Method and apparatus for viewing through blood

• US 7,758,499 B2
• Filed: 11/16/2006
• Issued: 07/20/2010
• Est. Priority Date: 08/10/2001
• Status: Expired due to Fees

• Current Assignee: C2Cure Inc.
• Original Assignee: C2Cure Inc.
• Inventors: Adler, Doron
• Primary Examiner(s): Leubecker; John P
• Application Number:
  US11/560,796
• Publication Number:
  US 20070100241A1
• Time in Patent Office: 1,342 Days
• Field of Search: 600/109, 600/153, 600/156, 600/158
• US Class Current: 600/158
• CPC Class Codes: A61B 1/00082 Balloons
• CPC Class Codes: A61B 1/00091 Nozzles
• CPC Class Codes: A61B 1/00193 adapted for stereoscopic vision
• CPC Class Codes: A61B 1/015 Control of fluid supply or evacuation
• CPC Class Codes: A61B 1/05 characterised by the image sensor, e.g. camera, being in the distal end portion
• CPC Class Codes: A61B 1/0638 providing two or more wavelengths
• CPC Class Codes: A61B 1/3137 for examination of the interior of blood vessels
• CPC Class Codes: A61B 5/0084 for introduction into the body, e.g. by catheters A61B5/1459 takes precedence
• CPC Class Codes: A61B 5/02007 Evaluating blood vessel condition, e.g. elasticity, compliance
• CPC Class Codes: A61B 5/0275 using tracers, e.g. dye dilution
• CPC Class Codes: Y10S 977/869 Optical microscope
• CPC Class Codes: Y10S 977/876 Nanotube tip

Abstract

A method, apparatus, and system for viewing through blood in situ including a flexible catheter for insertion into a blood vessel, an optical assembly positioned at the distal end of the catheter, a working channel, and a control unit for regulating the opacity level of blood in the blood vessel around the distal end of the catheter and controllably injecting quantities of fluid into the blood vessel in the vicinity of the optical assembly. A local controller located at the distal end of the catheter may control functions of the optical assembly while coordinating signals and power with the control unit. Some possible embodiments, may include an inflatable stent balloon.

Claims

1. An invasive imaging control apparatus comprising:

i. a flexible catheter with a proximal end and a distal end, said distal end being shaped for insertion into a blood vessel along a guide wire thereby to reach remote places in the vasculature or other organs;

ii. an optical assembly positioned at the distal end of said catheter;

iii. at least one working channel running from the proximal to the distal end of said catheter;

iv. a control unit, that is not inserted into the blood vessel with the catheter, for regulating the opacity level of blood in said blood vessel around said distal end of said catheter, controllably injecting quantities of fluid into said blood vessel in the vicinity of said optical assembly, thereby enhancing visibility;

v. a local controller located at the distal end of the catheter for controlling data flow to and from an optical head at the distal end portion of the catheter, the optical head comprising an image sensor and at least one of an illumination source, a light sensor, or a shutter, and wherein the local controller is configured to control one or more functions of the optical head while coordinating signals and power with the control unit and the functions of the optical head being selected from the group consisting of (1) commanding the illumination source, (2) accepting signals from the light sensor, (3) accepting signals from the image sensor, and (4) commanding the shutter; and

wherein said optical head comprises a light sensor operable to sense at least one wavelength taken from within a range from visible light to infra-red light.

2. A method for viewing through blood in situ comprising:

placing at least a distal end portion of a medical instrument into a blood vessel;

injecting a controlled amount of fluid into blood in the immediate region in front of an optical assembly included on the distal end portion of the medical instrument presented in the blood vessel;

controlling data flow to and from an optical head at the distal end portion of the medical instrument, the optical head comprising a local controller which is included in the distal end portion of the medical instrument, the optical head comprising an image sensor and at least one of an illumination source, a light sensor, or a shutter, and wherein the local controller serves to control one or more functions of the optical head while coordinating signals and power with a central control unit that is not inserted into the blood vessel, and the controlled functions of the optical head being selected from the group consisting of (1) commanding the illumination source, (2) accepting signals from the light sensor, (3) accepting signals from the image sensor, and (4) commanding the shutter,

temporarily changing the amount of fluid injected in front of the optical assembly based on the data flow received from the optical head; and

wherein said fluid is used to change the optical characteristics of blood in situ to facilitate imaging through said blood, said fluid being a hypoosmolar fluid.

3. The method of claim 2 wherein the hypoosmolar fluid is 0.45% saline.

4. The method of claim 2 wherein the hypoosmolar fluid is ⅙

saline.

