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Sensor chips

  • US 7,759,114 B2
  • Filed: 01/06/2006
  • Issued: 07/20/2010
  • Est. Priority Date: 07/08/2003
  • Status: Expired due to Fees
First Claim
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1. A biosensor comprising:

  • a solid support having a surface;

    a plurality of linkers attached to the surface, wherein each linker includes a head group that is bound to the surface, and a multidentate macrocylic tail group comprising 1-acetato-4-benzyl-1,4,7-triazacyclononane chelated to a metal ion; and

    a monolayer of molecules immobilised to the solid support by the plurality of linkers and having a binding affinity for an analyte, wherein each molecule of the monolayer contains a metal ion chelating tag that coordinates with the metal ion on a tail group of a linker, thereby holding a majority of the molecules of the monolayer in the same orientation with respect to the surface of the solid support.

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