System and method for identifying tissue using low-coherence interferometry

• US 7,761,139 B2
• Filed: 01/26/2004
• Issued: 07/20/2010
• Est. Priority Date: 01/24/2003
• Status: Active Grant

• Current Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Original Assignee: The General Hospital Corporation (Mass General Brigham, Inc.)
• Inventors: Iftimia, Nicusor V., Tearney, Guillermo J., Shishkov, Milen Stefanov, Pitman, Martha, Bouma, Brett E.
• Primary Examiner(s): WINAKUR, ERIC FRANK
• Application Number:
  US10/765,430
• Publication Number:
  US 20050004453A1
• Time in Patent Office: 2,367 Days
• Field of Search: 600/473, 600/472, 600/160, 600/476
• US Class Current: 600/473
• CPC Class Codes: A61B 5/0066 Optical coherence imaging
• CPC Class Codes: A61B 5/415 the glands, e.g. tonsils, adenoids or thymus
• CPC Class Codes: A61B 5/416 the spleen
• CPC Class Codes: A61B 5/418 lymph vessels, ducts or nodes
• CPC Class Codes: A61B 5/6848 Needles
• CPC Class Codes: A61B 5/6852 Catheters

Abstract

An apparatus for needle biopsy with real time tissue differentiation using one dimensional interferometric ranging imaging, comprising a biopsy device having a barrel and a needle, an optical fiber inserted in the needle, and a fiber optic imaging system connected to the optical fiber. The imaging system obtains images and compares the optical properties and patterns to a database of normalized tissue sample images to determine different tissue types. The physician performing the biopsy obtains feedback via a feedback unit associated with the biopsy device and which is connected to the imaging system. The feedback unit can provide visual, audible or vibratory feedback as to tissue type encountered when the needle is inserted toward the target tissue. The feedback unit can be programmed for different biopsy procedures so that the user can actuate a button to select a display or other feedback mechanism for the desired procedure and anticipated tissue to be encountered.

Claims

1. An apparatus for identifying characteristics of tissue, comprising:

a radiation source configured to perform an axial scan of the tissue using radiation; and

an imaging system adapted to receive an axial scan radiation based on the axial scan, and to process data relating to the axial scan radiation to identify characteristics of the tissue,

wherein the imaging system includes an interferometer adapted to direct a portion of the radiation emitted by the radiation source into a sample arm and detecting radiation reflected from the tissue back through the sample arm,

wherein the imaging system identifies characteristics of the tissue by processing the axial scan radiation to provide the characteristics of the tissue, the axial scan radiation including radiation received from a reference arm and radiation received from the sample arm, and comparing the characteristics of the tissue with a database of characteristics of a plurality of tissue types, and

wherein at least one of (i) the radiation source is a swept wavelength optical source or (ii) the radiation source is a broad bandwidth light source and the imaging system includes a spectrometer.

2. The apparatus of claim 1, wherein the radiation source delivers radiation to the tissue via an optical fiber disposed in an insertion device having a distal end at least partially disposed within the insertion device and a proximal end.

3. The apparatus of claim 2, wherein the insertion device is configured to provide the distal end of the optical fiber adjacent to the tissue.

4. The apparatus of claim 3, wherein the insertion device is one of a barrel, a needle, and a stylet.

5. The apparatus of claim 1, wherein the interferometer directs another portion of the radiation into the reference arm.

6. The apparatus of claim 1, wherein the axial scan by the radiation source is configured to cause the tissue to change at least one of the following properties of the axial scan radiation:

backscattering, spectral properties, birefringence or Doppler shift.

7. The apparatus of claim 1, wherein the imaging system processes the axial scan radiation by performing at least one of standard deviation, average deviation, or slope of the axial reflectivity profile relating to the axial scan radiation.

8. The apparatus of claim 1, wherein the imaging system inputs data derived from the axial scan radiation into a statistical model to predict tissue type.

9. The apparatus of claim 8, wherein the statistical model extracts features from data derived from the axial scan radiation.

10. The apparatus of claim 8, wherein the statistical model is at least one of partial least squares or principle component analysis.

11. The apparatus of claim 1, wherein the imaging system identifies the characteristics of the tissue by determining reflectance characteristics of the axial scan radiation using interferometric ranging, and comparing the characteristics of the tissue with normalized reflectance characteristics of a plurality of types of tissue stored in a database.

12. The apparatus of claim 11, wherein the type of interferometric ranging is at least one of optical time domain reflectometry, spectral domain reflectometry and optical frequency domain reflectometry.

13. A method for identifying characteristics of tissue, comprising:

performing an axial scan of the tissue using radiation using a radiation source to generate an axial scan radiation; and

processing data relating to the axial scan radiation based on the axial scan to identify characteristics of the tissue using an imaging system, wherein a portion of the radiation emitted by the radiation source is directed into a sample arm and radiation reflected from the tissue back is obtained through the sample arm, wherein the processing step includes;

a) identifying characteristics of the tissue by processing the axial scan radiation to provide the characteristics of the tissue, the axial scan radiation including radiation received from a reference arm and radiation received from the sample arm, and

b) comparing the characteristics of the tissue with a database of characteristics of a plurality of tissue types,

wherein at least one of (i) the radiation source is a swept wavelength optical source or (ii) the radiation source is a broad bandwidth light source and the imaging system includes a spectrometer.

14. The method of claim 13, wherein the axial scan by the radiation source is configured to cause the tissue to change at least one of the following properties of the axial scan radiation:

backscattering, spectral properties, birefringence or Doppler shift.

15. The method of claim 13, wherein the processing procedure identifies the characteristics of the tissue by performing at least one of standard deviation of data associated with the axial scan radiation, average deviation of data associated with the axial scan radiation, and slope of the axial reflectivity profile of data associated with the axial scan radiation.

