Electrical stimulation of iliohypogastric nerve to alleviate chronic pelvic pain

• US 7,761,166 B2
• Filed: 04/28/2006
• Issued: 07/20/2010
• Est. Priority Date: 04/28/2006
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Giftakis, Jonathan E., Gerber, Martin T.
• Primary Examiner(s): Layno; Carl H
• Assistant Examiner(s): Gedeon; Brian T
• Application Number:
  US11/414,614
• Publication Number:
  US 20070255340A1
• Time in Patent Office: 1,544 Days
• Field of Search: 607/45, 607/39, 607/40, 607/46, 607/143
• US Class Current: 607/46
• CPC Class Codes: A61K 31/485 Morphinan derivatives, e.g. morphine, codeine
• CPC Class Codes: A61K 31/7076 containing purines, e.g. adenosine, adenylic acid
• CPC Class Codes: A61K 38/31 Somatostatins
• CPC Class Codes: A61M 2005/1405 Patient controlled analgesia [PCA]
• CPC Class Codes: A61M 2205/054 with electrotherapy
• CPC Class Codes: A61M 2205/3523 using telemetric means
• CPC Class Codes: A61M 2205/50 with microprocessors or computers
• CPC Class Codes: A61M 2210/1021 Abdominal cavity
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/172 electrical or electronic A61M5/16804, A61M5/16831 take precedence
• CPC Class Codes: A61N 1/0551 Spinal or peripheral nerve electrodes
• CPC Class Codes: A61N 1/0556 Cuff electrodes
• CPC Class Codes: A61N 1/36007 of urogenital or gastrointestinal organs, e.g. for incontinence control
• CPC Class Codes: A61N 1/36071 Pain
• CPC Class Codes: A61N 1/37288 Communication to several implantable medical devices within one patient

Abstract

A method and system for applying electrical stimulation to an iliohypogastric nerve of a patient. The system includes electrical stimulators that apply electrical stimulation for alleviation of pelvic pain. The system may apply electrical stimulation for pelvic pain in men or women. The electrical stimulators may comprise various types of electrodes such as cuff electrodes, electrode leads, and microstimulators implanted at various locations proximate to a single or both iliohypogastric nerves of a patient. In particular, the electrode may be implanted proximate or adjacent to an anterior cutaneous branch of one or both iliohypogastric nerves, a lateral cutaneous branch of one or both iliohypogastric nerves, or one or both of iliohypogastric nerves above the branch point.

Claims

1. A method comprising applying electrical stimulation, which is selected to alleviate pelvic pain, to at least one of an anterior cutaneous nerve branch and a lateral cutaneous nerve branch of an iliohypogastric nerve of a patient via an implanted electrical stimulation device, wherein applying electrical stimulation comprises:

positioning an electrode of the electrical stimulation device proximate to at least one of the anterior cutaneous nerve branch and the lateral cutaneous nerve branch after the iliohypogastric nerve has branched to form the anterior cutaneous nerve branch and the lateral cutaneous nerve branch; and

applying electrical stimulation via the electrode.

2. The method of claim 1, further comprising applying electrical stimulation to the iliohypogastric nerve, via the implanted electrical stimulation device, at a point prior to the iliohypogastric nerve branching to form the anterior cutaneous nerve branch and the lateral cutaneous nerve branch.

3. The method of claim 2, wherein applying electrical stimulation comprises applying, on an alternating basis, electrical stimulation at points prior to and after the iliohypogastric nerve branching to form the anterior cutaneous nerve branch and the lateral cutaneous nerve branch.

4. The method of claim 1, further comprising applying electrical stimulation to at least one of a second anterior cutaneous nerve branch and a second lateral cutaneous nerve branch of a second iliohypogastric nerve of the patient, wherein applying electrical stimulation to at least one of the second anterior cutaneous nerve branch and the second lateral cutaneous nerve branch comprises:

positioning a second electrode proximate to at least one of the second anterior cutaneous nerve branch and the second lateral cutaneous nerve branch after the second iliohypogastric nerve has branched to form the second anterior cutaneous nerve branch and the second lateral cutaneous nerve branch; and

applying electrical stimulation via the second electrode.

5. The method of claim 4, wherein applying electrical stimulation comprises applying, on an alternating basis, electrical stimulation to the at least one of the anterior cutaneous nerve branch and the lateral cutaneous nerve branch of the iliohypogastric nerve and the at least one of the anterior cutaneous nerve branch and the lateral cutaneous nerve branch of the second iliohypogastric nerve.

6. The method of claim 1, wherein the pelvic pain includes at least one of chronic groin pain, chronic testicular pain (CTP), post vasectomy pain, iliohypogastric neuralgia, vulvodynia, and interstitial cystitis.

7. The method of claim 1, wherein the electrode includes at least one of a cuff electrode, a ring electrode, a planar electrode or an electrode on a leadless stimulator.

8. The method of claim 1, wherein the electrode includes a cuff electrode including a cuff-like fixation structure and one or more electrodes.

9. The method of claim 8, wherein the cuff electrode is mounted to an implantable medical lead coupled to the implantable electrical stimulation device.

10. The method of claim 8, wherein the implantable electrical stimulation device includes a leadless stimulator, and the cuff electrode is mounted to the leadless stimulator.

11. The method of claim 1, wherein the implantable electrical stimulation device includes a leadless stimulator sized for at least partial implantation within tissue proximate to the iliohypogastric nerve of the patient.

12. A method comprising applying electrical stimulation, which is selected to alleviate pelvic pain, to first and second iliohypogastric nerves of a patient by an implanted electrical stimulation device, wherein applying electrical stimulation comprises:

positioning at least one electrode proximate to at least one of an anterior cutaneous nerve branch and a lateral cutaneous nerve branch of at least one of the first and second iliohypogastric nerves; and

applying electrical stimulation via the at least one electrode.

13. The method of claim 12, wherein the pelvic pain includes at least one of chronic groin pain, chronic testicular pain (CTP), post vasectomy pain, iliohypogastric neuralgia, vulvodynia, and interstitial cystitis.

14. The method of claim 12, wherein the at least one electrode comprises a first electrode and a second electrode, and wherein positioning the at least one electrode comprises:

positioning the first electrode proximate to at least one of a first anterior cutaneous nerve branch and a first lateral cutaneous nerve branch of the first iliohypogastric nerve; and

positioning the second electrode proximate to at least one of a second anterior cutaneous nerve branch and a second lateral cutaneous nerve branch of the second iliohypogastric nerve.

15. The method of claim 12, wherein the at least one electrode comprises at least one of a cuff electrode, a ring electrode, a planar electrode or an electrode on a leadless stimulator.

16. The method of claim 12, wherein the implanted electrical stimulation device includes a leadless stimulator sized for at least partial implantation within tissue proximate to the first and second iliohypogastric nerves of the patient.

17. The method of claim 12, wherein applying electrical stimulation comprises applying electrical stimulation to the first and second iliohypogastric nerves on an alternating basis.

18. A method comprising applying electrical stimulation, which is selected to alleviate pelvic pain, to first and second iliohypogastric nerves on an alternating basis by an implanted electrical stimulation device, wherein applying electrical stimulation comprises applying electrical stimulation to at least one of an anterior cutaneous nerve branch and a lateral cutaneous nerve branch of at least one of the first and second iliohypogastric nerves.