Tear film measurement

• US 7,758,190 B2
• Filed: 06/20/2007
• Issued: 07/20/2010
• Est. Priority Date: 06/20/2007
• Status: Active Grant

• Current Assignee: TearScience Inc. (Johnson & Johnson)
• Original Assignee: TearScience Inc. (Johnson & Johnson)
• Inventors: Korb, Donald R., Gravely, Benjamin T.
• Primary Examiner(s): Dang; Hung X
• Application Number:
  US11/820,664
• Publication Number:
  US 20080316499A1
• Time in Patent Office: 1,126 Days
• Field of Search: 351/221, 351/246, 351/205, 351/200, 356/503, 600/476
• US Class Current: 351/221
• CPC Class Codes: A61B 3/101 for examining the tear film
• CPC Class Codes: G01B 11/0675 using interferometry

Abstract

The invention comprises an apparatus for measuring the relative thickness of the lipid layer component of the precorneal tear film on the surface of an eye after distribution of the lipid layer subsequent to blinking is disclosed. An illuminator directs light to the lipid layer of a patient'"'"'s eye. The illuminator is a broad spectrum light source covering the visible region and is a lambertion light emitter such that the light source is specularly reflected from the lipid layer and undergoes constructive and destructive interference in the lipid layer. A collector collects and focuses the specularly reflected light such that the interference patterns on the tear film lipid layer are observable. The collector also produces an output signal representative of the specularly reflected light which is suitable for further analysis, such as projection on to a high resolution video monitor or analysis by or storage in a computer. In order to facilitate ease of measurement, the patient'"'"'s head may be positioned on an observation platform when the illuminator directs light to the lipid layer of the patient'"'"'s eye.

Claims

1. An apparatus for measuring the thickness of the lipid layer on the surface of a patient'"'"'s eye after distribution of the lipid layer subsequent to blinking comprising:

an illuminator that directs light to the lipid layer of a patient'"'"'s eye, the illuminator comprising a broad spectrum light source in the visible region being a lambertian emitter such that the rays from the light source are specularly reflected from the lipid layer and undergo constructive and destructive interference in the lipid layer, wherein said illuminator further includes a plurality of spaced apart light emitting diodes adapted to emit light in the visible region;

an imaging device for observing the specularly reflected light such that the interference patterns on the tear film lipid layer are observable; and

a diffuser for diffusing the light emitted by the respective light emitting diodes positioned between said light emitting diodes and the surface of the eye, wherein the diffuser is arcuate such that the light rays emitted therefrom strike the surface of the eye such that Snell'"'"'s law is satisfied with respect to the acceptance angle of said imaging device so as to produce an observable area of interference on the eye.

2. The apparatus according to claim 1 wherein said illuminator comprises an arcuate emitter and wherein the surface of said lambertian emitter is substantially parallel to the surface of the eye.

3. The apparatus according to claim 1 wherein said imaging device comprises a hole defining an opening in said illuminator.

4. The apparatus according to claim 3 wherein said opening in said illuminator allows for observation of the specularly reflected light from behind said illuminator.

5. The apparatus according to claim 3 further including a collector for collecting and focusing the specularly reflected light and for generating an output signal representative thereof operatively associated with said opening.

6. The apparatus according to claim 5 further including a recording device for recording the output signal representative of the specularly reflected light.

7. The apparatus according to claim 6 wherein said recording device records in real time.

8. The apparatus according to claim 6 wherein said recording device is selected from the group of recording devices consisting of computer memory, video cassette recording devices, analog recording devices and digital recording devices.

9. The apparatus according to claim 5 wherein said collector comprises a camera lens system.

10. The apparatus according to claim 1 wherein said specularly reflected light is observed when the patient'"'"'s head is positioned on an observation platform.

11. The apparatus according to claim 1 wherein the light rays that generate the observable area of interference are substantially normal to the surface of the eye.

12. The apparatus according to claim 1 wherein said illuminator has a total radiated power of less than 1 W.

13. An apparatus for measuring the thickness of the lipid layer on the surface of an eye after distribution of the lipid layer subsequent to blinking comprising:

an illuminator that directs light to the lipid layer of a patient'"'"'s eye, the illuminator being a broad spectrum light source in the visible region and being a lambertian emitter such that the light source is specularly reflected from the lipid layer and undergoes constructive and destructive interference in the lipid layer and wherein the total light emitted from the surface of the illuminator is less that 10 μ

W/mm², wherein said illuminator further includes a plurality of spaced apart light emitting diodes adapted to emit light in the visible region;

an imaging device for observing the specularly reflected light such that the interference patterns on the tear film lipid layer are observable; and

a diffuser for diffusing the light emitted by the respective light emitting diodes positioned between said light emitting diodes and the surface of the eye, wherein the diffuser is arcuate such that the light rays emitted from the lambertian emitter strike the surface of the eye such that Snell'"'"'s law is satisfied with respect to the acceptance angle of said imaging device so as to produce an observable area of interference on the eye.

