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Identification of novel pathways, genes and promoter motifs regulating adipogenesis

  • US 7,759,318 B1
  • Filed: 05/27/2005
  • Issued: 07/20/2010
  • Est. Priority Date: 05/28/2004
  • Status: Expired due to Fees
First Claim
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1. A method of decreasing triglyceride accumulation in a preadipocyte or adipocyte cell comprising contacting a preadipocyte or adipocyte cell with an effective amount of a compound comprising an oligonucleotide consisting of 12 to 50 linked nucleosides, wherein said oligonucleotide has a nucleobase sequence that is at least 90% complementary to SEQ ID NO:

  • 29 as measured over the entirety of said oligonucleotide, wherein the oligonucleotide comprises at least one modified nucleobase, modified sugar, or modified internucleoside linkage, wherein said triglyceride accumulation is decreased, and wherein the compounds is single-stranded.

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