Transdermal electrotransport delivery device including an antimicrobial compatible reservoir composition
First Claim
1. A process for transdermally delivering a drug to or sampling a body analyte from a patient by electrotransport from an electrotransport device comprised of an anode, a cathode and a source of electrical power electrically connected to said anode and said cathode, at least one of said anode and said cathode including an electrode and a reservoir comprised of a housing, said housing comprised of a polymeric material and an aqueous medium in contact with said housing, said aqueous medium comprised of (i) a drug or an electrolyte salt, (ii) propylene glycol, and iii) an antimicrobial agent in an amount sufficient to inhibit microbial growth in said aqueous medium, wherein said propylene glycol is present in an amount that renders said antimicrobial agent compatible with said device, said process comprising:
- providing electric current from said source of electrical power so that said drug is transdermally delivered to or said body analyte sampled from said patient by electrotransport from or to one of said reservoirs.
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Accused Products
Abstract
A transdermal electrotransport drug delivery device having an anode, a cathode and a source of electrical power electrically connected to the anode and the cathode. At least one of the anode and the cathode includes an electrode and a reservoir comprised of a housing composed of a polymeric material and an aqueous medium in contact with the housing. The aqueous medium includes (i) a drug or an electrolyte salt or a mixture thereof, (ii) propylene glycol, and (iii) an antimicrobial agent in an amount sufficient to inhibit microbial growth in the aqueous medium. The propylene glycol prevents the antimicrobial agent from being adsorbed by other materials used in the construction of the delivery device. A process for preparing a transdermal electrotransport drug delivery device is also provided.
26 Citations
20 Claims
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1. A process for transdermally delivering a drug to or sampling a body analyte from a patient by electrotransport from an electrotransport device comprised of an anode, a cathode and a source of electrical power electrically connected to said anode and said cathode, at least one of said anode and said cathode including an electrode and a reservoir comprised of a housing, said housing comprised of a polymeric material and an aqueous medium in contact with said housing, said aqueous medium comprised of (i) a drug or an electrolyte salt, (ii) propylene glycol, and iii) an antimicrobial agent in an amount sufficient to inhibit microbial growth in said aqueous medium, wherein said propylene glycol is present in an amount that renders said antimicrobial agent compatible with said device, said process comprising:
- providing electric current from said source of electrical power so that said drug is transdermally delivered to or said body analyte sampled from said patient by electrotransport from or to one of said reservoirs.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20)
Specification