Specimen analysis method and specimen analysis device

• US 7,763,468 B2
• Filed: 10/19/2004
• Issued: 07/27/2010
• Est. Priority Date: 10/29/2003
• Status: Active Grant

• Current Assignee: ARKRAY, Inc
• Original Assignee: ARKRAY, Inc
• Inventors: Kawai, Takuji
• Primary Examiner(s): Soderquist; Arlen
• Application Number:
  US10/577,578
• Publication Number:
  US 20070031971A1
• Time in Patent Office: 2,107 Days
• Field of Search: 422 56- 58, 422/68.1, 422 8201- 8203, 436/34, 436/46, 436/50, 436/55, 436/95, 436149-151, 436/183
• US Class Current: 436/55
• CPC Class Codes: G01N 27/3273 Devices therefor, e.g. test element readers, circuitry details not specific to biochemical electrodes G01N33/4875
• CPC Class Codes: Y10T 436/11 Automated chemical analysis
• CPC Class Codes: Y10T 436/112499 with sample on test slide
• CPC Class Codes: Y10T 436/115831 Condition or time responsive
• CPC Class Codes: Y10T 436/12 Condition responsive control
• CPC Class Codes: Y10T 436/144444 Glucose

Abstract

The present invention relates to a technique for analyzing a sample by utilizing a double integration circuit (11) for outputting a physical quantity related to the output from an analytical tool (2). In the present invention, the time interval from when the output from the analytical tool (2) is inputted into the double integration circuit (11) till when the physical quantity is started to be outputted from the double integration circuit (11) differs before and after the supply of the sample to the analytical tool (2) is confirmed.

Claims

1. A sample analysis method comprising:

a first step of confirming that a sample is supplied to an analytical tool based on output from the analytical tool;

a second step of grasping a level of the output from the analytical tool in a predetermined time period after the supply of the sample to the analytical tool is confirmed, the grasping being performed at least once including at a time point when the predetermined time period has elapsed; and

a third step of performing computation necessary for the analysis of the sample;

wherein the grasping of the output from the analytical tool in the first step and the second step is performed based on output from a double integration circuit which is obtained by inputting the output from the analytical tool into the double integration circuit;

wherein the first step comprises grasping a level of the output from the double integration circuit repetitively at a first sampling time interval defined by a time period from start of the inputting into the double integration circuit until completion of the outputting from the double integration circuit; and

wherein, the second step comprises grasping a level of the output from the double integration circuit at a second sampling time interval defined by a time period from start of the inputting into the double integration circuit until completion of the outputting from the double integration circuit, the second sampling time interval being set longer than the first sampling time interval.

2. The sample analysis method according to claim 1, wherein the second step comprises performing the inputting of the output from the analytical tool into the double integration circuit and the outputting from the double integration circuit repetitively at the second time interval, and grasping the output from the analytical tool at a time point when the predetermined time period has elapsed.

3. The sample analysis method according to claim 1, wherein the first sampling time interval is selected from a range of 10 to 30 msec, whereas the second sampling time interval is selected from a range of 30 to 300 msec.

4. The sample analysis method according to claim 1, wherein the double integration circuit includes a capacitor for storing the output from the analytical tool as an electric charge and then discharging the stored electric charge and is capable of grasping the output from the analytical tool based on a discharge time of the capacitor;

and

wherein a charge time of the capacitor in the first sampling time interval in the first step is shorter than a charge time of the capacitor in the second sampling time interval in the second step.

5. The sample analysis method according to claim 4, wherein the charge time of the capacitor in the first sampling time interval in the first step is selected from a range of 5 to 15 msec;

and

wherein the charge time of the capacitor in the second sampling time interval in the second step is selected from a range of 15 to 150 msec.

6. The sample analysis method according to claim 1, wherein the analytical tool includes an electrode for outputting an amount of electron transfer between the electrode and a particular component as an electric physical quantity.

7. The sample analysis method according to claim 6, wherein the analytical tool includes a reagent portion containing at least one reagent for promoting the electron transfer between the particular component and said electrode, and an additional electrode for applying, together with said electrode, voltage to a reaction system of the sample and said at least one reagent;

and

wherein the electric physical quantity is outputted from the analytical tool as a current value by applying voltage to the reaction system using said electrode and the additional electrode.

8. The sample analysis method according to claim 1, wherein the analytical tool is designed to use blood as the sample.

9. A sample analysis apparatus to be used with an analytical tool mounted thereto for analyzing a sample supplied to the analytical tool based on output from the analytical tool, the apparatus comprising:

a double integration circuit into which the output from the analytical tool is inputted and which outputs a physical quantity related to the input; and

a controller for controlling timing at which the output from the analytical tool is inputted into the double integration circuit and timing at which the physical quantity is outputted from the double integration circuit;

wherein the controller performs control so that a time interval from start of the inputting into the double integration circuit until start of the outputting from the double integration circuit becomes longer after the supply of the sample to the analytical tool is confirmed than before the supply of the sample to the analytical tool is confirmed.

10. The sample analysis apparatus according to claim 9, wherein the double integration circuit includes a capacitor for storing the output from the analytical tool as an electric charge and then discharging the stored electric charge and is capable of grasping the output from the analytical tool based on a discharge time of the capacitor;

and

wherein the controller performs control so that the charge time of the capacitor becomes longer after the supply of the sample to the analytical tool is confirmed than before the supply of the sample to the analytical tool is confirmed.

11. The sample analysis apparatus according to claim 10, wherein, when the analytical tool includes an electrode for outputting an electric physical quantity, the apparatus further comprises a switch for selecting a state in which the double integration circuit is directly or indirectly connected to ground or a state in which the double integration circuit is connected to the electrode;

and

wherein the controller controls the switch to control the timing at which the output from the analytical tool is inputted into the double integration circuit and the timing at which the physical quantity is outputted from the double integration circuit.