Quinolinone-carboxamide compounds as 5-HT4, receptor agonists
First Claim
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1. A method of treating chronic constipation in a mammal, the method comprising administering to the mammal a compound of formula (I):
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Abstract
The invention provides novel quinolinone-carboxamide 5-HT4 receptor agonist compounds. The invention also provides pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
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19 Claims
- 1. A method of treating chronic constipation in a mammal, the method comprising administering to the mammal a compound of formula (I):
- 5. A method of treating constipation-predominant irritable bowel syndrome in a mammal, the method comprising administering to the mammal a compound of formula (I):
- 9. A method of treating functional dyspepsia in a mammal, the method comprising administering to the mammal a compound of formula (I):
- 13. A method of treating gastroparesis in a mammal, the method comprising administering to the mammal a compound of formula (I):
- 17. A method of treating a mammal having a disease or medical condition mediated by treatment with a 5-HT4 receptor agonist, wherein the disease or medical condition is chronic constipation, constipation-predominant irritable bowel syndrome, functional dyspepsia, gastroparesis, gastroesophageal reflux disease, or drug-induced delayed transit, the method comprising administering to the mammal, a pharmaceutical composition comprising a pharmaceutically-acceptable carrier and a compound of formula (I):
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