Methods and apparatus for non-invasive determination of patient's blood conditions
First Claim
1. A non-invasive method for determination of blood clotting and blood circulation related parameters of a mammal, the method comprising:
- (i) non-invasively inducing at least two stimuli ST in a blood containing medium in the mammal for a preset period of time tST, said at least two stimuli being selected to cause at least one of the following to occur;
(a) inducing at least two of three Virchow'"'"'s triad elements including an abnormality of blood flow, an abnormality of blood constituents, and an abnormality of the blood vessel wall, and (b) inducing a change in red blood cell (RBC) aggregation or local blood viscosity;
(ii) performing non-invasive measurements at a measurement location in the blood containing medium in the mammal by applying an external field thereto for a preset time period tm, detecting a response of the measurement location to the applied field, and generating measured data indicative thereof; and
(iii) processing, with a processor, at least a portion of the measured data and processing stimuli related data so as to determine an output data indicative of a relation between a time function of said at least two stimuli ST(t) and a time function of the measured data OR(t), said relation being a predetermined mathematical manipulation between the time function of said at least two stimuli ST(t) and the time function of the measured data OR(t), said output data being indicative of at least one blood circulation and blood clotting related parameter of the mammal.
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Accused Products
Abstract
A method and apparatus are presented for non-invasive determination of blood clotting related and blood circulation related parameters of a mammal. At least one stimulus ST is non-invasively induced in a blood containing medium in the mammal for a preset period of time tST. This at least one stimulus is selected to cause at least one of the following to occur: (a) inducing at least two of three Virchow'"'"'s triad elements including abnormalities of blood flow; abnormalities of blood constituents and abnormalities of the blood vessel wall, and (b) inducing a change in red blood cell (RBC) aggregation or local blood viscosity. Measurements are non-invasively performed at a measurement location in the mammal by applying an external field thereto for a preset time period tm, a response of the measurement location to the applied field is detected, and measured data indicative thereof generated. At least a portion of the measured data and stimulus related data are processed so as to determine a relation between a time function of the at least one stimulus ST(t) and a time function of the measured data OR(t). This relation is indicative of at least one blood circulation and blood coagulation related parameter of the mammal.
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Citations
31 Claims
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1. A non-invasive method for determination of blood clotting and blood circulation related parameters of a mammal, the method comprising:
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(i) non-invasively inducing at least two stimuli ST in a blood containing medium in the mammal for a preset period of time tST, said at least two stimuli being selected to cause at least one of the following to occur;
(a) inducing at least two of three Virchow'"'"'s triad elements including an abnormality of blood flow, an abnormality of blood constituents, and an abnormality of the blood vessel wall, and (b) inducing a change in red blood cell (RBC) aggregation or local blood viscosity;(ii) performing non-invasive measurements at a measurement location in the blood containing medium in the mammal by applying an external field thereto for a preset time period tm, detecting a response of the measurement location to the applied field, and generating measured data indicative thereof; and (iii) processing, with a processor, at least a portion of the measured data and processing stimuli related data so as to determine an output data indicative of a relation between a time function of said at least two stimuli ST(t) and a time function of the measured data OR(t), said relation being a predetermined mathematical manipulation between the time function of said at least two stimuli ST(t) and the time function of the measured data OR(t), said output data being indicative of at least one blood circulation and blood clotting related parameter of the mammal. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
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21. An apparatus for use in non-invasive determination of blood clotting related and blood circulation related parameters in a mammal, the apparatus comprising:
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(a) a measurement unit configured and operable for applying an external field to a measurement location in a blood containing medium of the mammal, detecting a response from the measurement location to the applied field, and generating measured data indicative thereof; (b) a stimulus inducing device configured and operable to induce at least two stimuli in the blood containing medium in the mammal, said at least two stimuli being of a kind causing at least one of the following to occur;
(i) inducing at least two of three Virchow'"'"'s triad elements in the medium including an abnormality of blood flow;
an abnormality of blood constituents, and an abnormality of the blood vessel wall; and
(ii) inducing a change in the RBC aggregation;(c) a control unit configured for selectively operating said stimulus inducing device to maintain each of said at least two stimuli for a preset period of time tST, for operating the measurement unit to perform measurements and generate the measured, said control unit being preprogrammed to process and analyze the measured data to determine a time function of at least a portion of the measured data and a time function of said at least two stimuli and determine a relation being a predetermined mathematical manipulation between the time variations of said at least two stimuli and the time function of the response, at least portion of the measured data, said mathematical manipulation being indicative of the blood clotting related and blood circulation related parameters in the mammal. - View Dependent Claims (22, 23, 24, 25, 26, 27, 28, 29, 30, 31)
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Specification