Therapeutic foam
First Claim
1. A method of making a foam comprising:
- providing two syringes connected by a connector, wherein syringe one is charged with a liquid phase and syringe two is charged with a gas phase, syringe one is charged with the liquid phase and the gas phase, or both syringes are charged with the liquid phase and the gas phase; and
transferring the liquid phase and the gas phase repeatedly between the syringes to form a foam, whereinthe liquid phase comprises at least one sclerosing agent andthe gas phase consists essentially of gaseous nitrogen present in an amount ranging from 0.01% to 0.8% by volume and a physiologically acceptable gas mixture comprising 10% to 90% vol/vol carbon dioxide with the remaining gas oxygen.
3 Assignments
0 Petitions
Accused Products
Abstract
A therapeutic foam for the treatment of, inter alia, varicose veins comprises a sclerosing solution foamed with a physiological gas such as carbon dioxide, oxygen or a mixture thereof. The foam has a nitrogen content of less than 0.8%. It may be generated using a pressurised canister system incorporating a fine mesh of micron dimensions through which the gas and sclerosing liquid are passed to make the foam. Alternatively, the foam may be generated by passing gas and solution between two syringes through a fine mesh. Techniques are described for minimising the amount of nitrogen in a canister or syringe based product. A technique for generating and delivering foam simultaneously using a syringe based device is also disclosed.
62 Citations
13 Claims
-
1. A method of making a foam comprising:
-
providing two syringes connected by a connector, wherein syringe one is charged with a liquid phase and syringe two is charged with a gas phase, syringe one is charged with the liquid phase and the gas phase, or both syringes are charged with the liquid phase and the gas phase; and transferring the liquid phase and the gas phase repeatedly between the syringes to form a foam, wherein the liquid phase comprises at least one sclerosing agent and the gas phase consists essentially of gaseous nitrogen present in an amount ranging from 0.01% to 0.8% by volume and a physiologically acceptable gas mixture comprising 10% to 90% vol/vol carbon dioxide with the remaining gas oxygen. - View Dependent Claims (2, 3, 4, 5)
-
-
6. A method of making a foam comprising:
-
(a) providing a syringe comprising a barrel, a first plunger and a second plunger, the second plunger having an apertured plunger head which is adapted to be movable within the barrel independently of the first plunger, the syringe being charged with a liquid phase and a gas phase; and (b) oscillating the second plunger to form a foam; wherein the liquid phase comprises at least one sclerosing agent and the gas phase consists essentially of gaseous nitrogen present in an amount ranging from 0.01% to 0.8% by volume and a physiologically acceptable gas mixture comprising 10% to 90% vol/vol carbon dioxide with the remaining gas oxygen. - View Dependent Claims (7, 8, 9, 10)
-
-
11. A sterile pack comprising:
-
(a) a syringe charged with at least one liquid sclerosing agent and a gas mixture consisting essentially of gaseous nitrogen present in an amount ranging from 0.01% to 0.8% by volume and a physiologically acceptable gas mixture comprising 10% to 90% vol/vol carbon dioxide with the remaining gas oxygen; (b) a gas atmosphere inside the pack having substantially the same composition as the said gas mixture in the syringe. - View Dependent Claims (12, 13)
-
Specification