Hemofiltration systems, methods and devices for treatment of chronic and acute diseases
First Claim
1. A hemofiltration system operable to treat an Inflammatory Mediator Related Disease in a mammal comprising:
- a hemofilter having a molecular weight exclusion limit equal to or greater than approximately 69,000 Daltons, operable to remove an ultrafiltrate from a blood stream extracted from the mammal and to create a filtered blood stream in a return flow path to the mammal and an ultrafiltrate stream;
at least one therapeutic agent used in association with the hemofilter to treat the Inflammatory Mediator Related Disease, the therapeutic agent deliverable via the return flow path to the mammal; and
an adsorptive device containing at least one adsorbent material operable to receive the ultrafiltrate stream from the hemofilter and to remove an inflammatory mediator therefrom to create a post adsorption ultrafiltrate routable to at least one of the return flow path and waste.
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Accused Products
Abstract
A hemofiltration system and method to treat an Inflammatory Mediator Related Disease in a mammal, including chronic and acute diseases, include a hemofilter and an adsorptive device. The hemofilter removes ultrafiltrate from a blood stream extracted from the mammal to create a filtered blood stream and an ultrafiltrate stream. The adsorptive device may include one or more adsorbent materials and may be used to adsorb inflammatory mediators from the ultrafiltrate stream received from the hemofilter to create a post adsorption ultrafiltrate stream. The post adsorption ultrafiltrate stream may be selectively combined with the filtered blood stream and together with the filtered blood stream may be returned to the mammal.
104 Citations
24 Claims
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1. A hemofiltration system operable to treat an Inflammatory Mediator Related Disease in a mammal comprising:
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a hemofilter having a molecular weight exclusion limit equal to or greater than approximately 69,000 Daltons, operable to remove an ultrafiltrate from a blood stream extracted from the mammal and to create a filtered blood stream in a return flow path to the mammal and an ultrafiltrate stream; at least one therapeutic agent used in association with the hemofilter to treat the Inflammatory Mediator Related Disease, the therapeutic agent deliverable via the return flow path to the mammal; and an adsorptive device containing at least one adsorbent material operable to receive the ultrafiltrate stream from the hemofilter and to remove an inflammatory mediator therefrom to create a post adsorption ultrafiltrate routable to at least one of the return flow path and waste. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
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16. A hemofiltration system for treating an Inflammatory Mediator Related Disease in a mammal comprising:
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a hemofilter having a molecular weight exclusion limit equal to or greater than approximately 69,000 Daltons, operable to receive blood from a mammal, to selectively remove an inflammatory mediator from the blood, and to create a filtered blood stream in a return flow path to the mammal; at least one therapeutic agent used in association with the hemofilter to treat the Inflammatory Mediator Related Disease, the therapeutic agent deliverable via the return flow path to the mammal; and the therapeutic agent operable to reduce adverse effects of the inflammatory mediator. - View Dependent Claims (17, 18, 19, 20, 21, 22, 23, 24)
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Specification