Compliant microfluidic sample processing disks
First Claim
1. A microfluidic sample processing disk comprising:
- a body comprising first and second major surfaces;
a plurality of fluid structures, wherein each fluid structure of the plurality of fluid structures comprises;
an input well comprising an opening;
a process chamber located radially outward of the input well, wherein the process chamber comprises a void formed through the first and second major surfaces of the body; and
a delivery channel connecting the input well to the process chamber, wherein the delivery channel comprises an inner channel formed in the second major surface of the body, an outer channel formed in the first major surface of the body, and a via formed through the first and second major surfaces of the body, wherein the via connects the inner channel to the outer channel;
wherein the vias and the process chambers of the plurality of fluid structures define annular rings on the body;
a first annular cover attached to the first major surface of the body, the first annular cover defining the vias, the outer channels, and the process chambers in connection with the first major surface of the body;
a second annular cover attached to the second major surface of the body, the second annular cover defining the process chambers of the plurality of fluid structures in connection with the second major surface of the body, wherein an inner edge of the second annular cover is located radially outward of the annular ring defined by the vias of the plurality of fluid structures; and
a central cover attached to the second major surface of the body, the central cover defining the inner channels and the vias in connection with the second major surface of the body, wherein an outer edge of the central cover is located radially outward of the annular ring defined by the vias of the plurality of fluid structures.
4 Assignments
0 Petitions
Accused Products
Abstract
Microfluidic sample processing disks with a plurality of fluid structures formed therein are disclosed. Each of the fluid structures preferably includes an input well and one or more process chambers connected to the input well by one or more delivery channels. The process chambers may be arranged in a compliant annular processing ring that is adapted to conform to the shape of an underlying thermal transfer surface under pressure. That compliance may be delivered in the disks of the present invention by locating the process chambers in an annular processing ring in which a majority of the volume is occupied by the process chambers. Compliance within the annular processing ring may alternatively be provided by a composite structure within the annular processing ring that includes covers attached to a body using pressure sensitive adhesive.
-
Citations
31 Claims
-
1. A microfluidic sample processing disk comprising:
-
a body comprising first and second major surfaces; a plurality of fluid structures, wherein each fluid structure of the plurality of fluid structures comprises; an input well comprising an opening; a process chamber located radially outward of the input well, wherein the process chamber comprises a void formed through the first and second major surfaces of the body; and a delivery channel connecting the input well to the process chamber, wherein the delivery channel comprises an inner channel formed in the second major surface of the body, an outer channel formed in the first major surface of the body, and a via formed through the first and second major surfaces of the body, wherein the via connects the inner channel to the outer channel; wherein the vias and the process chambers of the plurality of fluid structures define annular rings on the body; a first annular cover attached to the first major surface of the body, the first annular cover defining the vias, the outer channels, and the process chambers in connection with the first major surface of the body; a second annular cover attached to the second major surface of the body, the second annular cover defining the process chambers of the plurality of fluid structures in connection with the second major surface of the body, wherein an inner edge of the second annular cover is located radially outward of the annular ring defined by the vias of the plurality of fluid structures; and a central cover attached to the second major surface of the body, the central cover defining the inner channels and the vias in connection with the second major surface of the body, wherein an outer edge of the central cover is located radially outward of the annular ring defined by the vias of the plurality of fluid structures. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13)
-
-
14. A microfluidic sample processing disk comprising:
-
a body comprising first and second major surfaces; a plurality of fluid structures, wherein each fluid structure of the plurality of fluid structures comprises; an input well comprising an opening; a process chamber located radially outward of the input well, wherein the process chamber comprises a void formed through the first and second major surfaces of the body; and a delivery channel connecting the input well to the process chamber; a first cover attached to the first major surface of the body with a pressure sensitive adhesive, the first cover defining a portion of the process chambers of the plurality of fluid structures in connection with the first major surface of the body; a second cover attached to the second major surface of the body with a pressure sensitive adhesive, the second cover defining a portion of the process chambers of the plurality of fluid structures in connection with the second major surface of the body, wherein the second cover comprises an inner edge and an outer edge that is located radially outward of the inner edge; wherein the process chambers of the plurality of fluid structures define an annular processing ring that comprises an inner edge and an outer edge located radially inward of a perimeter of the body, wherein the inner edge of the annular processing ring is located radially outward of the inner edge of the second cover. - View Dependent Claims (15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
-
-
26. A microfluidic sample processing disk comprising:
-
a body that comprises first and second major surfaces; an annular processing ring comprising a plurality of process chambers formed in the body, each process chamber of the plurality of process chambers defining an independent volume for containing sample material; an annular metallic layer located within the annular processing ring, wherein the annular metallic layer is proximate the first surface of the body, wherein the plurality of process chambers are located between the annular metallic layer and the second major surface of the body; a plurality of channels formed in the body, wherein each channel of the plurality of channels is in fluid communication with at least one process chamber of the plurality of process chambers; wherein the annular processing ring comprises a compliant structure in which the independent volumes of the plurality of process chambers maintain fluidic integrity when a portion of the annular processing ring is deflected in a direction normal to the first and second major surfaces of the body. - View Dependent Claims (27, 28, 29, 30, 31)
-
Specification