Porous calcium phosphate networks for synthetic bone material
First Claim
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1. A calcium phosphate spinodal decomposition product composition comprising a first phase comprising hydroxyapatite and tricalcium phosphate, and a second phase comprising a removable inorganic porogen, said phases interconnected and having continuous networks, said second phase interconnection having a substantially constant cross-sectional dimension.
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Abstract
A porous composition comprising a hydroxyapatite material, as can be made from a mixture of calcium phosphate, calcium oxide and a removable inorganic porogen. In other embodiments, the present invention provides a method of making such a porous hydroxyapatite material or using a ternary system to prepare a two-phase composition enroute to a biomimetic bone material.
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Citations
21 Claims
- 1. A calcium phosphate spinodal decomposition product composition comprising a first phase comprising hydroxyapatite and tricalcium phosphate, and a second phase comprising a removable inorganic porogen, said phases interconnected and having continuous networks, said second phase interconnection having a substantially constant cross-sectional dimension.
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6. A calcium phosphate spinodal decomposition product of a molten mixture comprising iron oxide, calcium oxide and calcium phosphate, said product within the immiscibility region of a phase diagram of a CaO—
- P2O5—
FeO ternary system, said product comprising two interconnected phases having continuous networks. - View Dependent Claims (7, 8, 9, 10)
- P2O5—
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11. A method of using a ternary system to prepare a biomimetic bone material, said method comprising:
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providing a mixture of a transition metal oxide, calcium oxide and calcium phosphate components, each said component in an amount sufficient to provide a spinodal decomposition product within the immiscibility region of a phase diagram of a CaO—
P2O5—
MO ternary system, where MO is selected from the group consisting of transition metal oxides;heating said mixture over a temperature range and a time sufficient for spinodal decomposition of said mixture, said spinodal decomposition product comprising two interconnected phases having continuous networks; and removing said MO component from said spinodal decomposition product, to provide a biomimetic bone material. - View Dependent Claims (12, 13, 14, 15)
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- 16. A composition comprising a calcium phosphate spinodal decomposition product comprising a first phase comprising hydroxyapatite and tricalcium phosphate, and a second phase comprising a removable inorganic porogen, said phases interconnected and having continuous networks, said porogen at least partially removed to provide said composition a matrix of interconnected pores.
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