Process for the preparation of functionalised polymer particles

• US 7,763,689 B2
• Filed: 08/21/2007
• Issued: 07/27/2010
• Est. Priority Date: 03/22/2000
• Status: Expired due to Term

• Current Assignee: Life Technologies AS (Perspecta, Inc.)
• Original Assignee: Dynal Biotech ASA (Thermo Fisher Scientific Incorporated)
• Inventors: Fonnum, Geir, Mork, Preben Cato, Nordal, Rolf, Weng, Ellen, Cockbain, Julian, Togersen, Svein, Aksnes, Elin Marie
• Primary Examiner(s): EGWIM, KELECHI CHIDI
• Application Number:
  US11/842,836
• Publication Number:
  US 20080039578A1
• Time in Patent Office: 1,071 Days
• Field of Search: 524/458, 524/73, 524/75, 524/201, 524/310, 523/200, 526/201
• US Class Current: 526/201
• CPC Class Codes: C08F 212/28 Amines
• CPC Class Codes: C08F 257/02 on to polymers of styrene or alkyl-substituted styrenes
• CPC Class Codes: C08F 285/00 Macromolecular compounds obtained by polymerising monomers on to preformed graft polymers
• CPC Class Codes: C08F 291/00 Macromolecular compounds obtained by polymerising monomers on to macromolecular compounds according to more than one of the groups C08F251/00 - C08F289/00
• CPC Class Codes: C08F 8/32 by reaction with amines

Abstract

A process for the preparation of amine-functionalized vinyl polymer particles which process comprises suspension polymerizing minostyrene together with at least one other vinylic monomer and optionally a crosslinking agent.

Claims

1. A process for the preparation of monodisperse amine-functionalised vinyl polymer particles wherein said polymer particles have a mode particle size of greater than 100 μ

m, which process comprises

(a) obtaining a first particulate polymer seed material having a mode particle diameter of at least 70 μ

m;

(b) using said first seed material, performing a first suspension polymerization to yield a second particulate polymer seed material having a mode particle diameter greater than that of said first seed material and, using said second seed material, performing at least one further suspension polymerization to yield a particulate polymer seed material, whereby the increase in mode particle volume in step (b) is at least ×

2;

wherein at least one of the suspension polymerizations effected in step (b) involves

(i) forming an aqueous dispersion comprising a polymer seed material, an organic compound which is a non-initiator or a first polymerization initiator having a molecular weight of less than 5000 daltons and a water solubility of less than 10<sup>−

2</sup> g/L at 25°

C., a hydroxyalkylmethylcellulose stabilizer and a first monomer;

(ii) allowing said organic compound and said first monomer to diffuse into the seed material to produce an activated seed material; and

(iii) contacting said activated seed material with a second monomer and with a second polymerization initiator whilst effecting suspension polymerization thereof, and that in at least the final suspension polymerization of step (b) the second monomer comprises amino styrene and at least one further vinylic monomer, and said second polymerisation initiator is an azo initiator.

2. The process as claimed in claim 1 wherein said vinyl polymer particles are styrenic polymer particles and said vinylic monomer is a styrenic monomer.

3. The process as claimed in claim 2 wherein said styrenic monomer is styrene.

4. The process as claimed in claim 1 wherein said first polymerisation initiator is selected from the group consisting of organic peroxides, peroxy esters and azo compounds.

5. The process as claimed in claim 4 wherein said non-initiator is bis (2-ethylhexyl)adipate or dioctyl adipate.

6. The process as claimed in claim 1 wherein at least one oil-soluble inhibitor is disposed in said second monomer.

7. The process as claimed in claim 1 wherein at least one water-soluble polymerization inhibitor is present in at least one of said polymerisation steps.

8. The process as claimed in claim 1 wherein seeds for a suspension polymerization stage are pre-swollen.

9. The process as claimed in claim 8 wherein seed material for a suspension polymerization is pre-swollen by direct addition of said first monomer in an amount of from 50 to 200 times the seed weight prior to effecting polymerisation.

10. A The process as claimed in claim 9 wherein said seed material is pre-swollen with amino styrene and said further vinylic monomer.

11. The process as claimed in claim 1 wherein said aminostyrene is 4-aminostyrene.