Method and apparatus for application of a fluid

• US 7,766,900 B2
• Filed: 09/08/2005
• Issued: 08/03/2010
• Est. Priority Date: 02/21/2005
• Status: Expired due to Fees

• Current Assignee: Biomet Manufacturing, LLC (Zimmer Biomet Holdings, Inc.)
• Original Assignee: Biomet Manufacturing, LLC (Zimmer Biomet Holdings, Inc.)
• Inventors: Leach, Michael D, Hecker, Barry F
• Primary Examiner(s): Deak; Leslie R.
• Assistant Examiner(s): MARCETICH, ADAM M
• Application Number:
  US11/222,303
• Publication Number:
  US 20060196885A1
• Time in Patent Office: 1,790 Days
• Field of Search: 604/218, 604/289, 604/290, 604/310, 604/311, 222/129, 222/134, 222/142.2, 222/142.3, 222/142.6, 222/142.7, 222/142.9, 222/145.1, 222/144, 222/145.5, 222/145.6, 222/145.7, 222/145.8, 222/252, 210/198.1, 210/199, 210/205, 210/519, 210/542, 210/780, 210/787, 210/782, 210/790, 239/302, 239/310, 239/335, 239/398, 239/407, 239/413, 239/414, 239/419, 239/419.3, 239/569
• US Class Current: 604/540
• CPC Class Codes: A61M 1/02 Blood transfusion apparatus blood infusion by syringes A61M5/14
• CPC Class Codes: A61M 1/3693 using separation based on different densities of components, e.g. centrifuging
• CPC Class Codes: A61M 11/00 Sprayers or atomisers specially adapted for therapeutic purposes in general B05B; aerosol containers B65D83/14
• CPC Class Codes: A61M 11/06 of the injector type
• CPC Class Codes: B05B 11/028 Pistons separating the content remaining in the container from the atmospheric air to compensate underpressure inside the container
• CPC Class Codes: B05B 11/1011 without substantial movement of the nozzle in the direction of the pressure stroke
• CPC Class Codes: B05B 11/1084 each liquid or other fluent material being pumped by a separate pump
• CPC Class Codes: B65D 83/28 Nozzles, nozzle fittings or accessories specially adapted therefor
• CPC Class Codes: B65D 83/68 Dispensing two or more contents , e.g. sequential dispensing or simultaneous dispensing of two or more products without mixing them
• CPC Class Codes: B65D 83/682 the products being first separated, but finally mixed, e.g. in a dispensing head mixing in general B01F
• CPC Class Codes: B65D 83/685 with one product being located in a chamber within, or forming part of, the dispensing head, e.g. for admixture during dispensing

Abstract

A method and apparatus for separation, concentration, and/or applying a biological or bio-engineered fluid. Generally, the fluid application device includes a sprayer body to enable the application of the fluid and a container adaptable to enable the separation of the fluid into at least a first component and a second component. The container is releasably coupled to the nozzle. The nozzle is adapted to withdraw at least one of the first component or the second component from the container after the fluid has been separated to apply the fluid to a selected site.

Claims

1. A method of separating and applying at least one component of a multi-component fluid from a container, the method comprising:

disposing a multi-component fluid in the container;

forming a first fraction and a second fraction by centrifuging the multi-component fluid disposed in the container;

connecting the container to a spray assembly;

selecting at least a portion of the first fraction or the second fraction or both fractions with the spray assembly; and

withdrawing at least a portion of the first fraction or the second fraction or both fractions via the spray assembly, wherein the spray assembly is configured to withdraw both the first and second fractions while maintaining the connection of the container to the spray assembly;

wherein the first and second fractions are substantially vertically spaced apart from each other in the same container when selected.

2. The method of claim 1 further comprising:

spraying at least a portion of the first fraction or the second fraction into the atmosphere to mix with a second fluid.

3. The method of claim 2 further comprising:

spraying the second fluid onto the spray of either the first fraction or second fraction of the multi-component fluid; and

wherein the spray assembly sprays both the first fraction or second fraction and the second fluid.

4. A method of withdrawing a material directly from a patient and collecting a selected fraction of the material for later use, the method comprising:

filling a collection container with the material while the collection container is disposed in a sterile container;

forming at least a first fraction and at least a second fraction by centrifuging the material in the collection container;

removing the collection container from the sterile container;

connecting the collection container at a first end to a spray assembly, where a second end of the container includes a closed end;

selecting, with the spray assembly, only the first fraction or only the second fraction as a selected fraction; and

withdrawing at least a portion of the selected first or second fraction through only the first end of the container and through the spray assembly, wherein the spray assembly is configured to at least withdraw both the first and second fractions through only the first end of the container;

wherein the first and second fractions are substantially vertically spaced apart from each other in the same container when selected.

