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Electronic methods for the detection of analytes

  • US 7,759,073 B2
  • Filed: 02/05/2009
  • Issued: 07/20/2010
  • Est. Priority Date: 06/12/1997
  • Status: Expired due to Fees
First Claim
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1. A method of detecting a target analyte comprising:

  • a) contacting a sample comprising said target analyte with an electrode comprising a passivation agent monolayer comprising;

    i) a covalently attached first passivation species;

    ii) a covalently attached second passivation species comprising a self-associated binding ligand, whereby upon binding of said target analyte with said binding ligand, said binding ligand is released from self-association;

    iii) a redox active molecule; and

    b) detecting a change in a redox property of the redox active molecule as a result of the association of the target analyte with the binding ligand.

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