A61M5/46 take precedence; hypodermic projectiles F42B12/54
• CPC Class Codes: A61M 5/2033 Spring-loaded one-shot injectors with or without automatic needle insertion multishot dosing syringes A61M5/31525, needle insertion only A61M5/3287
• CPC Class Codes: A61M 5/2066 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/2459 upon internal pressure increase, e.g. pierced or burst A61M5/2429 takes precedence
• CPC Class Codes: A61M 5/284 comprising means for injection of two or more media, e.g. by mixing
• CPC Class Codes: A61M 5/286 upon internal pressure increase, e.g. pierced or burst A61M5/283 takes precedence
• CPC Class Codes: A61M 5/3145 Filters incorporated in syringes
• CPC Class Codes: A61M 5/3293 characterised by features of the needle hub
• CPC Class Codes: A61M 5/34 Constructions for connecting the needle , e.g. to syringe nozzle or needle hub connecting catheter tubes to hubs A61M25/0014
• CPC Class Codes: A61M 5/343 Connection of needle cannula to needle hub, or directly to syringe nozzle without a needle hub A61M5/322 takes precedence
• CPC Class Codes: A61M 5/348 snap lock, i.e. upon axial displacement of needle assembly A61M5/344 takes precedence
• CPC Class Codes: Y10T 29/49826 Assembling or joining
• CPC Class Codes: Y10T 29/4984 Retaining clearance for motion between assembled parts
• CPC Class Codes: Y10T 29/49947 by applying separate fastener

Abstract

A needle and hub assembly for automatic injectors includes a cap or skirt that has a forward surface interposed between and reinforced by first and second engaged hub portions. A needle is received in a contiguous channel formed in the two hub portions. Methods of forming the assembly include molding the first hub portion, placing the cap over the first hub portion, inserting the needle into the channel in the first hub portion, and then overmolding or otherwise forming the second hub portion on the exterior of the first hub portion and cap such that the second hub portion engages the first hub portion. An assembly created by this “two-shot” process can be used to seal a relatively large opening in a medicament cartridge and to support the needle more effectively than a conventional assembly.

Claims

1. A method of forming a needle and hub assembly for automatic injectors, the method comprising:

forming a first hub portion having a forward section and a flange section, the forward section defining a needle-receiving channel;

inserting a needle in the needle-receiving channel;

forming a cap having an engaging portion and a needle supporting portion, the engaging portion configured to engage a medicament cartridge of an automatic injector, the needle-supporting portion having a wall that includes an opening therein, the wall defining interior and exterior surfaces opposite each other;

arranging the cap over the needle and the first hub portion such that;

the needle and the forward section of the first hub portion extend through the opening in the wall of the cap, and

the flange section of the first hub portion extends along and abuts the interior surface of the wall of the cap; and

forming a second hub portion over the needle and first hub portion, the second hub portion having a forward tapering section and a plurality of radially-extending structures, the forward tapering section defining a needle-receiving channel in alignment with the needle-receiving channel of the first hub portion, the forward tapering section of the second hub portion engaging the forward section of the first hub portion, and the radially-extending structures abutting the exterior surface of the wall of the cap and extending outwardly across the wall to form a contiguous structure of the second hub portion that extends along the interior and exterior surfaces of the wall, the wall, and the first hub portion.

2. A method of assembling an automatic injector comprising:

providing an outer housing of the automatic injector;

providing an actuation assembly in the outer housing;

filling a medicament cartridge with one or more medicament components, the medicament cartridge having an open end;

attaching the needle and hub assembly formed by the method of claim 1 over the open end of the medicament cartridge; and

inserting the medicament cartridge with attached needle and hub assembly in the outer housing, the medicament cartridge in communication with the actuation assembly.

3. The method of claim 1 wherein forming the cap comprises extruding a metal to form the cap.

4. The method of claim 1 wherein forming the cap having an engaging portion comprises forming a cylindrically-shaped cap of sufficient diameter to fit over the outside end of a medicament cartridge.

5. The method of claim 1 wherein forming the cap having an engaging portion comprises forming hemispherical interior protrusions on the engaging portion configured to be press fit over a corresponding groove on an exterior surface of a medicament cartridge.

6. The method of claim 1 wherein forming the first hub portion and the second hub portion comprises injection molding the first and second hub portions.

7. The method of claim 1 wherein forming the first hub portion and the second hub portion comprises forming the first and second hub portions with a medical grade polymer.

