Fluid delivery device with autocalibration

• US 7,766,864 B2
• Filed: 12/29/2008
• Issued: 08/03/2010
• Est. Priority Date: 10/09/2002
• Status: Expired due to Term

• Current Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Original Assignee: Abbott Diabetes Care Incorporated (Abbott Laboratories Incorporated)
• Inventors: Rush, Benjamin
• Primary Examiner(s): Lucchesi; Nicholas D
• Assistant Examiner(s): BERDICHEVSKY, AARTI
• Application Number:
  US12/345,595
• Publication Number:
  US 20090179044A1
• Time in Patent Office: 582 Days
• Field of Search: 604/65, 604/121, 604/122, 604/134, 604/151, 604/152, 604/67
• US Class Current: 604/67
• CPC Class Codes: A61M 2205/0288 Electro-rheological or magneto-rheological materials
• CPC Class Codes: A61M 2205/3317 Electromagnetic, inductive or dielectric measuring means
• CPC Class Codes: A61M 2205/702 automatically during use
• CPC Class Codes: A61M 5/14216 Reciprocating piston type
• CPC Class Codes: A61M 5/14244 adapted to be carried by the patient, e.g. portable on the body
• CPC Class Codes: F04B 2205/09 Flow through the pump
• CPC Class Codes: F04B 43/043 Micropumps
• CPC Class Codes: F04B 49/065 and making use of computers
• CPC Class Codes: F04B 51/00 Testing machines, pumps, or pumping installations
• CPC Class Codes: F05C 2251/08 Shape memory
• CPC Class Codes: G01F 1/708 Measuring the time taken to traverse a fixed distance
• CPC Class Codes: G01F 11/029 provided with electric controlling means G01F11/022 and G01F11/024 take precedence
• CPC Class Codes: G01F 25/0084 for measuring volume
• CPC Class Codes: G01F 25/10 of flowmeters
• CPC Class Codes: G05D 7/0694 by action on throttling means or flow sources of very small size, e.g. microfluidics microvalves F16K99/0001; microstructural devices per se B81B

Abstract

A micro fluid delivery device is particularly useful in medical applications. The device may be worn or carried by the user and may deliver drugs or other medicaments to the user or patient. The device has a control system that accepts input from the user and controls all aspects of operation of the device. The control system measures the output of the pump and adjusts the output of the pump to achieve the desired dosage rate and size. This eliminates differences from pump to pump that result from inevitable variations in the manufacturing of such small scale affordable devices.

Claims

1. A method of calibrating a volumetric flow rate of a fluid pumping device, the method comprising:

pumping a liquid using, at least in part, a shape memory element;

detecting arrival of the liquid at a first sensor, wherein the first sensor includes a plurality of electrodes;

detecting arrival of the liquid at a second sensor, wherein the second sensor includes a plurality of electrodes;

measuring the time elapsed from the arrival of the liquid at the first sensor to the arrival of the liquid at the second sensor and substantially simultaneously determining a flow characteristic of the liquid; and

adjusting the volumetric flow rate of the of the device, based, at least in part, on the measured time and the determined flow characteristic.

2. The method of claim 1, further comprising calculating the volumetric flow rate of the dispensing device.

3. The method of claim 1, wherein the flow characteristic of the liquid corresponds to a rate of an electrochemical reaction of a component of the liquid.

4. The method of claim 1, wherein pumping the liquid includes modifying the temperature of the shape memory element.

5. The method of claim 1, wherein the plurality of electrodes of the first sensor and the plurality of electrodes of the second sensor detect an interruption in a flow stream of the liquid.

6. The method of claim 1 wherein the dispensing device comprises a disposable portion, and wherein the method further comprises attaching the disposable portion to a re-usable portion of the device.

7. The method of claim 6, wherein after the disposable portion is attached, the volumetric flow rate of the dispensing device is adjusted.

8. The method of claim 1, further comprising determining a calibration factor based, at least in part, on the measured time and the flow characteristic.

9. The method of claim 8, wherein the calibration factor comprises a ratio of an expected volume of a dose compared to an actual volume of the dose.

10. A method of calibrating a disposable pumping component, the method comprising:

attaching a disposable pumping component to a reusable component, wherein the reusable component comprises a microprocessor and a shape memory element;

pumping a liquid from a reservoir through a known volume portion of the disposable pumping component using the shape memory element;

determining a flow characteristic of the liquid while pumping the liquid through the known volume portion;

determining an actual dosage volume based, at least in part, on a time to pump the liquid through the known volume portion and the determined flow characteristic;

determining a desired dosage volume; and

adjusting the actual dosage volume based on a comparison of the actual dosage volume and the desired dosage volume.

11. The method of claim 10, wherein adjusting the actual dosage volume includes modifying a frequency of dosage delivery.

12. The method of claim 10, wherein the flow characteristic of the liquid corresponds to a rate of an electrochemical reaction of a component of the liquid.

13. The method of claim 10, wherein pumping the liquid from the reservoir through the known volume portion of the disposable pumping component includes modifying the temperature of the shape memory element.

14. The method of claim 10, further comprising detecting arrival of the liquid at a first point of the known volume of the disposable pumping component using a first sensor having a plurality of electrodes and detecting arrival of the liquid at a second point of the known volume of the disposable pumping component using a second sensor having a plurality of electrodes.

15. The method of claim 14, wherein the plurality of electrodes of the first sensor and the plurality of electrodes of the second sensor detect an interruption in a flow stream of the liquid.

16. A method of calibrating a pumping system, the method comprising:

initiating flow of a liquid through a portion of the pumping system having a known volume using, at least in part, a shape memory element;

determining, using a plurality of sensors, a flow rate and a flow characteristic of the liquid as the liquid flows through the portion of the pumping system having the known volume;

determining an actual dosage volume based, at least in part, on the flow rate and the flow characteristic;

determining a desired dosage volume;

determining a calibration factor by comparing the desired dosage volume to the actual dosage volume; and

modifying delivery of the liquid based on the calibration factor.

17. The method of claim 16, wherein the flow characteristic of the liquid corresponds to a voltage of a reaction rate associated with a component of the liquid.

18. The method of claim 16, wherein modifying delivery of the liquid includes modifying a delivery profile based at least in part on the calibration factor.

19. The method of claim 18, wherein modifying the delivery profile includes modifying a timing of a subsequent dosage.

20. The method of claim 16, wherein determining the flow rate of the liquid comprises detecting arrival of the liquid at a first point of the portion of the pumping system having the known volume using a first sensor of the plurality of sensors and detecting arrival of the liquid at a second point of the portion of the pumping system having the known volume using a second sensor of the plurality of sensors.

21. The method of claim 20, wherein the first and second sensors of the plurality of sensors detect an interruption in a flow stream of the liquid.