Neural stimulation system with pulmonary artery lead

• US 7,765,000 B2
• Filed: 05/10/2005
• Issued: 07/27/2010
• Est. Priority Date: 05/10/2005
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Zhang, Yongxing, Zhang, Yunlong
• Primary Examiner(s): Layno; Carl H
• Assistant Examiner(s): Kimball; Jeremiah T
• Application Number:
  US11/126,097
• Publication Number:
  US 20060259085A1
• Time in Patent Office: 1,904 Days
• Field of Search: 607/4, 607/5, 607/9, 607/14, 607/44, 607/117, 607/119, 607/122, 607/148
• US Class Current: 607/9
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions
• CPC Class Codes: A61N 1/3624 occurring in the atrium, i.e. atrial tachycardia
• CPC Class Codes: A61N 1/3627 for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
• CPC Class Codes: A61N 1/395 for treating atrial fibrillation
• CPC Class Codes: A61N 1/3956 Implantable devices for applying electric shocks to the heart, e.g. for cardioversion

Abstract

Various embodiments of the present subject matter relate to a method. According to various method embodiments, at least one lead is inserted through a pulmonary artery to securely position at least one electrode within the pulmonary artery. Neural stimulation is applied to a neural stimulation target using the at least one lead in the pulmonary artery. An atrial rhythm management activity, including at least one of capturing atrial tissue using the at least one lead and sensing an intrinsic atrial event, is performed using the at least one lead in the pulmonary artery. Other embodiments are provided herein.

Claims

1. A method, comprising:

positioning at least one lead with at least one electrode into a pulmonary artery; and

transvascularly stimulating a vagus nerve proximate to the pulmonary artery using the at least one electrode in the pulmonary artery,

wherein positioning at least one lead with at least one electrode into a pulmonary artery includes positioning at least one electrode in a right pulmonary artery and at least one electrode in a left pulmonary artery.

2. The method of claim 1, wherein the at least one electrode in the right pulmonary artery is positioned to transvascularly stimulate a right vagus nerve target, and the at least one electrode in the left pulmonary artery is positioned to transvascularly stimulate a left vagus nerve target.

3. The method of claim 1, comprising:

securely positioning the at least one electrode within the pulmonary artery; and

performing an atrial rhythm management activity using the at least one lead in the pulmonary artery, including at least one of capturing atrial tissue using the at least one lead and sensing an intrinsic atrial event using the at least one lead.

4. The method of claim 3, wherein transvascularly stimulating includes applying neural stimulation to a right vagus nerve target using the first electrode in the right pulmonary artery and applying neural stimulation to a left vagus nerve target using the second electrode in the left pulmonary artery.

5. The method of claim 3, wherein transvascularly stimulating includes applying neural stimulation to the vagus nerve using one of the at least one lead and performing the atrial rhythm management activity includes performing the atrial rhythm management activity using another lead in the pulmonary artery.

6. The method of claim 3, wherein performing the atrial rhythm management activity using the at least one lead in the pulmonary artery includes both capturing atrial tissue and sensing an intrinsic atrial event using the at least one lead in the pulmonary artery.

7. The method of claim 3, wherein performing the atrial rhythm management activity includes pacing atrial tissue using the at least one lead in the pulmonary artery.

8. The method of claim 3, wherein performing the atrial rhythm management activity includes applying an anti-tachycardia pulse to atrial tissue using the at least one lead in the pulmonary artery.

9. The method of claim 3, wherein performing the atrial rhythm management activity includes applying a defibrillation pulse to atrial tissue using the at least one lead in the pulmonary artery.

10. The method of claim 3, wherein transvascularly stimulating and performing the atrial rhythm management activity includes stimulating the vagus nerve to lower a shocking threshold for atrial tissue, and shocking the atrial tissue.

11. The method of claim 1, wherein positioning at least one lead includes:

inserting a bifurcated lead with a first branch and a second branch through a pulmonary valve;

inserting the first branch of the bifurcated lead into a right pulmonary artery to securely position at least one electrode within the right pulmonary artery; and

inserting the second branch of the bifurcated lead into a left pulmonary artery to securely position at least one electrode within the left pulmonary artery.

12. The method of claim 11, wherein transvascularly stimulating includes applying neural stimulation to a right vagus nerve target using the first branch of the bifurcated lead in the right pulmonary artery and applying neural stimulation to a left vagus nerve target using the second branch of the bifurcated lead in the left pulmonary artery.

13. The method of claim 11, wherein transvascularly stimulating includes applying neural stimulation to the vagus nerve using one of the first and second branches, the method further comprising performing an atrial rhythm management activity using the other of the first and second branches.

14. The method of claim 1, further comprising capturing atrial tissue using the at least one electrode in the pulmonary artery.

15. The method of claim 14, wherein capturing atrial tissue includes providing atrial pacing.

16. The method of claim 14, wherein capturing atrial tissue includes providing at least one of an atrial anti-tachycardia shock or an atrial defibrillation shock.

17. The method of claim 1, further comprising sensing an intrinsic atrial electrical event using the at least one lead in the pulmonary artery.