Capture verification with intrinsic response discrimination

• US 7,761,162 B2
• Filed: 12/13/2004
• Issued: 07/20/2010
• Est. Priority Date: 12/13/2004
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Meyer, Scott A., Dong, Yanting, Zhu, Qingsheng
• Primary Examiner(s): Layno; Carl H
• Assistant Examiner(s): Gedeon; Brian T
• Application Number:
  US11/010,973
• Publication Number:
  US 20060129196A1
• Time in Patent Office: 2,045 Days
• Field of Search: 607/28, 600/508
• US Class Current: 607/28
• CPC Class Codes: A61N 1/3712 Auto-capture, i.e. automatic adjustment of the stimulation threshold

Abstract

Approaches to automatically classifying a cardiac response to pacing involve discriminating between a captured response and non-capture with intrinsic activation. A capture detection system senses for morphological characteristics of a cardiac signal associated with the pacing pulse. The cardiac signal may be sensed using a defibrillation electrode during one or more time intervals following delivery of the pacing pulse. If a first characteristic of the cardiac signal achieves a threshold value, the system continues to sense the cardiac signal and detects a second characteristic. The cardiac pacing response is determined based on at least one of the first and the second cardiac signal characteristics.

Claims

1. A method of automatically classifying a cardiac response to a pacing pulse and delivering therapy, comprising:

sensing a cardiac signal associated with the pacing pulse;

detecting morphological characteristics of the cardiac signal and measuring a feature value of each of the morphological characteristics;

comparing at least one feature value to at least another feature value;

selecting, based on comparison of the feature values, one or more of the feature values to use for intrinsic response detection;

classifying the cardiac response to the pacing pulse including discriminating between capture and non-capture with intrinsic activity based on comparison of the selected one or more feature values to at least one reference value indicative of an intrinsic response; and

controlling pacing therapy based on the cardiac response to the pacing pulse.

2. The method of claim 1, wherein:

detecting the morphological characteristics of the cardiac signal comprises detecting first and second peaks having the same polarity;

selecting the feature values comprises selecting a greater peak magnitude; and

discriminating between capture and-non-capture with intrinsic activity comprises comparing the selected peak magnitude to a peak reference value indicative of the intrinsic response.

3. The method of claim 1, wherein sensing the cardiac signal comprises sensing the cardiac signal using a defibrillation electrode.

4. The method of claim 1, wherein sensing the cardiac signal comprises sensing the cardiac signal using a right ventricular tip electrode and a right ventricular coil electrode or a right ventricular ring electrode and a right ventricular coil electrode.

5. The method of claim 1, wherein sensing the cardiac signal comprises sensing the cardiac signal using a left ventricular distal electrode and a left ventricular coil electrode or a left ventricular proximal electrode and a left ventricular coil electrode.

6. The method of claim 1, wherein sensing the cardiac signal comprises sensing the cardiac signal using a right atrial tip electrode and a superior vena-cava coil electrode or a right atrial ring electrode and a superior vena-cava coil electrode.

7. The method of claim 1, wherein sensing the cardiac signal comprises sensing the cardiac signal using a left atrial distal electrode and a left atrial coil electrode or a left atrial proximal electrode and a left atrial coil electrode.

8. The method of claim 1, wherein sensing the cardiac signal comprises sensing the cardiac signal following a blanking period, wherein a duration of the blanking period is selected to allow a pacing artifact signal component to dissipate from the sensed cardiac signal.

9. The method of claim 1, further comprising classifying the cardiac response as non-capture if a feature value of a morphological characteristic does not achieve a capture threshold criteria.

10. The method of claim 1, wherein detecting morphological characteristics of the cardiac signal comprises:

timing a first time interval following the pacing pulse;

detecting a first morphological characteristic within the first time interval following the pacing pulse;

timing a second time interval following the first time interval; and

detecting a second morphological characteristic within the second time interval following the first time interval.

11. The method of claim 10, wherein:

detecting the first morphological characteristic comprises detecting a first peak of the cardiac signal in the first time interval; and

detecting the second morphological characteristic comprises detecting a second peak of the cardiac signal in the second time interval.

12. The method of claim 11, wherein:

selecting the feature values comprises selecting a feature value associated with the first peak or a feature value associated with the second peak; and

discriminating between capture and non-capture with intrinsic activity comprises comparing the selected one or more feature values to a reference value indicative of the intrinsic response.

13. The method of claim 1, wherein:

detecting the morphological characteristics of the cardiac signal and measuring a feature value of each of the morphological characteristics comprises;

detecting a first cardiac signal characteristic in a first time interval and measuring a first feature value of the first cardiac signal characteristic; and

detecting a second cardiac signal characteristic in a second time interval and measuring a second feature value of the second cardiac signal characteristic;

comparing at least one feature value with at least another feature value comprises comparing the first feature value with the second feature value;

selecting the feature values comprises selecting a larger feature value of the first and the second feature values; and

discriminating between capture and non-capture with intrinsic activity comprises comparing the larger feature value to the reference value indicative of the intrinsic response.

