Multiplexed latching valves for microfluidic devices and processors

• US 7,766,033 B2
• Filed: 03/21/2007
• Issued: 08/03/2010
• Est. Priority Date: 03/22/2006
• Status: Active Grant

• Current Assignee: Regents of the University of California (University of California)
• Original Assignee: Regents of the University of California (University of California)
• Inventors: Jensen, Erik C., Mathies, Richard A., Grover, William H.
• Primary Examiner(s): HEPPERLE, STEPHEN M
• Application Number:
  US11/726,701
• Publication Number:
  US 20070237686A1
• Time in Patent Office: 1,231 Days
• Field of Search: 137/597, 137/907, 422/103, 251/26, 251/29
• US Class Current: 137/297
• CPC Class Codes: B01L 2200/12 Specific details about manufacturing devices
• CPC Class Codes: B01L 2300/0816 Cards, e.g. flat sample carriers usually with flow in two horizontal directions
• CPC Class Codes: B01L 2300/0887 Laminated structure
• CPC Class Codes: B01L 2400/0638 membrane valves, flap valves
• CPC Class Codes: B01L 3/5025 for parallel transport of multiple samples
• CPC Class Codes: B01L 3/502738 characterised by integrated valves microvalves F16K99/0001
• CPC Class Codes: F16K 2099/0071 with latching means
• CPC Class Codes: F16K 2099/0074 using photolithography, e.g. etching
• CPC Class Codes: F16K 2099/0084 Chemistry or biology, e.g. "lab-on-a-chip" technology
• CPC Class Codes: F16K 99/0001 Microvalves microdevices B81B1/00; manufacture or treatment of devices or systems in or on a substrate B81C1/00; microfluidic structures B01L3/5027; micropumps F04B19/006
• CPC Class Codes: F16K 99/0015 Diaphragm or membrane valves
• CPC Class Codes: F16K 99/0034 Operating means specially adapted for microvalves
• CPC Class Codes: F16K 99/0059 actuated by a pilot fluid
• CPC Class Codes: Y10T 137/2218 Means [e.g., valve] in control input
• CPC Class Codes: Y10T 137/3115 Gas pressure storage over or displacement of liquid
• CPC Class Codes: Y10T 137/5474 With heater
• CPC Class Codes: Y10T 137/87249 Multiple inlet with multiple outlet

Abstract

Membrane valves and latching valve structures for microfluidic devices are provided. A demultiplexer can be used to address the latching valve structures. The membrane valves and latching valve structures may be used to form pneumatic logic circuits, including processors.

Claims

1. A microfluidic latching valve structure comprising:

an input to the structure;

first, second and third membrane valves, each valve including a valve input, a valve output, a valve control, and an elastomer membrane configured such that the application of a pressure or a vacuum to the valve control causes the membrane to deflect to modulate a flow of fluid through the valve; and

wherein;

(i) the input to the structure is configured to transmit pressure or vacuum to the valve input of the first membrane valve and to the valve input of the second membrane valve,

(ii) the valve outputs of the first and second membrane valves are in communication through a microfluidic channel when the first and second membrane valves are closed, and

(iii) the valve outputs of the first and second membranes valve are in communication with the valve control of the third membrane valve and the valve outputs of the first and second membrane valves are configured to transmit the pressure or vacuum to the valve control of the third membrane valve,

such that a sufficient vacuum at the input to the structure causes the third membrane valve to open and upon removal of the vacuum, the third membrane valve remains open and such that a sufficient pressure at the input to the structure causes the third membrane valve to close and upon removal of the pressure, the third membrane valve remains closed.

2. The latching valve structure of claim 1 configured to control fluid flow to an on-chip, microfluidic analytical device.

3. The latching valve structure of claim 1 configured to control a fluidic process of an assay of a microfluidic device.

4. The latching valve structure of claim 1 further including a demultiplexer configured to control an array of latching valve structures in performing an assay.

