Mesoderm and definitive endoderm cell populations
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1. A method of generating a cell population enriched for endoderm cells comprising culturing mammalian embryoid bodies in the presence of a concentration of activin of at least 30 ng/ml, whereby said embryoid bodies differentiate to generate a cell population enriched for endoderm.
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Abstract
The present invention provides cell populations that are enriched for mesendoderm and mesoderm, and cell populations that are enriched for endoderm. The cell populations of the invention are useful for generating cells for cell replacement therapy.
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7 Claims
- 1. A method of generating a cell population enriched for endoderm cells comprising culturing mammalian embryoid bodies in the presence of a concentration of activin of at least 30 ng/ml, whereby said embryoid bodies differentiate to generate a cell population enriched for endoderm.
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