5. The method of claim 4 further comprising:

mixing in a vial a first reactant and a second reactant to form a second fluid while the spray assembly is within a sterile environment through a port in the sterile container; and

filling a reservoir disposed on the spray assembly with a second fluid, the reservoir coupled to the port in the sterile container.

6. The method of claim 5 further comprising:

dispensing at least a portion of the second fluid as the selected fraction is dispensed from the collection container to enable the second fluid to mix with the selected fraction external to the spray assembly.

7. The method of claim 5 further comprising:

opening the sterile container near a sterile field to allow access to the collection container from the sterile field.

8. The method of claim 5 further comprising:

passing the material through said sterile container of the collection container.

9. A method of separating and delivering at least one component of a multi-component material from a container, the method comprising:

placing a multi-component material in the container;

separating from the multi-component material, while the multi-component material is in the container, a first fraction having at least a first component of the multi- component material, and a second fraction having at least a second component of the multi-component material;

connecting the container at a first end to a withdrawal and delivery assembly;

selecting, through only the first end of the container, a selected fraction formed from at least a portion of the first fraction or a portion of the second fraction or a portion of both fractions via the withdrawal and delivery assembly; and

delivering the selected fraction through the first end of the container and through a spray nozzle of the withdrawal and delivery assembly, wherein the withdrawal and delivery assembly is configured to at least withdraw both the first and second fractions through only the first end of the container;

wherein the first and second fractions are substantially vertically spaced apart from each other in the same container when selected.

10. The method of claim 9, further comprising:

placing into the container a withdrawal tube that connects to the withdrawal and delivery assembly; and

actuating the withdrawal and delivery assembly to withdraw at least the portion of the first fraction or the second fraction.

11. The method of claim 10, wherein actuating the withdrawal and delivery assembly includes depressing a trigger piece.

12. The method of claim 9, wherein separating the first fraction and the second fraction includes centrifuging the container including the multi-component material.

13. The method of claim 12, wherein separating the first fraction and the second fraction further includes moving a buoy having a density that is less than that of the first fraction during centrifugation, where the buoy is buoyantly moved in a direction toward a top of the container.

14. The method of claim 12 further comprising:

spraying at least a portion of the first fraction or the second fraction into an atmosphere to mix with a second material.

15. The method of claim 14, wherein the spraying further comprises:

forming a generally conical mist with the withdrawal and delivery assembly while spraying either of the selected first fraction or second fraction;

forming droplets of the second material; and

enabling the formed droplets of the second material to enter the conical mist.

16. The method of claim 12 further comprising:

selecting both the first fraction and the second fraction with the withdrawal and delivery assembly;

spraying both the first fraction and the second fraction of the multi-component material into the atmosphere to mix; and

allowing the mixture of the first fraction and the second fraction to contact a region of a surface.

17. The method of claim 12, further comprising:

transferring a second material to the withdrawal and delivery assembly from a sterile container surrounding the withdrawal and delivery assembly;

placing the withdrawal and delivery assembly, including the second material from the sterile container, within a sterile field; and

delivering the selected fraction and the second material to a selected region.

18. The method of claim 12, wherein selecting the first fraction or selecting the second fraction includes selecting one of either a red blood cell fraction or a plasma fraction;

and

spraying one of the red blood cell fraction or the plasma fraction and a coagulant onto a surgical operation site prior to closing the incision.

19. A method of withdrawing a material directly from a patient and dispensing a material, the method comprising:

withdrawing the material from the patient;

placing the material into a collection container through a first end of the container while the collection container is positioned within a sterile container;

forming at least first and second fractions from the material in the collection container while the collection container is positioned within the sterile container;

removing the collection container from the sterile container;

connecting the collection container at only the first end to a spray assembly operable to select, through the first end of the container, one of the first and second fractions or both fractions as a selected fraction and dispense the selected fraction, wherein the spray assembly is configured to at least select both the first and second fractions through only the first end of the container;

filling a reservoir disposed on the spray assembly with a second fluid, the reservoir coupled to a port on the sterile container;

dispensing at least a portion of the second fluid as the selected fraction is dispensed through only the first end of the collection container and through the spray assembly to enable the second fluid to mix with the selected fraction outside the spray assembly;

wherein the first and second fractions are substantially vertically spaced apart from each other in the same container when selected.

20. The method of claim 19, further comprising:

actuating a trigger member of the spray assembly to dispense the selected fraction.

21. The method of claim 19, further comprising placing the collection container in the sterile container prior to withdrawing the material;

and wherein forming the selected fraction from the material includes positioning both the sterile container and the collection container in a centrifuge to separate the selected fraction from the material.