14. The method of claim 13, further comprising:

determining an average feature value of a plurality of cardiac signals representative of captured cardiac responses; and

updating the reference value based on the average feature value.

15. The method of claim 14, wherein determining the average feature value of the plurality of cardiac signals comprises determining a weighted average.

16. A capture detection system configured to classify a cardiac pacing response, comprising:

a plurality of cardiac electrodes configured to electrically couple to a heart;

a sensing system, coupled to the cardiac electrodes and configured to sense a cardiac signal associated with a pacing pulse using the plurality of cardiac electrodes;

a capture detector coupled to the sensing system, the capture detector configured to;

detect morphological characteristics of the cardiac signal;

measure a feature value of each of the morphological characteristics;

compare at least one feature value to at least another feature value;

select, based on comparison of the feature values, one or more of the feature values for use in discriminating between capture and non-capture with intrinsic activity of the cardiac signal;

compare the one or more selected feature values to at least one reference value indicative of intrinsic activity; and

classify the cardiac pacing response to the pacing pulse based on the comparison of the one or more selected feature values to the at least one reference value indicative of intrinsic activity; and

pacing circuitry configured to deliver pacing therapy based on the classification of the cardiac pacing response.

17. The system of claim 16, wherein the capture detector is configured to sense a first characteristic of the cardiac signal in a first time interval and to sense a second characteristic of the cardiac signal in a second time interval.

18. The system of claim 17, wherein one or both of the first and second time intervals are programmable.

19. The system of claim 16, wherein the plurality of cardiac electrodes comprises a right ventricular tip electrode and a right ventricular coil electrode or a right ventricular ring electrode and a right ventricular coil electrode.

20. The system of claim 16, wherein the plurality of cardiac electrodes comprises a left ventricular distal electrode and a left ventricular coil electrode or a left ventricular proximal electrode and a left ventricular coil electrode.

21. The system of claim 16, wherein the plurality of cardiac electrodes comprises a right atrial tip electrode and a superior vena-cava coil electrode or a right atrial ring electrode and a superior vena-cava coil electrode.

22. The system of claim 16, wherein the plurality of cardiac electrodes comprises a left atrial distal electrode and a left atrial coil electrode or a left atrial proximal electrode and a left atrial coil electrode.

23. The system of claim 16, wherein the sensing system is configured to sense the cardiac signal following a blanking period, wherein a duration of the blanking period is selected to allow a majority of a pacing artifact signal component to dissipate from the sensed cardiac signal.

24. The system of claim 16, wherein the capture detector is configured to classify the cardiac response to the pacing pulse as non-capture if a feature value of a first characteristic is not consistent with a capture threshold criteria.

25. The system of claim 24, wherein the capture threshold criteria is based on a weighted average value of previously sensed first characteristics associated with capture.

26. The system of claim 16, wherein the feature values include a first peak value of a first cardiac signal peak occurring in a first time interval and a second peak value of a second cardiac signal peak occurring in a second time interval, the first and second cardiac signal peaks having the same polarity.

27. The system of claim 26, wherein the at least one reference value is based on an average peak value of intrinsic responses.

28. The system of claim 26, wherein the capture detector is configured to select a larger of the first peak value having a first polarity and the second peak value of the same polarity and to discriminate between capture and non-capture with intrinsic activity based on comparison of the larger peak value to the reference value indicative of the intrinsic response.

29. A system for automatically classifying a cardiac response to a pacing pulse, comprising:

means for sensing a cardiac signal associated with the pacing pulse;

means for detecting morphological characteristics of the cardiac signal and measuring a feature value of each of the morphological characteristics;

means for comparing at least one feature value to at least one other feature value;

means for selecting, based on comparison of the feature values, one or more of the feature values to use for intrinsic response detection;

means for classifying the cardiac response to the pacing pulse by discriminating between capture and non-capture with intrinsic activity based on comparison of the selected one or more feature values to at least one reference value indicative of an intrinsic response; and

means for delivering cardiac pacing therapy based on cardiac pacing response classification.

30. The system of claim 29, further comprising means for classifying the cardiac response as non-capture without intrinsic activity if a first feature value does not achieve a threshold level.

31. The system of claim 29, wherein the means for detecting detects a first characteristic of the cardiac signal sensed in a first time interval and detects a second characteristic of the cardiac signal sensed in a second time interval.

32. The system of claim 29, wherein:

the means for detecting detects a first positive peak of the cardiac signal in a first time interval and detects a second positive peak of the cardiac signal in a second time interval;

the means for selecting the feature values selects a larger positive peak value of the first and the second positive peak values; and

the means for discriminating compares the larger positive peak value to the reference value indicative of an intrinsic response and discriminates between capture and non-capture with intrinsic activity based on the comparison.

33. The system of claim 29, further comprising:

means for determining an average peak value of a plurality of captured cardiac response signals; and

means for determining the reference value indicative of an intrinsic response based on the average peak value.

34. The system of claim 29, wherein the reference value indicative of an intrinsic response comprises an average value of intrinsic responses.