14. The apparatus according to claim 13 wherein said imaging device comprises a hole defining an opening in the illuminator.

15. The apparatus according to claim 14 wherein said opening in said illuminator allows for observation of the specularly reflected light from behind said illuminator.

16. The apparatus according to claim 14 further including a collector for collecting and focusing the specularly reflected light and for generating an output signal representative thereof operatively associated with said opening.

17. The apparatus according to claim 16 further including a recording device for recording the output signal representative of the specularly reflected light.

18. The apparatus according to claim 17 wherein said recording device records in real time.

19. The apparatus according to claim 16 wherein said collector comprises a camera lens system.

20. The apparatus according to claim 17 wherein said recording device is selected from the group of recording devices consisting of computer memory, video cassette recording devices, analog recording devices and digital recording devices.

21. The apparatus according to claim 16 wherein said arcuate emitter is constructed and arranged such that the light rays emitted therefrom strike the surface of the eye such that Snell'"'"'s law is satisfied with respect to the acceptance angle of said collector for collecting the specularly reflected light to produce an observable area of interference on the eye.

22. The apparatus according to claim 21 wherein said illuminator has a total radiated power of less than 1 W.

23. The apparatus according to claim 21 wherein the light rays that generate the observable area of interference are essentially normal to the surface of the eye.

24. The apparatus according to claim 13 wherein the specularly reflected light is observed when the patient'"'"'s head is positioned on an observation platform.

25. An apparatus for measuring the thickness of the lipid layer on the surface of a patient'"'"'s eye after distribution of the lipid layer subsequent to blinking comprising:

an illuminator that directs light to the lipid layer of a patient'"'"'s eye, the illuminator comprising a broad spectrum light source in the visible region and being a uniform illumination lambertian emitter such that the light source is specularly reflected from the lipid layer and undergoes constructive and destructive interference in the lipid layer wherein said illuminator illuminates the patient'"'"'s face, but wherein only an area below the pupil satisfies Snell'"'"'s law, wherein said illuminator further includes a plurality of spaced apart light emitting diodes adapted to emit light in the visible region;

an imaging device for observing the specularly reflected light such that the interference patterns on the tear film lipid layer are observable in the area below the pupil with respect to the acceptance angle of said imaging device so as to produce an observable area of interference on the eye below the pupil; and

a diffuser for diffusing the light emitted by the respective light emitting diodes positioned between said light emitting diodes and the surface of the eye, wherein the diffuser is arcuate such that the light rays emitted from the lambertian emitter strike the surface of the eye such that Snell'"'"'s law is satisfied with respect to the acceptance angle of said imaging device so as to produce an observable area of interference on the eye.

26. The apparatus according to claim 25 further including a collector for collecting and focusing the specularly reflected light such that the interference patterns on the tear film lipid layer are observable.

27. The apparatus according to claim 26 wherein said collector for collecting and for focusing the specularly reflected light generates an output signal representative thereof.

28. The apparatus according to claim 25 wherein said illuminator illuminates an area of the patient'"'"'s eye and wherein the area having viewable interference fringes is located below the pupil.

29. The apparatus according to claim 28 wherein the area having viewable interference fringes is an area of at least 12.5 mm².

30. The apparatus according to claim 28 wherein the specularly reflected light is observed when the patient'"'"'s head is positioned on an observation platform.

31. The apparatus according to claim 25 wherein said illuminator has a total illumination intensity of less than that which would induce reflex tearing or cause a proprioceptive response to occur.

32. The apparatus according to claim 31 wherein said illuminator has a total illumination intensity of between about 1 μ

W/mm² and 15 μ

W/mm² at the surface of the illuminator.

33. The apparatus according to claim 25 further including a recording device for recording the observable area of interference of the specularly reflected light.

34. The apparatus according to claim 33 wherein said recording device records in real time.

35. The apparatus according to claim 33 wherein said recording device is selected from the group of recording devices consisting of computer memory, video cassette recording devices, analog recording devices and digital recording devices.

36. The apparatus according to claim 25 where said diffuser is arcuate such that the light rays emitted from the lambertian emitter strike the surface of the eye tangential thereto.

