Biocompatible polyacrylate compositions for medical applications

• US 7,758,880 B2
• Filed: 03/31/2004
• Issued: 07/20/2010
• Est. Priority Date: 12/11/2002
• Status: Expired due to Fees

• Current Assignee: Advanced Cardiovascular Systems Incorporated (Abbott Laboratories)
• Original Assignee: Advanced Cardiovascular Systems Incorporated (Abbott Laboratories)
• Inventors: Hossainy, Syed F. A.
• Primary Examiner(s): Hartley; Michael G
• Application Number:
  US10/815,421
• Publication Number:
  US 20050169957A1
• Time in Patent Office: 2,302 Days
• Field of Search: None
• US Class Current: 424/423
• CPC Class Codes: A61K 31/445 Non condensed piperidines, e.g. piperocaine
• CPC Class Codes: A61K 31/74 Synthetic polymeric materials
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence
• CPC Class Codes: A61P 41/00 Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
• CPC Class Codes: A61P 9/10 for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
• CPC Class Codes: C08L 33/06 of esters containing only carbon, hydrogen and oxygen, which oxygen atoms are present only as part of the carboxyl radical

Abstract

A composition is disclosed comprising a structural component comprising linear acrylic homopolymers or linear acrylic copolymers and a biobeneficial component comprising copolymers having an acrylate moiety and a biobeneficial moiety.

Claims

1. A medical article comprising an implantable medical device and a coating deposited on at least a part of the device, the coating including:

(a) a structural component comprising a linear acrylic homopolymer or linear acrylic copolymer; and

(b) a biobeneficial component comprising a poly(ethylene glycol)-poly(n-butylmethacrylate)-poly(ethylene glycol) block copolymer having an acrylate moiety and a biobeneficial moiety.

2. The medical article of claim 1 wherein the implantable medical device is a stent.

3. The medical article of claim 1 wherein the mass ratio between the structural component and the biobeneficial component is between about 99:

1 and about 1;

1.

4. The medical article of claim 1 wherein the mass ratio between the structural component and the biobeneficial component is between about 19:

1 and about 9;

1.

5. The medical article of claim 1 wherein the mass ratio between the structural component and the biobeneficial component is about 3:

1.

6. The medical article of claim 1 wherein the acrylic homopolymer and linear acrylic copolymer have the structure:

7. The medical article of claim 1 wherein the acrylic homopolymer or linear acrylic copolymer are poly(methylmethacrylate), poly(ethylmethacrylate), poly(n-propyl methacrylate), poly(iso-propylmethacrylate), poly(n-butylrnethacrylate), poly(n-laurylmethacrylate), poly(2-hydroxyethylmethacrylate), poly(methylmethacrylate-co-2-hydroxyethyl methacrylate), poly(n-butylmethacrylatc-co-2-hydroxyethyl methacrylate), or mixtures thereof.

8. The medical article of claim 1 wherein the biobeneficial moiety is from poly(alkylene glycols), superoxide dismutate-mimetics (SODm), diazenium diolate type nitric oxide donors, polycationic peptides, polysaccharides, pyrrolidone, vitamin E, sulfonated dextrase, β

-phenoxyethanol, N,N-dimethylamino-2-ethanol, mannose-6-phosphate, sulfonic acid, derivatives of sulfonic acid, or mixtures thereof.

9. The medical article of claim 8 wherein the poly(alkylene glycols) are poly(ethylene glycol), poly(propylene glycol), poly(tetramethylene glycol), poly(ethylene glycol-co-propylene glycol), poly(ethylene oxide-co-propylene oxide), or mixtures thereof.

10. The medical article of claim 1 wherein the mass ratio between the acrylate moiety and the biobeneficial moiety is between about 99:

1 and about 1;

1.

11. The medical article of claim 1 wherein the mass ratio between the acrylate moiety and the biobeneficial moiety is between about 19:

1 and about 9;

1.

12. The medical article of claim 1 wherein the mass ratio between the acrylate moiety and the biobeneficial moiety is about 3:

1.