Pleural effusion treatment device, method and material

• US 7,766,938 B2
• Filed: 07/08/2005
• Issued: 08/03/2010
• Est. Priority Date: 07/08/2004
• Status: Expired due to Fees

• Current Assignee: Ekos LLC (Boston Scientific Corporation)
• Original Assignee: PneumRx, Inc. (Boston Scientific Corporation)
• Inventors: Wartchow, Charles, McGurk, Erin, Balceta, Jobert, Dieck, Ronald, Gong, Glen
• Primary Examiner(s): KAM, CHIH MIN
• Application Number:
  US11/177,926
• Publication Number:
  US 20060009801A1
• Time in Patent Office: 1,852 Days
• Field of Search: 606/214, 530/350
• US Class Current: 606/214
• CPC Class Codes: A61B 17/00491 Surgical glue applicators surgical adhesives A61L24/00; two-component delivery syringes A61M5/19
• CPC Class Codes: A61B 2017/00495 for two-component glue
• CPC Class Codes: A61M 2025/0073 Tip designed for influencing the flow or the flow velocity of the fluid, e.g. inserts for twisted or vortex flow
• CPC Class Codes: A61M 25/0041 pre-formed, e.g. specially adapted to fit with the anatomy of body channels urethral catheters A61F2/04
• CPC Class Codes: A61M 25/0068 Static characteristics of the catheter tip, e.g. shape, atraumatic tip, curved tip or tip structure
• CPC Class Codes: A61M 25/007 Side holes, e.g. their profiles or arrangements; Provisions to keep side holes unblocked
• CPC Class Codes: A61M 25/0074 Dynamic characteristics of the catheter tip, e.g. openable, closable, expandable or deformable
• CPC Class Codes: A61M 31/00 Devices for introducing or retaining media, e.g. remedies, in cavities of the body A61M25/00 takes precedence ; introducing or retaining ophthalmic products into the ocular cavities A61F9/0008

Abstract

The invention discloses a method of treating a patient for pleural effusion comprising percutaneously delivering an adhesive material to a pleural space of the patient. Suitable adhesive materials for performing any of the embodiments of the methods of the invention can be selected from the group consisting of hydrogels, collagen, poly(lactic acid), poly(glycolide), cyanoacrylates, glutaraldehyde, PEG, protein, and polysaccharide and derivatives thereof. The invention also discloses a pleural effusion treatment apparatus comprising an adhesive material adapted to adhere pleural membranes defining a pleural space and a pleural space access member adapted to deliver the adhesive material to the pleural space.

Claims

1. A method of treating a patient for pleural effusion, the method comprising:

percutaneously delivering an effective amount of an adhesive material to a pleural space of the patient by ejecting the adhesive material from a lumen of a percutaneous delivery device into the pleural space so as to cause a visceral pleura and a parietal pleura of the patient to adhere to one another such that excess fluid flow into the pleural space is inhibited; and

mixing components of the adhesive material in the delivery device prior to the ejecting step,

wherein the adhesive material has an adhesive strength up to 1.5 psi.

2. The method of claim 1 further comprising moving the delivery device from a delivery configuration to an operational configuration.

3. The method of claim 1 wherein the delivering step comprises delivering the adhesive material to the pleural space without delivering a fibrosis inducing material to the pleural space.

4. The method of claim 1 further comprising spreading the adhesive material within the pleural space.

5. The method of claim 1, wherein the adhesive material comprises a material selected from the group consisting of hydrogels, proteins, polymers and cross-linking agents.

6. The method of claim 5, wherein the hydrogel material comprises a material selected from the group consisting of hyalurons, hyaluronic acid, alginates, chitins, and chitosans.

7. The method of claim 5, wherein the protein material comprises a material selected from the group consisting of albumins, porcine albumin, collagens and gelatins.

8. The method of claim 5, wherein the polymer material comprises a material selected from the group consisting of poly(lactic acid) and poly(glycolide).

9. A method of treating a patient for pleural effusion, the method comprising:

percutaneously inserting a pleural space access member into the patient, wherein the pleural space access member comprises a suction device and a device for delivering an adhesive material; and

percutaneously delivering an effective amount of an adhesive material to a pleural space of the patient by ejecting the adhesive material from a lumen of a percutaneous delivery device into the pleural space so as to cause a visceral pleura and a parietal pleura of the patient to adhere to one another such that excess fluid flow into the pleural space is inhibited,

wherein the adhesive material has a viscosity level of 1.1 centipoise or higher.

10. The method of claim 9 further comprising applying suction to the pleural space prior to delivering the adhesive material to the pleural space.

11. The method of claim 10 wherein the applying step comprises applying suction through the pleural space access member and the delivering step comprises delivering the adhesive material through the pleural space access member.

12. A method of treating a patient for pleural effusion, the method comprising:

percutaneously delivering an effective amount of an adhesive material to a pleural space of the patient by ejecting the adhesive material from a lumen of a percutaneous delivery device into the pleural space so as to cause a visceral pleura and a parietal pleura of the patient to adhere to one another such that excess fluid flow into the pleural space is inhibited;

wherein the delivering step comprises delivering the adhesive material having an adhesive strength up to 1.5 psi.

13. A method of treating a patient for pleural effusion, the method comprising:

percutaneously delivering an effective amount of an adhesive material to a pleural space of the patient by ejecting the adhesive material from a lumen of a percutaneous delivery device into the pleural space so as to cause a visceral pleura and a parietal pleura of the patient to adhere to one another such that excess fluid flow into the pleural space is inhibited;

wherein the delivering step comprises delivering the adhesive material having an adhesive strength of between 0.2-0.6 psi.

14. A method of treating a patient for pleural effusion, the method comprising:

percutaneously delivering an effective amount of an adhesive material to a pleural space of the patient by ejecting the adhesive material from a lumen of a percutaneous delivery device into the pleural space so as to cause a visceral pleura and a parietal pleura of the patient to adhere to one another such that excess fluid flow into the pleural space is inhibited;

wherein the adhesive material having an adhesive strength up to 1.5 psi;

wherein the adhesive material comprises a material selected from the group consisting of hydrogels, proteins, polymers and cross-linking agents; and

wherein the cross-linking agent material comprises a material selected from the group consisting of glutaraldehyde and stable polyaldehyde.