Medical device including cylindrical micelles

• US 7,758,635 B2
• Filed: 02/13/2007
• Issued: 07/20/2010
• Est. Priority Date: 02/13/2007
• Status: Expired due to Fees

• Current Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Original Assignee: Boston Scientific Scimed, Inc. (Boston Scientific Corporation)
• Inventors: Parsonage, Edward
• Primary Examiner(s): Matthews; William H.
• Assistant Examiner(s): STROUD, JONATHAN R
• Application Number:
  US11/674,403
• Publication Number:
  US 20080195192A1
• Time in Patent Office: 1,253 Days
• Field of Search: 623 11- 154
• US Class Current: 623/1.41
• CPC Class Codes: A61F 2/0077 Special surfaces of prostheses, e.g. for improving ingrowth A61F2/30767 takes precedence
• CPC Class Codes: A61F 2/91 made from perforated sheet material or tubes, e.g. perforated by laser cuts or etched holes
• CPC Class Codes: A61F 2230/0054 V-shaped
• CPC Class Codes: A61F 2250/0067 Means for introducing or releasing pharmaceutical products into the body

Abstract

An endovascular stent comprising an expandable framework including a plurality of interconnected segments, and a plurality of entangled cylindrical micelles disposed on the expandable framework. Each of the plurality of cylindrical micelles may be loaded with a therapeutic agent.

Claims

1. A stent comprising:

an expandable framework having a first end, a second end, an outer diameter defining an outer surface, and an inner diameter defining an inner surface forming a lumen, the expandable framework including a plurality of interconnected segments; and

a plurality of cylindrical micelles incorporated with the expandable framework, the cylindrical micelles formed of multi-block amphiphilic copolymers self-assembling in a solution such that the cylindrical micelles have an outer shell region including a first polymer block of the multi-block amphiphilic copolymer surrounding a core region including a second polymer block of the multi-block amphiphilic copolymer, wherein the first polymer block is more soluble in the solution than the second polymer block.

2. The stent of claim 1, wherein the cylindrical micelles are loaded with a therapeutic agent.

3. The stent of claim 2, wherein the therapeutic agent is encapsulated within the core region of each of the cylindrical micelles.

4. The stent of claim 2, wherein the therapeutic agent is encapsulated within the outer shell region of each of the cylindrical micelles.

5. The stent of claim 2, wherein the therapeutic agent is encapsulated within the outer shell region and the core region of each of the cylindrical micelles.

6. The stent of claim 2, wherein the therapeutic agent includes a drug for the treatment of restenosis.

7. The stent of claim 2, wherein the therapeutic agent includes a drug promoting endocytosis.

8. The stent of claim 1, wherein the plurality of cylindrical micelles are disposed adjacent the inner surface of the expandable framework.

9. The stent of claim 8, wherein a portion of the inner surface of the expandable framework is accessible through the plurality of cylindrical micelles.

10. The stent of claim 1, wherein the plurality of cylindrical micelles are disposed adjacent the outer surface of the expandable framework.

11. The stent of claim 10, wherein a portion of the outer surface of the expandable framework is accessible through the plurality of cylindrical micelles.

12. The stent of claim 1, wherein the plurality of cylindrical micelles surround each interconnected segment of the expandable framework.

13. The stent of claim 1, wherein the plurality of cylindrical micelles are adhered to a surface of the expandable framework.

14. The stent of claim 1, wherein the plurality of cylindrical micelles are not adhered to a surface of the expandable framework.

15. The stent of claim 1, wherein the plurality of cylindrical micelles forms a fibrous structure.

16. The stent of claim 1, wherein the plurality of cylindrical micelles has an average pore size of about 1 nanometer to about 1000 nanometers.

17. The stent of claim 1, wherein each of the cylindrical micelles has a diameter of about 10 nanometers to about 50 nanometers.

18. The stent of claim 1, wherein each of the cylindrical micelles has a length of about 0.1 micrometer to about 100 micrometers.

19. The stent of claim 1, wherein the first polymer block is a hydrophilic block and the second polymer block is a hydrophobic block.

20. The stent of claim 1, wherein the first polymer block is a hydrophobic block and the second polymer block is a hydrophilic block.