37. An apparatus for measuring the thickness of the lipid layer on the surface of an eye after distribution of the lipid layer subsequent to blinking comprising:

an illuminator that directs light to the lipid layer of a patient'"'"'s eye, the illuminator being a broad spectrum light source in the visible region and being a uniform illumination lambertian emitter such that the light source is specularly reflected from the lipid layer and undergoes constructive and destructive interference in the lipid layer and wherein the light emitted from the illuminator travels directly to the lipid layer without reflection and strikes the lipid layer, wherein said illuminator further includes a plurality of spaced apart light emitting diodes adapted to emit light in the visible region;

an imaging device for collecting the specularly reflected light and for focusing the specularly reflected light such that the interference patterns on the tear film lipid layer are observable; and

a diffuser for diffusing the light emitted by the respective light emitting diodes positioned between said light emitting diodes and the surface of the eye, wherein the diffuser is arcuate such that the light rays emitted from the lambertian emitter strike the surface of the eye such that Snell'"'"'s law is satisfied with respect to the acceptance angle of said imaging device so as to produce an observable area of interference on the eye.

38. The apparatus according to claim 37 further including a collector for collecting and focusing the specularly reflected light such that the interference patterns on the tear film lipid layer are observable.

39. The apparatus according to claim 38 wherein said collector for collecting and for focusing the specularly reflected light generates an output signal representative thereof.

40. The apparatus according to claim 37 wherein said illuminator illuminates an area of the patient'"'"'s eye and wherein the area having viewable interference fringes is located below the pupil.

41. The apparatus according to claim 40 wherein the specularly reflected light is observed when the patient'"'"'s head is positioned on an observation platform.

42. The apparatus according to claim 37 wherein the area having viewable interference fringes is an area of at least 12.5 mm².

43. The apparatus according to claim 37 wherein said illuminator has a total illumination intensity of less than that which would induce reflex tearing or cause a proprioceptive response to occur.

44. The apparatus according to claim 37 wherein said illuminator has a total illumination intensity of between about 1 μ

W/mm² and 15 μ

W/mm² at the surface of the illuminator.

45. The apparatus according to claim 37 wherein said illuminator has a total radiated power of less than about 1 W.

46. The apparatus according to claim 37 further including a recording device for recording the observable area of interference of the specularly reflected light.

47. The apparatus according to claim 46 wherein said recording device records in real time.

48. The apparatus according to claim 46 wherein said recording device is selected from the group of recording devices selected from the group consisting of computer memory, video cassette recording devices and digital recording devices.

49. The apparatus according to claim 37 where the diffuser is arcuate such that the light rays emitted from the lambertian emitter strike the surface of the eye tangential thereto.

50. An apparatus for measuring the thickness of the lipid layer on the surface of a patient'"'"'s eye after distribution of the lipid layer subsequent to blinking comprising:

an illuminator that directs light to the lipid layer of a patient'"'"'s eye, the illuminator comprising a broad spectrum light source in the visible region being a lambertian emitter such that the rays from the light source are specularly reflected from the lipid layer and undergo constructive and destructive interference in the lipid layer, wherein said illuminator further includes a plurality of spaced apart light emitting diodes adapted to emit light in the visible region; and

an imaging device for observing the specularly reflected light such that the interference patterns on the tear film lipid layer are observable.

51. The apparatus according to claim 50 wherein said illuminator comprises an arcuate emitter and wherein the surface of said lambertian emitter is substantially parallel to the surface of the eye.

52. The apparatus according to claim 51 wherein said arcuate emitter is constructed and arranged such that the light rays emitted therefrom strike the surface of the eye such that Snell'"'"'s law is satisfied with respect to the acceptance angle of said imaging device and produces an observable area of interference on the surface of the eye.

53. The apparatus according to claim 52 wherein the light rays that generate the observable area of interference are substantially normal to the surface of the eye.

54. The apparatus according to claim 50 wherein said imaging device comprises a hole defining an opening in said illuminator.

55. The apparatus according to claim 54 further including a collector for collecting and focusing the specularly reflected light and for generating an output signal representative thereof operatively associated with said opening.

56. The apparatus according to claim 55 further including a recording device for recording the output signal representative of the specularly reflected light.

57. An apparatus for measuring the thickness of the lipid layer on the surface of an eye after distribution of the lipid layer subsequent to blinking comprising:

an illuminator that directs light to the lipid layer of a patient'"'"'s eye, the illuminator being a broad spectrum light source in the visible region and being a lambertian emitter such that the light source is specularly reflected from the lipid layer and undergoes constructive and destructive interference in the lipid layer and wherein the total light emitted from the surface of the illuminator is less that 10 μ

W/mm², wherein said illuminator further includes a plurality of spaced apart light emitting diodes adapted to emit light in the visible region; and

an imaging device for observing the specularly reflected light such that the interference patterns on the tear film lipid layer are observable.