16. The method of claim 13, wherein the radiation source includes a light source delivers the radiation to perform the axial scan of the tissue via an optical fiber disposed in an insertion device having a distal end at least partially disposed within the insertion device and a proximal end.

17. The method of claim 13, wherein the processing procedure identifies the characteristics of the tissue by inputting data derived from the axial scan radiation into a statistical model to predict a tissue type.

18. The method of claim 13, wherein the processing procedure identifies the characteristics of the tissue by determining reflectance characteristics of the axial scan radiation using interferometric ranging and comparing the characteristics of the tissue with a database of stored normalized reflectance characteristics of a plurality of types of tissue.

19. A tangible computer-accessible storage medium storing a software program for identifying characteristics of tissue, wherein the software program, when executed by a processing arrangement, is configured to cause the processing arrangement to execute the procedures comprising:

causing a performance of an axial scan of the tissue using radiation using a radiation source; and

processing data relating to the axial scan radiation to identify characteristics of the tissue, wherein a portion of the radiation emitted by the radiation source is directed into a sample arm and radiation reflected from the tissue back is obtained through the sample arm, wherein the processing step includes;

a) identifying characteristics of the tissue by processing the axial scan radiation to provide the characteristics of the tissue, the axial scan radiation including radiation received from a reference arm and radiation received from the sample arm, and

b) comparing the characteristics of the tissue with a database of characteristics of a plurality of tissue types,

wherein at least one of (i) the radiation source is a swept wavelength optical source or (ii) the radiation source is a broad bandwidth light source and the processing arrangement is part of an imaging system which includes a spectrometer.

20. The storage medium of claim 19, wherein the axial scan by the radiation source is configured to cause the tissue to change at least one of the following properties of the axial scan radiation:

backscattering, spectral properties, birefringence or Doppler shift.

21. The storage medium of claim 19, wherein the processing step identifies the characteristics of the tissue by performing at least one of standard deviation of data associated with the axial scan radiation, average deviation of data associated with the axial scan radiation, and slope of the axial reflectivity profile of data associated with the axial scan radiation.

22. The storage medium of claim 19, wherein the radiation source delivers the radiation to perform the axial scan of the tissue via an optical fiber disposed in an insertion device having a distal end at least partially disposed within the insertion device and a proximal end.

23. The storage medium of claim 19, wherein the processing step identifies the characteristics of the tissue by inputting data derived from the axial scan radiation into a statistical model to predict tissue type.

24. The storage medium of claim 19, wherein the processing step identifies the characteristics of the tissue by determining reflectance characteristics of the axial scan radiation using interferometric ranging and comparing the characteristics of the tissue with a database of stored normalized reflectance characteristics of a plurality of types of tissue.

25. A software arrangement for identifying characteristics of tissue stored on a tangible computer-accessible storage medium, which, when executed by a processing arrangement, configures the processing arrangement to perform procedures comprising:

causing a performance of an axial scan of the tissue using radiation using a radiation source; and

processing data relating to the axial scan radiation to identify characteristics of the tissue, wherein a portion of the radiation emitted by the radiation source is directed into a sample arm and radiation reflected from the tissue back is obtained through the sample arm, wherein the processing step includes;

a) identifying characteristics of the tissue by processing the axial scan radiation to provide the characteristics of the tissue, the axial scan radiation including radiation received from a reference arm and radiation received from the sample arm, and

b) comparing the characteristics of the tissue with a database of characteristics of a plurality of tissue types,

wherein at least one of (i) the radiation source is a swept wavelength optical source or (ii) the radiation source is a broad bandwidth light source and the processing arrangement is part of an imaging system which includes a spectrometer.

26. The software arrangement of claim 25, wherein the axial scan by the radiation source is configured to cause the tissue to change at least one of the following properties of the axial scan radiation:

backscattering, spectral properties, birefringence or Doppler shift.

27. The software arrangement of claim 25, wherein the radiation source delivers the radiation to perform the axial scan of the tissue via an optical fiber disposed in an insertion device having a distal end at least partially disposed within the insertion device and a proximal end.

28. The software arrangement of claim 25, wherein the processing procedure identifies the characteristics of the tissue by inputting data derived from the axial scan radiation into a statistical model to predict tissue type.

29. The software arrangement of claim 25, wherein the processing procedure identifies the characteristics of the tissue by determining reflectance characteristics of the axial scan radiation using interferometric ranging and comparing the characteristics of the tissue with a database of stored normalized reflectance characteristics of a plurality of types of tissue.

30. An apparatus for identifying characteristics of tissue, comprising:

a radiation source configured to perform an axial scan of the tissue using radiation; and

an imaging system adapted to receive axial scan radiation based on the axial scan, receive data relating to the axial scan radiation that is based on at least one of a spectral domain low-coherence interferometry or an optical frequency domain reflectometry, and process the data to automatically identify characteristics of the tissue.

31. An apparatus for identifying characteristics of tissue, comprising:

a radiation source configured to perform an axial scan of the tissue using radiation; and

an imaging system adapted to receive axial scan radiation based on the axial scan, and to process data relating to the axial scan radiation to identify characteristics of the tissue, wherein the imaging system processes the axial scan radiation by performing at least one of standard deviation, average deviation, and slope of the axial reflectivity profile relating to the axial scan radiation.

32. An apparatus for identifying characteristics of tissue, comprising:

a radiation source configured to deliver radiation to the tissue; and

an imaging system adapted to receive the radiation and process unidimensional data relating to the radiation that is based on at least one of a spectral domain low-coherence interferometry or an optical frequency domain reflectometry to identify characteristics of the tissue.