5. A method for viewing through blood in situ comprising:

placing at least a distal end portion of a medical instrument into a blood vessel;

injecting a controlled amount of fluid into blood in the immediate region in front of an optical assembly included on the distal end portion of the medical instrument presented in the blood vessel;

controlling data flow to and from an optical head at the distal end portion of the medical instrument, the optical head comprising a local controller which is included in the distal end portion of the medical instrument, the optical head comprising an image sensor and at least one of an illumination source, a light sensor, or a shutter, and wherein the local controller serves to control one or more functions of the optical head while coordinating signals and power with a central control unit that is not inserted into the blood vessel, and the controlled functions of the optical head being selected from the group consisting of (1) commanding the illumination source, (2) accepting signals from the light sensor, (3) accepting signals from the image sensor, and (4) commanding the shutter;

temporarily changing the amount of fluid injected in front of the optical assembly based on the data flow received from the optical head; and

further comprising running a post processing algorithm that starts with formation of a training image and that allows generation of a final image based on communications of the local controller and the central control unit.

6. The method of claim 5 wherein the post processing algorithm reconstructs a displayed image based on a training sequence and a real time image.

7. The method of claim 5 wherein the post processing algorithm generates the final image utilizing the steps of contrast and intensity enhancement.

8. An invasive imaging control apparatus comprising:

i. a flexible catheter with a proximal end and a distal end, said distal end being shaped for insertion into a blood vessel along a guide wire thereby to reach remote places in the vasculature or other organs;

ii. an optical assembly positioned at the distal end of said catheter;

iii. at least one working channel running from the proximal to the distal end of said catheter;

iv. a control unit, that is not inserted into the blood vessel with the catheter, for regulating the opacity level of blood in said blood vessel around said distal end of said catheter, controllably injecting quantities of fluid into said blood vessel in the vicinity of said optical assembly, thereby enhancing visibility;

v. a local controller located at the distal end of the catheter for controlling data flow to and from an optical head at the distal end portion of the catheter, the optical head comprising an image sensor and at least one of an illumination source, a light sensor, or a shutter, and wherein the local controller is configured to control one or more functions of the optical head while coordinating signals and power with the control unit and the functions of the optical head being selected from the group consisting of (1) commanding the illumination source, (2) accepting signals from the light sensor, (3) accepting signals from the image sensor, and (4) commanding the shutter; and

wherein the optical head includes a light source and the local controller controls the light source.

9. An invasive imaging control apparatus comprising:

i. a flexible catheter with a proximal end and a distal end, said distal end being shaped for insertion into a blood vessel along a guide wire thereby to reach remote places in the vasculature or other organs;

ii. an optical assembly positioned at the distal end of said catheter;

iii. at least one working channel running from the proximal to the distal end of said catheter;

iv. a control unit, that is not inserted into the blood vessel with the catheter, for regulating the opacity level of blood in said blood vessel around said distal end of said catheter, controllably injecting quantities of fluid into said blood vessel in the vicinity of said optical assembly, thereby enhancing visibility;

v. a local controller located at the distal end of the catheter for controlling data flow to and from an optical head at the distal end portion of the catheter, the optical head comprising an image sensor and at least one of an illumination source, a light sensor, or a shutter, and wherein the local controller is configured to control one or more functions of the optical head while coordinating signals and power with the control unit and the functions of the optical head being selected from the group consisting of (1) commanding the illumination source, (2) accepting signals from the light sensor, (3) accepting signals from the image sensor, and (4) commanding the shutter; and

wherein the optical head includes a pressure sensor and the local controller receives local feedback from the pressure sensor.

10. An invasive imaging control apparatus comprising:

i. a flexible catheter with a proximal end and a distal end, said distal end being shaped for insertion into a blood vessel along a guide wire thereby to reach remote places in the vasculature or other organs;

ii. an optical assembly positioned at the distal end of said catheter;

iii. at least one working channel running from the proximal to the distal end of said catheter;

iv. a control unit, that is not inserted into the blood vessel with the catheter, for regulating the opacity level of blood in said blood vessel around said distal end of said catheter, controllably injecting quantities of fluid into said blood vessel in the vicinity of said optical assembly, thereby enhancing visibility;

v. a local controller located at the distal end of the catheter for controlling data flow to and from an optical head at the distal end portion of the catheter, the optical head comprising an image sensor and at least one of an illumination source, a light sensor, or a shutter, and wherein the local controller is configured to control one or more functions of the optical head while coordinating signals and power with the control unit and the functions of the optical head being selected from the group consisting of (1) commanding the illumination source, (2) accepting signals from the light sensor, (3) accepting signals from the image sensor, and (4) commanding the shutter; and

wherein the optical head includes a light sensor and the local controller receives local feedback from the light sensor.

11. A diagnostic and operative system for use in intra-vascular procedures, comprising:

a flexible catheter with a proximal end and a distal end, the distal end being shaped for insertion into a blood vessel along a guide wire thereby to reach remote places in the vasculature or other organs;

a viewing apparatus positioned at the distal end of the catheter and comprising an image sensor, an optical assembly, and a light source;

at least one working channel running from the proximal to the distal end of the catheter for injecting a controlled amount of fluid into blood in the immediate region in front of the optical assembly;

an inflatable stent balloon at the distal end of the catheter; and

the optical assembly located distally to the stent balloon and within a second balloon so that the injected fluid inflates the second balloon to remove red blood cells from the field of view of the viewing apparatus and to reduce the scattering of light.