8. The method of claim 1 wherein forming the first hub portion and the second hub portion comprises forming the first and second hub portions with thermally compatible materials.

9. The method of claim 1 wherein forming the second hub portion comprises overmolding the second hub portion onto the needle and first hub portion.

10. The method of claim 1 wherein forming the second hub portion comprises permanently joining the forward tapering section of the second hub portion to the forward section of the first hub portion.

11. A method of forming a needle and hub assembly for automatic injectors, the method comprising:

forming a first hub portion having a forward section and a flange section, the forward section defining a needle-receiving channel;

inserting a needle in the needle-receiving channel;

forming a cap having an engaging portion and a needle supporting portion, the engaging portion configured to engage a medicament cartridge of an automatic injector, the needle-supporting portion having a wall that includes an opening therein, the wall defining interior and exterior surfaces opposite each other;

arranging the cap over the needle and the first hub portion such that;

the needle and the forward section of the first hub portion extend through the opening in the wall of the cap, and

the flange section of the first hub portion extends along and abuts the interior surface of the wall of the cap; and

forming a second hub portion over the needle and first hub portion, the second hub portion having a forward tapering section and a plurality of radially-extending structures, the forward tapering section defining a needle-receiving channel in alignment with the needle-receiving channel of the first hub portion, the forward tapering section of the second hub portion engaging the forward section of the first hub portion causing a portion of the first hub portion to melt and fuse with the second hub portion, the radially-extending structures abutting the exterior surface of the wall of the cap and extending outwardly across the wall to form a contiguous structure of the second hub portion, the wall, and the first hub portion in a direction parallel to the aligned needle-receiving channels of the first and second hub portions.

12. A method of forming a needle and hub assembly for automatic injectors, the method comprising:

forming a first hub portion having a forward section and a flange section, the forward section defining a needle-receiving channel having a stop formed therein to limit the insertion depth of a needle inserted therein;

inserting a needle in the needle-receiving channel until the needle abuts the stop;

forming a cap having an engaging portion and a needle supporting portion, the engaging portion configured to engage a medicament cartridge of an automatic injector, the needle-supporting portion having a wall that includes an opening therein, the wall defining interior and exterior surfaces opposite each other;

arranging the cap over the needle and the first hub portion such that;

the needle and the forward section of the first hub portion extend through the opening in the wall of the cap, and

the flange section of the first hub portion extends along and abuts the interior surface of the wall of the cap; and

forming a second hub portion over the needle and first hub portion, the second hub portion having a forward tapering section and a plurality of radially-extending structures, the forward tapering section defining a needle-receiving channel in alignment with the needle-receiving channel of the first hub portion, the forward tapering section of the second hub portion engaging the forward section of the first hub portion, and the radially-extending structures abutting the exterior surface of the wall of the cap and extending outwardly across the wall.

13. A method of assembling an automatic injector comprising:

providing an outer housing of the automatic injector;

providing an actuation assembly in the outer housing;

filling a medicament cartridge with one or more medicament components, the medicament cartridge having an open end;

attaching the needle and hub assembly formed by the method of claim 12 over the open end of the medicament cartridge; and

inserting the medicament cartridge with attached needle and hub assembly in the outer housing, the medicament cartridge in communication with the actuation assembly.

14. The method of claim 12 wherein forming the cap comprises forming the cap with a plastic material having sufficient rigidity.

15. The method of claim 12 wherein forming the first hub portion comprises forming a first hub portion having a rearward section defining a chamber in communication with the needle-receiving channel of the first hub portion.

16. The method of claim 15 further comprising covering a rearward opening of the chamber with a filter.

17. The method of claim 12 wherein forming the second hub portion having a forward tapering section defining a needle-receiving channel comprises forming a second hub portion having a forward tapering section defining a needle-receiving channel that is longer than the needle-receiving channel of the first hub portion.

18. The method of claim 12 wherein forming the first hub portion and the second hub portion comprises forming the first and second hub portions with the same material.

19. The method of claim 12, further comprising after arranging the cap and before forming the second hub portion, moving the assembly of the needle, first hub portion, and cap to a second mold having cavities defining the second hub portion.

20. The method of claim 12 wherein forming the second hub portion comprises forming the second hub portion such that a portion of the first hub portion melts to create a melt zone at which the second hub portion and the first hub portion form a single piece.