Nano- and micro-scale wireless stimulating probe

• US 7,765,013 B2
• Filed: 06/04/2007
• Issued: 07/27/2010
• Est. Priority Date: 06/04/2007
• Status: Active Grant

• Current Assignee: Wisconsin Alumni Research Foundation (University of Wisconsin System)
• Original Assignee: Wisconsin Alumni Research Foundation (University of Wisconsin System)
• Inventors: Lagally, Max G., Blick, Robert H.
• Primary Examiner(s): Layno; Carl H.
• Assistant Examiner(s): MORALES, JON ERIC C
• Application Number:
  US11/757,487
• Publication Number:
  US 20080300663A1
• Time in Patent Office: 1,149 Days
• Field of Search: 607/60, 607/62, 607/116, 600/573
• US Class Current: 607/116
• CPC Class Codes: A61N 1/37205 Microstimulators, e.g. implantable through a cannula
• CPC Class Codes: A61N 1/37223 Circuits for electromagnetic coupling
• CPC Class Codes: A61N 1/378 Electrical supply
• CPC Class Codes: B82Y 30/00 Nanotechnology for materials or surface science, e.g. nanocomposites

Abstract

Untethered micro or nanoscale probes may be dispersed within tissue to be individually addressed through external electromagnetic radiation to create local electrical currents used for direct stimulation, alteration of cellular potentials, or the release or modification of contained or attached chemical compounds.

Claims

1. A wirelessly stimulatable probe comprising:

an untethered, dispersible element attachable to tissue structure and substantially less than 100 micrometers in a longest dimension, the dispersible element absorbing electromagnetic radiation to produce an electrical current local to the dispersible element;

energy of the electromagnetic radiation providing the sole source of electrical power for the dispersible element in interacting with the tissue structure.

2. The wirelessly stimulatable probe of claim 1 wherein the dispersible element is a strain curved semiconductor membrane.

3. The wirelessly stimulatable probe of claim 2 wherein the strain curved semiconductor membrane is a tube having an overlap region comprising n and p type doped regions to form a heterojunction device.

4. The wirelessly stimulatable probe of claim 3 wherein the heterojunction device is a photodiode.

5. The wirelessly stimulatable probe of claim 1 wherein the dispersible element is a semiconductor membrane providing abutting n and p type doped regions.

6. The wirelessly stimulatable probe of claim 1 wherein the dispersible element further includes adhered chemicals activated by the electrical current.

7. The wirelessly stimulatable probe of claim 1 wherein the dispersible elements further include semiconductor circuitry activated by the electrical current.

8. The wirelessly stimulatable probe of claim 1 wherein the dispersible element includes adhered chemicals providing for biological interaction.

9. The wirelessly stimulatable probe of claim 1 further including a probe feature re-emitting energy of the received electromagnetic radiation modified by the probe.

10. A cellular scale addressable probe array comprising:

a plurality of untethered, dispersible elements attachable to spatially separated tissue structure, the dispersible elements less than 100 micrometers in a longest dimension and absorbing electromagnetic radiation to produce an electrical current local to the dispersible element, energy of the electromagnetic radiation providing substantially the sole source of electrical power for the dispersible element in interacting with the tissue structure; and

an electromagnetic radiation source steerable to produce the electrical current local to a predetermined subset of the dispersible elements.

11. The cellular scale addressable probe array of claim 10 wherein the electromagnetic radiation source is a laser.

12. A method of wirelessly stimulating tissue structure comprising:

locating one or more untethered, dispersible elements substantially less than 100 micrometers in a longest dimension in the tissue structure; and

stimulating the elements with electromagnetic radiation to produce an electrical current local to the elements, the electrical current generated substantially solely from energy of the stimulating electromagnetic radiation absorbed by the dispersible elements.

13. The method of claim 12 wherein the elements are strain curved semiconductor membranes.

14. The method of claim 13 wherein the strain curved semiconductor membrane is a tube having an overlap region comprising n and p type doped regions to form a heterojunction device.

15. The method of claim 14 wherein the heterojunction devices are photodiodes.

16. The method of claim 12 wherein the elements are semiconductor membranes providing abutting n and p type doped regions.

17. The method of claim 12 wherein the elements further include adhered chemicals activated by the electrical current.

18. The method of claim 12 wherein the elements further include semiconductor circuitry activated by the electrical current.

19. The method of claim 12 wherein the elements include adhered chemicals providing for biological interaction.

20. The method of claim 12 including multiple elements and including the step of steering the electromagnetic radiation source among elements to produce the electrical current local to different subsets of the elements at different times.

21. The method of claim 20 wherein the electromagnetic radiation source is a laser.

22. The method of claim 20 further including the step of re-emitting energy of the accepted electromagnetic radiation as modified by the probe.