5. The microfluidic latching valve structure of claim 1 wherein the input to the structure comprises first and second input channels;

wherein

the valve input of the first membrane valve is in fluid communication with the first input channel and wherein the valve control of the first membrane valve is in fluid

the valve input of the second membrane valve is in fluid communication with the first input channel, and the valve control of the second membrane valve is in fluid communication with the second input channel;

such that when a sufficient vacuum is applied to the first and second input channels, the third membrane valve moves to an open position and is latched in that position when the vacuum is removed; and

such that when a sufficient pressure is applied to the first and second input channels, the third membrane valve moves to a closed position and is latched in that position when the pressure is removed.

6. The latching valve structure of claim 5 wherein the second input channel, the valve control of the first membrane valve, the valve control of the second membrane valve, and the valve input and valve output of the third membrane valve are formed in a first surface.

7. The latching valve of claim 6 wherein the first input channel, the valve input and valve output of the first membrane valve, the valve input and valve output of the second membrane valve, and the valve control of the third membrane valve are formed in a second surface opposite the first surface.

8. The latching valve structure of claim 7 wherein an elastomer membrane is located between the first and second surfaces at the area of the valve controls of the first, second and third membrane valves such that the application of a pressure or a vacuum at the first and second input channels causes the membrane to deflect to modulate a flow of a fluid through the first, second, or third membrane valve.

9. The latching valve structure of claim 5 further including:

a fourth membrane valve having a valve input in fluid communication with the control of the third membrane valve, a valve output in fluid communication with the valve control of the first membrane valve, and a valve control in fluid communication with atmospheric.

10. The latching valve structure of claim 5 wherein there are a plurality of latching valve structures and further including a microfluidic demultiplexer configured to address each of the latching valve structures with either a vacuum or a pressure pulse.

11. The latching valve structure of claim 10 wherein the demultiplexer includes a plurality of rows of membrane valves configured to distribute the pressure and vacuum pulses to each of the latching valve structures.

12. The latching valve structure of claim 11 further including two pneumatic connections for each row of membrane valves of the demultiplexer.

13. The latching valve structure of claim 11 wherein the demultiplexer has n-rows of membrane valves operated by n-solenoid valves to address 2ⁿ independent latching valve structures.

14. The latching valve structure of claim 11 wherein each row after the first row of membrane valves has twice the number of membrane valves of the previous row.

16. The latching valve structure of claim 5 wherein the valve input and the valve output of the third membrane valve are configured to form an input and output of the latching valve structure.

17. The latching valve structure of claim 1 wherein the valves are normally closed.

18. The latching valve structure of claim 1 wherein the input to the structure is connected to a source of vacuum or pressure.

19. The latching valve structure of claim 5 wherein the valves are normally closed.

20. The latching valve structure of claim 5 wherein the input to the structure is connected to a source of vacuum or pressure.

21. The latching valve structure of claim 1 wherein the input to the structure is configured to transmit pressure or vacuum to the valve input of the first membrane valve when the second membrane valve is closed and is configured to transmit pressure or vacuum to the valve input of the second membrane valve when the first membrane valve is closed.

15. A membrane valve structure comprising:

a first input channel formed in a first surface of a first substrate;

a second input channel formed in a second surface of a second substrate;

a pressure valve having a control formed in the first surface and fluidly connected with atmospheric, and an input and output formed in the second surface wherein the input is fluidly connected to the second input channel;

a vacuum valve having a control formed in the first surface and fluidly connected to a first input channel, and input and an output formed in the second surface such that the input is fluidly connected to the second input channel;

a latching valve having an input and output formed in the first surface, and a control formed in the second surface such that the control is fluidly connected to the output of the vacuum valve; and

an elastomer membrane located between the first and second surfaces at the area of the control of each of the pressure, vacuum and latching valves such that the application of a pressure or a vacuum to the first and second input channels causes the membrane to deflect to modulate a flow of a fluid through the valves.