58. The apparatus according to claim 57 wherein said illuminator further includes an arcuate emitter and wherein the surface of said emitter is substantially parallel to the surface of the eye.

59. The apparatus according to claim 58 wherein said imaging device comprises a hole defining an opening in the illuminator.

60. The apparatus according to claim 59 further including a collector for collecting and focusing the specularly reflected light and for generating an output signal representative thereof operatively associated with said opening.

61. The apparatus according to claim 60 further including a recording device for recording the output signal representative of the specularly reflected light.

62. The apparatus according to claim 60 further including a camera lens system for collecting the specularly reflected light and for focusing the specularly reflected light to generate an output signal representative thereof.

63. The apparatus according to claim 60 wherein the light rays that generate the observable area of interference are essentially normal to the surface of the eye.

64. An apparatus for measuring the thickness of the lipid layer on the surface of a patient'"'"'s eye after distribution of the lipid layer subsequent to blinking comprising:

an illuminator that directs light to the lipid layer of a patient'"'"'s eye, the illuminator comprising a broad spectrum light source in the visible region and being a uniform illumination lambertian emitter such that the light source is specularly reflected from the lipid layer and undergoes constructive and destructive interference in the lipid layer, wherein said illuminator illuminates the patient'"'"'s face, but wherein only an area below the pupil satisfies Snell'"'"'s law, wherein said illuminator further includes a plurality of spaced apart light emitting diodes adapted to emit light in the visible region; and

an imaging device for observing the specularly reflected light such that the interference patterns on the tear film lipid layer are observable in the area below the pupil with respect to the acceptance angle of said imaging device so as to produce an observable area of interference on the eye below the pupil.

65. The apparatus according to claim 64 further including a collector for collecting and focusing the specularly reflected light such that the interference patterns on the tear film lipid layer are observable.

66. The apparatus according to claim 65 wherein said collector for collecting and for focusing the specularly reflected light generates an output signal representative thereof.

67. The apparatus according to claim 64 wherein said illuminator illuminates an area of the patient'"'"'s eye and wherein the area having viewable interference fringes is located below the pupil.

68. The apparatus according to claim 67 wherein the area having viewable interference fringes is an area of at least 12.5 mm².

69. The apparatus according to claim 64 wherein said illuminator has a total illumination intensity of between about 1 μ

W/mm² and 15 μ

W/mm² at the surface of the illuminator.

70. The apparatus according to claim 64 wherein said illuminator comprises an array of light emitting diodes and a diffuser positioned between the respective diode array and the lipid layer of the tear film.

71. The apparatus according to claim 70 where said diffuser is arcuate such that the light rays emitted from the lambertian emitter strike the surface of the eye tangential thereto.

72. An apparatus for measuring the thickness of the lipid layer on the surface of an eye after distribution of the lipid layer subsequent to blinking comprising:

an illuminator that directs light to the lipid layer of a patient'"'"'s eye, the illuminator being a broad spectrum light source in the visible region and being a uniform illumination lambertian emitter such that the light source is specularly reflected from the lipid layer and undergoes constructive and destructive interference in the lipid layer and wherein the light emitted from the illuminator travels directly to the lipid layer without reflection and strikes the lipid layer, wherein said illuminator further includes a plurality of spaced apart light emitting diodes adapted to emit light in the visible region; and

an imaging device for collecting the specularly reflected light and for focusing the specularly reflected light such that the interference patterns on the tear film lipid layer are observable.

73. The apparatus according to claim 72 further including a collector for collecting and focusing the specularly reflected light such that the interference patterns on the tear film lipid layer are observable.

74. The apparatus according to claim 73 wherein said illuminator illuminates an area of the patient'"'"'s eye and wherein the area having viewable interference fringes is located below the pupil.

75. The apparatus according to claim 73 wherein said collector for collecting and for focusing the specularly reflected light generates an output signal representative thereof.

76. The apparatus according to claim 72 wherein the area having viewable interference fringes is an area of at least 12.5 mm².

77. The apparatus according to claim 72 further including a diffuser positioned between said respective diode array and the lipid layer of the tear film.

78. The apparatus according to claim 77 where the diffuser is arcuate such that the light rays emitted from the lambertian emitter strike the surface of the eye tangential thereto.